WCA 2016 - Abstract SubmissionTopic: Obstetric

WCA16-ABS-1514VARIABILITY OF ENTROPY AS AN INDICATOR FOR STABILITY OF ANAESTHESIA DEPTHDURING IN VITRO FERTILIZATION PROCEDURES

Vera Potievskaya * 1, Igor Ushakov2

1Anaesthesiology and Intensive Care, Russian Medical Academy for Postgraduate Training, 2Anaesthesiology , Clinicalhospital Moskvorechye, Moscow, Russian Federation

Preferred presentation method: e-Poster or oral communicationI confirm that I fulfill eligibility criteria and that I wish to apply for a travel bursary: NoDo yo wish to submit a case study or research abstract?: Research abstractBackground & Objectives: It has been shown that entropy monitoring allows to assess depth of anaesthesia andimproves anaesthesia awareness [1, 2]. Usually response entropy (RE) and state entropy (SE) are measured. Wesuggested a new calculated parameter - variability of entropy (VE) to evaluate stability of anaesthesia. The objective ofthe study was to compare stability of intravenous propofol and volatile sevoflurane anaesthesia during oocytes retrievalby VE assessment.Materials & Methods: 26 women of ASA physical status I scheduled for oocytes retrieval were randomized into twogroups. Induction of anaesthesia was performed with sevoflurane (group 1) or intravenous intermittent propofol boluses(group 2). RE and SE were recorded, VE was calculated as RE-SE/SE×100%. We compared results in the two groupsduring periods of induction, time of oocyte retrieval (intervention) and awake. Data were presented as median [25%; 75%interquartile ranges], Mann-Whitney test was applied.Results: In all patients RE and SE values decreased during all periods that reflected adequate depth of anaesthesia anddid not significantly differ between groups. VE was higher in the group of propofol comparing with sevoflurane duringperiods of oocyte retrieval (p<0.05), but there was no significant difference in the period of induction and awakeningperiod between two groups (table). This fact may reflect analgesics effect of sevoflurane because of lower RE values.

Table.Variability of entropy during sevoflurane and propofol anaesthesia.

Variables Sevoflurane Propofol PVE baseline, % 10,1[10; 12,9] 10,1 [8,8; 11,4] 0,89VE induction, % 5,2 [1,2; 21,4] 39,1 [6,2; 26,4] 0,34VE intervention, % 0 [0; 4,8] 16,6 [0; 20] 0,02VE awake, % 10,5 [8,7; 15,1] 10,5 [9,2; 12,6] 0,98

 Conclusion: Assessment of variability of entropy in addition to RE and SE allows not only detect the depth ofanaesthesia, but also more clearly evaluate its stability and balance of hypnotic and analgesic effects. Use of volatileanaesthetic sevoflurane during oocytes retrieval demonstrated more stable anaesthesia level than propofol. References: 1. Bein B. "Entropy". Best practice&research clinical anesthesiology 2006, 20 (1): 101-109. 2. Gao JD, ZhaoYJ, Xu CS, Zhao J et al. "Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: amulticenter clinical trial". Chin Med J (Engl), 2012, 125 (8): 1389–92.

Disclosure of Interest: None declared