Buscopan Tablets
Sirdalud (Tizanidine) is a muscle relaxant which helps to relax
certain muscles in your body. Sirdalud is available in tablets
containing 2 mg, 4 mg or 6 mg Tizanidine Hydrochloride.
It relieves the painful muscle spasms related to the static and
functional disorders of the spine or following certain surgeries
such as herniated intervertebral disc or osteoarthritis of the hip.
It is also used to treat spasticity due to neurological disorders
such as multiple sclerosis, chronic myelopathy, degenerative spinal
cord diseases, cerebrovascular accidents, and cerebral palsy.
Indications
Chemical Structure
The Recommended dosage of Sirdalud Tablets for various
indications is given below:Painful muscle spasms: 2 to 4 mg three
times daily.
Recommended Adult Dosage
Spasticity due to neurological disorders: The maximum initial
recommended dosage is 6 mg/day in 3 divided doses. The dosage is
then increased stepwise to achieve optimum therapeutic response
(generally between 12 to 24 mg/day). The maximum daily dose is 36
mg which should not be exceeded.
Recommended Adult Dosage
Missed Dose
If you miss a dose, take it as soon as you remember. However, if
you remember when it is almost time for your next dose, take only
your usual dose at that time.
Contraindications
Sirdalud Tablets are contraindicated in the following cases:
Known hypersensitivity to Tizanidine Hydrochloride or any
inactive ingredients of this medication.
Significantly impaired hepatic function.
Concomitant use with strong CYP1A2 inhibitors such as
fluvoxamine or ciprofloxacin.
Side Effects of Sirdalud Tablets
With low doses, such as those recommended for the relief of
painful muscle spasms the reported side effects were somnolence,
fatigue, asthenia, dizziness, dry mouth, nausea, gastrointestinal
disorder, transaminase increase, increased spasm or tone, blood
pressure decrease.
Side Effects of Sirdalud Tablets
With the higher doses, as recommended for the treatment of
spasticity, muscular weakness, insomnia, sleep disorder,
hallucination, hypotension, bradycardia, hepatitis and hepatic
failure have also been reported in addition to the side effects for
lower doses.
Warnings And Precautions
Co-administration of Sirdalud with inhibitors of CYP1A2 such as
some antiarrhythmics (amiodarone, mexiletine, propafenone),
cimetidine, some fluoroquinolones (enoxacin, pefloxacin,
norfloxacin), rofecoxib, oral contraceptives and ticlopidine is not
recommended.
Hypotension may occur with potential severe symptoms such as
loss of consciousness and circulatory collapse.
Gradual reduction in dosage is recommended to avoid withdrawal
syndrome.
Caution is advised in patients with impaired kidney
function.
Warnings And Precautions
Refrain from driving a vehicle or using machines if dizziness or
hypotension occurs.
Use during pregnancy only if benefit clearly outweighs the
risk.
Avoid breastfeeding.
Use in children not recommended and caution in elderly
patients.
Overdosage Symptoms
A decrease in sensorium was observed in the majority of cases
that included lethargy, somnolence, confusion and coma. Depressed
cardiac functions are also observed including most often
bradycardia and hypotension. Respiratory depression is another
common feature of tizanidine overdose.
Overdose Treatment
Should overdose occur, basic steps to ensure the adequacy of an
airway and the monitoring of cardiovascular and respiratory systems
should be undertaken. Symptoms should usually resolve within one to
three days following discontinuation of tizanidine and
administration of appropriate therapy.
Sirdalud Tablets 2 mg Manufactured by Novartis India
For more information click here
Sirdalud Tablets
The Swiss Pharmacy, Geneva Switzerland
