Jayakar Johnson Joseph

FROM THE CAUSALITY OF NUCLEAR TRANSMUTATION TO

GENOMIC MUTATION

INTRODUCTION

Debating:

Chronic intrinsic radiation from in-vivo radioactive decay is mutagenic, and not the direct effect of acute external radiation.

In comparison with other industrial applications, radiation hazards from Healthcare, is negligible and easily manageable with safety standards

MUTAGENESIS

Nuclear Transmutation

Chronic Intrinsic Ionizing Radiation

Food web & Food chain

Radiation from Industry

Point mutations

Large-scale mutations

CarcinogenicOncogenicMetabolicUsefulRepairable

MANIFESTATION

Evolution TumorsMetabolic disorders

Manifestation Hierarchy

Nuclear transmutation

Conversion of one chemical element or isotope into

another

eg. Potassium-40 Argon-40

Caused by:

1. Nuclear reaction: Chain reaction

External particle reacts with a nucleus

2. Radioactive decay

No external particle needed to trigger... ??

Food Chain from Food Web

Radioactive Isotope reaches Humans through Food chain

Ionizing Radiation from Radioactive decay

An ion is an atom or molecule in which the

total number of electrons is not equal to the

total number of protons, giving it a net positive

or negative electrical charge.

Ionization is the process of converting an atom or molecule into an ion by adding or removing

charged particles such as electrons or other ions.

Mutagenesis

Mutations are changes in a genomic sequence: the DNA molecular sequence

Viral

Cytosine, Guanine, Adenine,

Thymine, Uracil MUTATION PHENOMENA

Modification of bases

Spontaneous hydrolysis

Cross linking

Dimerization

Intercalation between bases

MolecularIonic variability

Backbone damage

AtomicIonic variability

ChronicIntrinsic Ionizing

radiation

Insertional mutagenesis

Pathological Manifestations of Mutations

Change in Cellular Physiology

Change in Cellular Architecture

Change in Apoptosis

Metabolicdisorders

Oncological disorders

Carcinogenesis

Excluding phenotypic manifestations

If chronic intrinsic ionizing

radiation persists

Conclusions:

Supportive reference

In biological systems, Chronic intrinsic ionizing radiation is

mutagenic that is not the direct effect of acute external radiation.

1. All isotopes of an element have same in-vivo biochemical activity, whereas

there biophysical activity differs.

2. Autofluorescent cell organelles:

• Mitochondria

• Lysosome

3. Photosynthesis

Is Fusion and Fission are spontaneous

and interrelated phenomenon … ??

Thank you

Q & A