Pharmacology II

Chapter 33

Drug Classes

• Antacids• H2 Receptor Antagonists• GI Prostaglandins• Proton Pump Inhibitors• Prokinetics Agents• Antispasmodic Agents

Antacids

• Aludrox• Baking soda• Di-Gel• Gelusil• Maalox• Mylanta• Phillips Milk of Magnesia• Rioopan• Titralac• Tums

H2 Receptor Antagonists

• Cimetidine Tagmet• Ranitidine Zantac• Nizatidine Axid• Famotidine Pepcid• Dizziness headache somnolence• Diarrhea constipation• SERIOUS: confusion, disorientation,

hallucination, gynecomastia Hepatoxicity!

GI Prostaglandins

• Misoprostol Cytotec• Diarrhea dose related after 2 wks. of therapy– Minimized by taking with meals, avoid Mg+

antacids, & @ bedtime• Pregnancy

Proton Pump Inhibitors

• Esomeprazole Nexium• Lansoprazole Prevacid• Omeprazole Prilosec• Pantoprazole Protonix• Rabeprazole Aciphex• Constipation dry mouth dizziness

Prokinetic Agents

• Metoclopramide Reglan• Drowsiness fatigue lethargy dizziness• SERIOUS: Extrapyramidal symptoms

Antispasmodic Agents• Atropine • Belldonna • Dicyclomine Bentyl• Glycopyrrolate Robinul• Mepenzolate Cantil• Methscopolamine Pamine• Propantheline Pro-Bathine• Scopolamine Scopace• Blurred vision constipation urinary retention dry mouth, nose, throat• SERIOUS: confusion, depression, nightmares, hallucinations• Orthostatic hypotension!!