Disease State Plasma

“We identify rare materials for early disease or esoteric

markers through our extensive screening

programme”

Save time & optimise your success rate - highly characterised disease state plasma units. Large inventory stored at our facilities

Confidence in supply - collecting directly from hospitals and blood banks

Quality/traceability - materials collected

with ethics approval and/or donor consent when relevant, storage at a HTA licenced facility

Global operations - Facilities in the UK and Containment Level 3 laboratories in South Africa to process infectious disease state plasma

Disease state plasma and clinical specimens

Local sourcing in three continents

Partnerships with local

blood banks and

hospitals

Shipping hubs in three

continents

Ethical & regulatory

compliance

CL2 laboratory Non-infectious DSP

collection at source Screening Processing Testing

CL3 laboratory Infectious DSP

collection at source Can be collected

liquid 2-8C Screening / viral

load testing / genotyping

Processing Testing

Kent, UK

Cape Town, South Africa

Suggested disease phase *Number of Units

characterised in 20131) HBV, Early Acute Phase 62) HBV, Acute Phase (Infectious & Carrier), HBcAb 33) HBV, Early Acute Phase (infectious), HBeAg 24)N HBV, Acute Phase (Infectious & Carrier), HBeAg & HBcAb 25) HBV, Acute Phase (Carrier), HBc IgM 36) HBV, Late Acute Phase 101

Hepatitis B screening program

* Suggestions based on biomarker results interpretation, not actual diagnosis

Hepatitis B screening

programme

HCV / HIV Recovered

Plasma

Syphilis Recovered

Plasma

Specialty infectious disease state plasma

• Units of 250ml• Semi-quantitative

immunological data• Viral load &

genotyping data• Donor consent

• Units of 250ml +• Large range of titres• Donor consent• Measured MHA-TP

ratio from 1:4 through to 1:256

• Rare early acute phase• Screened for numerous

analytes:

HbSAg Hep B Core IgM Ab Hep B Core Total Ab Hep B e Ag Hep B e Ab

On-going autoimmune disease state plasma screening programme Regular supply - screening programme

to characterise over 40L of autoimmune disease state plasma every month

High quality products - collect under ethics approval, and carry out viral testing

The best results - test for numerous markers and provide extensive characterisation data

Customisation for bulk - pool process units and QC to meet defined specifications

Current Inventory:

A-GBM

ANCA (Anti-PR3 / Anti-MPO)

A-RNP / A-SS-A

SAA / CRP

RF

Celiac Disease

Crohn’s Disease

A-Tg

A-TPO

Infectious Disease Autoimmune Cardiac Chlamydia IgG / IgM

Anti-GBM Anti-RNP / Anti-SSA

Cholesterol

CMV IgG / IgM / Negative ANCA (Anti-MPO / Anti-PR3) HDL EBV IgG / IgM Celiac Disease Hypertension H. Pylori Crohn’s Disease LDL HAV IgG / IgM Gliadin Antibodies IgA / IgG Triglyceride HCV IgG HAMA HBsAg Rheumatoid Factor Organ Failure / Impairment HBc IgM / Total Ab SLE Renal Failure HBeAg / HBeAb Tissue Transglutaminase Abs Kidney Transplant HIV 1 Liver Transplant HIV 2 Autoimmune Thyroid Disease HIV O Anti-Tg Drugs of Abuse HSV 2 IgG / IgM Anti-TPO CDT HTLV-1 Graves Disease HTLV-2 Hashimoto’s Disease Pregnancy HEV Amniotic Fluid Lyme IgG / IgM Diabetes Pregnancy Serum Malaria Glucose Chronological Bulk Urine Parvovirus B19 HbA1c Rubella IgG / Negative Diagnosis (Type I / II) Syphilis IgG / IgM Other Biomaterials Toxoplasma IgG / IgM / Negative Inflammation / Allergy CSF

CRP UrineBiochemistry SAA Saliva Vitamin D Specific IgE (Allergy) Cord Serum

Our capabilities | Disease State Plasma

Infectious disease clinical sample panels

Our clinical sample panels are readily available - saving you time when validating your assay

Specifications

Citrated plasma Extensive donor demographics Tested for HIV1 & 2 Abs, HBsAg, HCV

Ab, HIV-1/HBV/HCV PCR and Syphilis Individual donors (no duplicates) Donor consent

HIV Positive Panel

+ Genotypes B, C, D, F, K+ Testing results for multiple markers+ Quantitative viral load result

HBsAg Positive Panel

+ Rare combination of HBV markers, including early stages+ Testing results for multiple markers

Our capabilities | Clinical SamplesInfectious Disease Autoimmune Cardiac Chlamydia pneumoniae IgA/IgG ASO Cholesterol Chlamydia trachomatis IgA/IgG Anti-Cardiolipin CK-MB CMV IgG / IgM / Negative Anti-CCP D Dimer EBV Anti-dsDNA HDL HCV IgG Anti-GBM Hypertension HBsAg / Anti-HBs Anti-Nuclear Antibodies (Includes: LDL HBc IgM / Total Ab SS-A/Ro, SS-B/La, Sm, RNP, Scl-70, Myoglobin HBeAg / HBeAb Jo-1, PM-SCL, KU, Centromere, NT proBNP HEV AMA-M2, RIB-P, RO52) – NEW Triglyceride HIV 1 Anti-Tg Troponin I HIV 2 Anti-TPO HIV O ANCA (Anti-MPO / Anti-PR3) Neurological HTLV-1 Celiac Disease Alzheimer’s Disease HTLV-2 Crohn’s Disease NSE Malaria Gliadin Antibodies IgA / IgG Measles IgG HAMA Diabetes Mycoplasma pneumoniae Histone Antibodies HbA1c Parvovirus B19 Rheumatoid Factor Diagnosis (Type I / II) Rubella IgM / IgG / Negative SLE Sepsis Tissue Transglutaminase Abs Organ Failure/Impairment Syphilis IgG / IgM Renal Failure Toxoplasma IgG / IgM / Negative Oncology Hepatic Impairment Yersinia IgG / IgM AFP

CA 125 EndocrinePregnancy CA 15-3 Cortisol hCG CA 19-9 FSH Pre-eclampsia CEA LH Pregnancy serum (1st/2nd/3rd trimesters) CYFRA Oestradiol

PSA ProgesteroneBiochemistry Prolactin Vitamin D Thyroid SHBG Bilirubin (Total) Free T3 (Triiodothyronine) Testosterone Calcium Free T4 (Thyroxine) Potassium Parathyroid Hormone (PTH) Drugs of Abuse CRP TSH Urine

CDTAllergy Raised Specific IgE

Custom Plasma collection – Custom anticoagulant, capabilities of >500L per month

“Packed” red cells available in bulk

Access to various normal patient samples demographics to allow representative testing cohorts

Custom control of the pre-analytical phase available

“Looking for something specific? We offer custom collections to meet your

inclusion/exclusion criteria”

Our capabilities | Normal Blood Products