Masanao. Ichimata

Veterinary Endocrinology

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Background

1.

2.

3.

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Main Topics

1.

2. I. II.

3.

4.

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1.

T4 fT4 TSH

23

Euthyroid sick syndrome or Non-thyroidal illness syndrome

T4

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1. TSH

2. 1. 2.

Surks MI et al, New Engl J Med ,1995 Wenzel KW et al, Acta Med Austriaca, 1996

Economidou F et al, Hormones,2011 May not be copied or reprinted without Authors approval

3. T3T4 1. TBG

2. TBG

L-

3. NSAIDs

Surks MI et al, New Engl J Med ,1995 Wenzel KW et al, Acta Med Austriaca, 1996

Economidou F et al, Hormones,2011 May not be copied or reprinted without Authors approval

4. T3T4

1.

2. T4

Surks MI et al, New Engl J Med ,1995 Wenzel KW et al, Acta Med Austriaca, 1996

Economidou F et al, Hormones,2011

May not be copied or reprinted without Authors approval

5. T4

6.

Surks MI et al, New Engl J Med ,1995 Wenzel KW et al, Acta Med Austriaca, 1996

Economidou F et al, Hormones,2011

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2.

Wood MA et al, J Endocrinol. 2010 May not be copied or reprinted without Authors approval

ICU

1. T4 3.0843.05.0505.015

2. FT3ICUCRPNT-proBNP

Michael FS et al, JAMA, 1998

Wang F et al, Clin Care, 2012

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1. FT3 OR0.56 95%CI, 0.380.81 P

4. FT3 HR0.72 95%CI, 0.630.84 P

TSH

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Elliot DA et al, JVECC, 1995

TT3

49 vs. 75% Elliot DA et al, JVECC, 1995

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TT4TSH

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Elliot DA et al, JVECC, 1995

TT3TSH

vs. 100.3 81.0 vs 64.2 17.1 ng/dLP=0.01

TSH vs. 143.0 66.0 vs 96.6 38.3 ng/dLP=0.002

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Elliot DA et al, JVECC, 1995

1. 2. 3.

223 150

Kantrowitz LB et al, JAVMA, 2001

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fT4 T4

Kantrowitz LB et al, JAVMA, 2001 May not be copied or reprinted without Authors approval

TSH

Kantrowitz LB et al, JAVMA, 2001

T3

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TT3TT4fT4

1. TT47.628.459.7

2. fT47.616.843.5

TSH 10.66.38.1

Kantrowitz LB et al, JAVMA, 2001

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SIRS 189SIRS9

Wood MA et al, JVECC, 2014

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SIRS TT4 SIRS7/977.7 9/9100

P

SIRS FT4 SIRS4/944.4 1/911.1

P

SIRS TSH SIRSP

SIRS TT4fT4

1. T4TBG 2.

TBG 3.

Wood MA et al, JVECC, 2014

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Summary21

Wood MA et al, J Endocrinol. 2010 May not be copied or reprinted without Authors approval

Summary22 1.

2.

3.

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3.

Glanemann B et al, Tierrztl Prax 2008

24 4

1. 2. 3. 4.

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TT4 vs. p = 0.0002

26.17 8.24 vs. 18.84 9.62 nmol/L

4p=0.17 cTSH vs. p = 0.73

0.21 0.17 vs. 0.23 0.21 ng/ml

4p=0.43 Glanemann B et al, Tierrztl Prax, 2008

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Glanemann B et al, Tierrztl Prax, 2008 May not be copied or reprinted without Authors approval

Wood MA et al., JVIM, 2009

15

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T3

Wood MA et al, JVIM, 2009 May not be copied or reprinted without Authors approval

T4

Wood MA et al, JVIM, 2009

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fT4

Wood MA et al, JVIM, 2009

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TSH

Wood MA et al, JVIM, 2009

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T4 012

1. T4T4

12 1.

2.

Wood MA et al, JVIM, 2009 May not be copied or reprinted without Authors approval

FT4 12

1.

2. T4

3. 2 T4T3

Wood MA et al, JVIM, 2009 May not be copied or reprinted without Authors approval

FT4 12

4. fT4TBGT3

5. 6. CO2

Wood MA et al, JVIM, 2009 May not be copied or reprinted without Authors approval

Summary31

1. 12 T4 fT4 TSH

2. 1224 T4

Glanemann B et al, Tierrztl Prax, 2008 Wood MA et al, JVIM, 2009 May not be copied or reprinted without Authors approval

Summary32

3. 24 T4

Glanemann B et al, Tierrztl Prax, 2008 Wood MA et al, JVIM, 2009 May not be copied or reprinted without Authors approval

Summary33

1. 12 T4fT4TSH

2. 12 fT4T4 fT4 TSH

Wood MA et al, JVIM, 2009 May not be copied or reprinted without Authors approval

4.

T3LT3 LT3T3

ICUT3T4 TSHT3

Brent GA et al, J Clin Endocrinol Metab, 1986

Becker RA et al, Crit Care Med, 1982

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Brent GA et al, J Clin Endocrinol Metab, 1986

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Streptococcus peumoniae

FT4TT3

T4 T4

Little JS et al, Endocrinology, 1985

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Topliss Det al, Int J Endocrinol Metab, 2009

Warner MH et al, J Endocrinol , 2010 Economidou F et al, Hormones, 2011

Alan P al, Endocr Pract, 2008

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Conclusion

Euthyroid sick syndromeNon-thyroidal illness syndrome

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