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Your Personal Microbial GardenBalancing your Immune System
Your Autoimmunity ConnectionSecond Annual Targeting the Microbiome September 20-21, 2016 Bonnie Feldman DDS, MBA @DrBonnie360
Your Personal Microbial Garden
[email protected]@DrBonnie360 www.facebook.com/YourAutoimmunityConnection
Bonnie Feldman, DDS, MBADrBonnie360’s mission is to create a digitally connected world of personalized care for autoimmune patients.
We consult with start-up companies and entrepreneurs who are bringing new products and services that will improve research, diagnosis, and treatment for autoimmunity Content and Visual Design – Tiffany Simms
“I may be small and unknown today, but I have big ambitions for tomorrow”
– Author Unknown
• Barin, Jobert, Lawrence Tobias, and Daniel Peterson. “The Microbiome and Autoimmune Disease: Report from a Noel R. Rose Colloquium.” Clinical Immunology 159, no. 2 (2015): 183–188. doi:10.1016/j.clim.2015.05.009 <http://www.ncbi.nlm.nih.gov/pubmed/26003843>
• Bitar, Khalil, and Elie Zakhem. “Bioengineering the Gut: Future Prospects of Regenerative Medicine.” Nature Reviews Gastroenterology & Hepatology (2016). doi:10.1038/nrgastro.2016.124<http://www.ncbi.nlm.nih.gov/pubmed/27507104>
• Cusick, Matthew, Jane Libbey, and Robert Fujinami. “Molecular Mimicry as a Mechanism of Autoimmune Disease.” Clinical Reviews in Allergy & Immunology 42, no. 1 (2012): 102–111. doi:10.1007/s12016-011-8294-7.<http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266166/>
• Fasano, Alessio. “Leaky Gut and Autoimmune Diseases.” Clinical Reviews in Allergy & Immunology 42.1 (2012) : 71–8. <http://www.ncbi.nlm.nih.gov/pubmed/22109896>
Autoimmunity and the Microbiome
• Gomez, Andres, David Luckey, and Veena Taneja. “The Gut Microbiome in Autoimmunity: Sex Matters.”Clinical Immunology 159.2 (2015) : 154–162. <http://www.sciencedirect.com/science/article/pii/S1521661615001576>.
• Kamdar, K et al. “Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.” Cell Host & Micobe 19.1 (2016) : 21-31. <http://www.cell.com/cell-host-microbe/pdfExtended/S1931-3128(15)00498-9>.
• McLean, Mairi et al. “Does the Microbiota Play a Role in the Pathogenesis of Autoimmune Diseases?” Gut 64.2 (2014) : gutjnl–2014–308514. <http://gut.bmj.com/content/early/2014/11/28/gutjnl-2014-308514>.
• Opdenakker, Ghislain, Paul Proost, and Jo Damme. “Microbiomic and Posttranslational Modifications as Preludes to Autoimmune Diseases.”Trends in Molecular Medicine (2016). doi:10.1016/j.molmed.2016.07.002. <http://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(16)30077-6?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471491416300776%3Fshowall%3Dtrue>
Autoimmunity and the Microbiome
• Tamburini, Sabrina, Nan Shen, Han Wu, and Jose Clemente. “The Microbiome in Early Life: Implications for Health Outcomes.” Nature Medicine 22, no. 7 (2016): 713–722. doi:10.1038/nm.4142. <http://www.ncbi.nlm.nih.gov/pubmed/27387886>
• Waldor, Matthew et al. “Where next for Microbiome Research?” PLoS Biology 13.1 (2015) : e1002050. <http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002050>.
• Wu, Hao, Valentina Tremaroli, and Fredrik Bäckhed. “Linking Microbiota to Human Diseases: A Systems Biology Perspective.” Trends in Endocrinology & Metabolism 26.12 (2015) : 758-770. <http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00194-0>.
• Rao, Meenakshi, and Michael Gershon. “The Bowel and beyond: The Enteric Nervous System in Neurological Disorders.” Nature Reviews Gastroenterology & Hepatology (2016). doi:10.1038/nrgastro.2016.107. <http://www.nature.com/nrgastro/journal/vaop/ncurrent/full/nrgastro.2016.107.html>
Autoimmunity and the Microbiome
The Gut is Where it’s At – Brain-Gut Axis
A Life Balance – Inflammatory Bowel Disease• DeFilippis, Ersilia, Robbyn Sockolow, and Elaine Barfield. “Health Care Maintenance for the
Pediatric Patient With Inflammatory Bowel Disease.” Pediatrics (2016). doi:10.1542/peds.2015-1971.<http://pediatrics.aappublications.org/content/early/2016/08/01/peds.2015-1971>
• De Souza, Heitor, and Claudio Fiocchi. “Immunopathogenesis of IBD: Current State of the Art.” Nature Reviews Gastroenterology & Hepatology (2015) : 13-27 <http://www.ncbi.nlm.nih.gov/pubmed/26627550>.
• Sartor, R. Balfour. “The Intestinal Microbiota in Inflammatory Bowel Disease.” Nestle Nutrition Institute Workshop Series 79 (2014) : 29–39.<https://uncch.pure.elsevier.com/en/publications/the-intestinal-microbiota-in-inflammatory-bowel-diseases>.
• Sartor, RB, and SK Mazmanian. “Intestinal Microbes in Inflammatory Bowel Diseases.” The
American Journal of Gastroenterology … (2012) : 15-21. <http://www.nature.com/ajgsup/journal/v1/n1/abs/ajgsup20124a.html>.
