S U B M I T T E D T O - P R E S E N T E D B Y-

M R S . J Y O T H I Y. B H AV YA R E WA R I

A S S T. P R O F F. , M . P H A R M , I S T Y E A R

D E PA RT M E N T O F P H A R M A C O L O G Y

K R U PA N I D H I C O L L E G E O F P H A R M A C Y, B A N G A L O R E

Translational

Pharmacology1

Contents

2

Introduction

Need of Translational Pharmacology

Objectives

Importance of Translational Pharmacology

Hurdles in Translational Pharmacology

Reference

Introduction

Translational pharmacology is the application ofbiomedical research, conducted to support drugdevelopment, which aids in patient selection, dosingregimen and segmentation of diseases

It is the concept of translating the laboratoryfindings into the clinic i.e. patient care, for achievingbetter patient treatment

This concept is called as ‘ Bench to Bedside’

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It may involve the process of molecular research ofdrug in laboratory to clinical care

This is often termed as ‘molecular medicine’ or‘personalized medicine’

It encompasses the following-

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The definition of guidelines of drug development orfor the identification and validation of clinicallyrelevant biomarkers

Experimental, non-human or non-clinical conductedto develop principles for the discovery of newtherapeutic strategies

Clinical investigations that provide a biologicalfoundation for the development of improvedtherapies

Basic science studies that define the biological effectof therapeutics in humans

Need of Translational Pharmacology

6

Pharmacology as a discipline, spans from molecularstudies to investigations in animal models andhuman clinical trials

With increase in specialization in all branches ofbiological and clinical sciences, there is an increasedneed to bridge the sciences through translationalpharmacology

Advanced technologies such as genomics,proteonomics, bioinformatics etc are powerful toolsfor translational research

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Preclinical work may be significantly dissimilar tothat in human models and results may not beextrapolated

Therefore, Translational Pharmacology is the termwhich appropriately describes the successfulintegration of scientific discoveries with theirapplications in treatment of human beings

Objectives

8

To discover the origin, pathway and mechanism ofdiseases including the responsible biomarkers

To systematically discover and develop newdiagnostics and therapeutic methods

To discover drugs in short duration of time

Importance of Translational

Pharmacology

9

Translational Pharmacology can answer to some simple questions, once a drug has emerged from a screening cascade

By testing an agent in a number of models of human diseases, one can achieve better pre-clinical results

Dosing schedules can be tested in the clinic for maximum therapeutic benefits with minimum toxicity, based on the profile of the molecule and data from the clinical models

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Proof of mechanism

Proof of concept

Proof of principle/ biology

Actual benefits of the concerned molecule

Bench side studies

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These include-

i. In silico

ii. In vitro

iii. In vivo

In silico

12

These methods include developing and validating complex mathematical models capable of representing human disease and response to the therapeutic interventions

Not this alone, it also includes the computational forms screening i.e. virtual screening

Results obtained in the clinical settings can then be refactored into integrated mathematical models to enhance their translational potential

Hurdles in Translational

Pharmacology

13

Scientific hurdles

Ethical hurdles

Regulatory hurdles

Inadequate financial support

Shortage of investigators

Reference

14

Maiti Rituparna,” Postgraduate Topics in Pharmacology”, page number-249-256, 1st edition, Paras Medical Books.