A Life Balance – Celiac Disease• Cenit, María, Marta Olivares, Pilar Codoñer-Franch, and Yolanda Sanz. “Intestinal
Microbiota and Celiac Disease: Cause, Consequence or Co-Evolution?” Nutrients 7, no. 8 (2015): 6900–6923. doi:10.3390/nu7085314. <http://www.mdpi.com/2072-6643/7/8/5314/htm>
• Leonard, Maureen M, Stephanie Camhi, Tania B Huedo-Medina, and Alessio Fasano. “Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Study Design: Approach to the Future of Personalized Prevention of Celiac Disease.” Nutrients 7, no. 11 (November 2015): 9325–36. doi:10.3390/nu7115470.<http://www.mdpi.com/2072-6643/7/11/5470/htm>
• Wlodarska, Marta, Aleksandar Kostic, and Ramnik Xavier. “An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases.” Cell Host & Microbe 17.5 (2015) : 577-591. <http://www.cell.com/cell-host-microbe/abstract/S1931-3128(15)00166-3>.
• Glenn, Justin, and Ellen Mowry. “Emerging Concepts on the Gut Microbiome and Multiple Sclerosis.”Journal of Interferon & Cytokine Research : The Official Journal of the International Society for Interferon and Cytokine Research 36, no. 6 (2016): 347–357. doi:10.1089/jir.2015.0177.http://www.ncbi.nlm.nih.gov/pubmed/27145057
• Jangi, Sushrut, Roopali Gandhi, Laura Cox, Ning Li, Felipe von Glehn, Raymond Yan, Bonny Patel, et al. “Alterations of the Human Gut Microbiome in Multiple Sclerosis.” Nature Communications 7 (2016): 12015. doi:10.1038/ncomms12015.http://www.nature.com/ncomms/2016/160628/ncomms12015/full/ncomms12015.html
Beyond the Gut – Multiple Sclerosis
• Costalonga, M, and MC Herzberg. “The Oral Microbiome and the Immunobiology of Periodontal Disease and Caries.” Immunology Letters 162.2 (2014) : 22-38. <http://www.sciencedirect.com/science/article/pii/S0165247814001874>.
Rheumatoid Arthritis
Systemic Lupus Erythematosus
• Terato, Kuniaki, Christopher T Do, and Hiroshi Shionoya. “Slipping through the Cracks: Linking Low Immune Function and Intestinal Bacterial Imbalance to the Etiology of Rheumatoid Arthritis.”Autoimmune Diseases 2015 (January 04, 2015): 636207. doi:10.1155/2015/636207.http://www.hindawi.com/journals/ad/2015/636207/
• Scher, JU, and SB Abramson. “The Microbiome and Rheumatoid Arthritis.” Nature Reviews Rheumatology 7 (2011) : 569-578. <http://www.nature.com/nrrheum/journal/v7/n10/abs/nrrheum.2011.121.html>.
• Mu, Q, H Zhang, and XM Luo. “SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?” Frontiers in Immunology (2015) : n. pag. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663251/>.
Beyond the Gut
Tailor-Made – Personalizing Nutrition• Biesalski, Hans. “Nutrition Meets the Microbiome: Micronutrients and the Microbiota.”
Annals of the New York Academy of Sciences 1372, no. 1 (2016): 53–64. doi:10.1111/nyas.13145.http://www.ncbi.nlm.nih.gov/pubmed/27362360
• Moelling, Karin. “Nutrition and the Microbiome.” Annals of the New York Academy of Sciences 1372, no. 1 (2016): 3–8. doi:10.1111/nyas.13039. http://onlinelibrary.wiley.com/doi/10.1111/nyas.13039/abstract
• Tilg, H, and AR Moschen. “Food, Immunity, and the Microbiome.” Gastroenterology 148.6 (2015) : 1107-1119. <http://www.sciencedirect.com/science/article/pii/S0016508515000128>.
• Wasielewski, Helen, Joe Alcock, and Athena Aktipis. “Resource Conflict and Cooperation between Human Host and Gut Microbiota: Implications for Nutrition and Health.” Annals of the New York Academy of Sciences 1372, no. 1 (May 2016): 20–8. doi:10.1111/nyas.13118http://onlinelibrary.wiley.com/doi/10.1111/nyas.13118/full
• Zeevi et al. “Personalized Nutrition by Prediction of Glycemic Responses.” Cell. 163.5 (2015) : 1079-1094. <http://www.cell.com/abstract/S0092-8674(15)01481-6>.
• Zmora, N et al. “Taking It Personally: Personalized Utilization of the Human Microbiome in Health and Disease.” Cell Host & Microbe 19.1 (2016) : 12-20. <http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)00508-9.pdf>.
Prebiotics & Probiotics• Hemarajata, P, and J Versalovic. “Effects of Probiotics on Gut Microbiota: Mechanisms of
Intestinal Immunomodulation and Neuromodulation.” Therapeutic Advances in Gastroenterology. (2012) : 39-51. <http://tag.sagepub.com/content/early/2012/09/24/1756283X12459294.abstract>.
• Petschow, B et al. “Probiotics, Prebiotics, and the Host Microbiome: The Science of Translation.” Annals of the New York Academy of Sciences (2013) : 1-17. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.12303/full>.
Tailor-Made – Personalizing Nutrition
• Autoimmune Disease: An Invisible Epidemic http://bit.ly/1m0ttsl• The Serious Health Concern All 20-somethings Should Know About
http://bit.ly/R9cEgp • Decoding Autoimmunity – a Summary of the State of the Art http://bit.ly/1knzaAQ • The Lonely Voices of Autoimmune Disease via Youtube http://bit.ly/X41mMv• Believe It or Not – The Real Voices of Autoimmunity http://bit.ly/20xRCXO
Your Autoimmunity Exploration
