* GB786134 (A)

Description: GB786134 (A) ? 1957-11-13

Improvements relating to clothes driers

Description of GB786134 (A)

PATENT SPECIFICATION 7869134 Date of Application and filing Complete Specification: Jan 10, 1956. of 078 j/ Application made in United States of America on Jan 14, 1955. Complete Specification Published: Nov 13, 1957. Index at acceptance:-Class 34 ( 2), Q( 1 K:2 C 11 B). International Classification:-F 26 b. COMPLETE SPECIFICATION Improvements relating to Clothes Driers We, HOOVER LIMITED, a Company registered under the Laws of Great Britain, of Perivale, Greenford, Middlesex, do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement:- This invention relates to driers According to the present invention a tumbler drier for clothes comprising a drum mounted to rotate about a horizontal axis within an outer casing is characterised by a turbine arranged within the casing to receive a flow of air under pressure from a remote source, for instance, a suction cleaner, and operatively connected to the drum to rotate it Preferably the air after passing the turbine blades passes through the drum In one arrangement the turbine blades are mounted on the drum, in which case the blades are preferably mounted on one end wall of the drum and an annular air passage is included, one end of which is connected to a pipe connection on the outer casing, and the other end of which lies adjacent the turbine blades. In an alternative arrangement the turbine is operatively connected to the drum through a reduction drive The reduction drive may include one or more pairs of friction pulleys.

The invention may be carried into practice in a number of ways but two specific embodiments will now be described by way of example with reference to the accompanying drawings in which: Fig 1 is a sectional side elevation of a drier incorporating the present invention, Fig 2 is a sectional end elevation on the line 2-2 of Fig 1; Fig 3 is a part S 6 ctional end elevation on the line 3-3 of Fig 1; Fig 4 is a sectional side elevation of a modified form of the invention, and Fig 5 is a sectional view of a detail of a turbine of the drier of Fig 4. lPrice In the embodiment shown in Figs I to 3 the drier comprises a sheet metal casing 10 formed in lower and upper sections 11 and 12, of which the latter forms a cover for the drier and rests on an inwardly offset edge 50 13 of the rim of the lower section 11 A pair of handles 14 secured at opposite ends of the upper section 12 enable the complete drier to be carried with ease As shown in Fig 3 the lower section 11 of the casing 55 carries toggle latches 15 which engage integral hooks 16 on the upper section 12 in order to hold it down. In one wall of the casing, on the right as viewed in Fig 1, herein referred to for con 60 venience as the front wall, is a centrally disposed air inlet 17 within which is situated a short tubular conduit 18 which in turn is provided with an annular latch engaging lip 19 The end of a cleaning tool hose 20 can 65 be fitted into the conduit 18 and retained by means of diametrically opposite spring latches 21 engaging the lip 19 In this way a suction cleaner, for instance, of the canister type, can be connected to the drier to pro 70 vide a source of air under pressure The opposite or rear wall of the lower section 11 of the casing is provided with an air outlet 22 affording diffuser louvres. Secured to the lower wall of the lower cas 75 ing 11 by means of rivets 26 is a U-shaped frame 25 having upstanding rear and front legs 27 and 29 respectively carrying ball bearings 28 and 30 for a rotary drying drum or cage 31 The drum has a circular front 80 end 32 from which are punched out a number of large area turbine blades 33 leaving openings 24 for the passage of air The end 32 has a central recess 34 in which is welded a nut 35 into which is screwed a stub shaft 85 36 carried by the ball bearing 30, to support this end of the drum. The drum also has a circular rear end 37 having a stub shaft 38 secured to its centre by a nut 39 and carried by the ball bearing 90 No 890/56. 786,134 28 to support this end of the drum The rear end 37 of the drum has in it a number of openings 40 for the passage of air. The ends 32 and 37 of the drum are joined by a cylindrical wall 41 of rigid wire mesh having sufficient strength to support a load of wet clothes when placed within the drum. At one point an oblong portion of the wire mesh is cut away to afford

an opening by which access may be had to the drum for filling and emptying This opening is bounded by a flanged rim 42 and closed by a door 43 having a flanged frame 44 to which is secured wire mesh material of the same character as that forming the cylindrical wall 41 In this way the whole of the drum forms a unitary wire cage The door 43 is provided with hinges 45 secured to the rim 42 of the opening in the drum 31 As shown in Fig 3 on the opposite side from the hinges the door is provided with a sliding latch 46 engaging a hook 47 integrally formed on the rim 42 of the opening in the drum In this way the latch 46 secures the door 43 in the closed position and the drum can accordingly be rotated without any danger of wet articles falling out of it At its forward end immediately behind the turbine blades 33 the drum is provided with a frame 48 having a transverse wire mesh endwall 49 mounted on it to prevent clothes obstructing the turbine blades 33. Between the turbine blades 33 and the front wall of the outer casing 10 a flaring annular air passage 50 is afforded by conical outer and inner walls 51 and 54 The smaller end of the conical outer wall 51 surrounds the short air inlet conduit 18 while its larger end terminates in a vertical wall 52 secured by a screw 53 to the front upstanding leg 29 of the U-shaped frame 25 The inner conical wall 54 is also secured to the upstanding leg 29, by means of a screw 55. Thus it will be seen that the annular air passage 50 opens opposite the turbine blades 33 in the front end wall 32 of the drum 31. In this way air blown into the drier through the pipe 20 is directed on to the turbine blades 33. It is believed that the operation of this embodiment will be apparent from the drawings and foregoing description A load of damp clothes is placed in the wire drum 31 by removing the upper section 12 of the outer casing and opening the door 43 of the drum. After the clothes are inserted the door is closed and the upper section of the casing replaced An outside source of air under pressure, such as a suction cleaner, is then connected to the inlet conduit 18 whereupon the air will be directed by means of the annular passage 50 on to the turbine blades 33, causing the drum to rotate and tumble the clothes After passing through the turbine blades the air is directed through the clothes within the drum and out through the outlet louvres 22 at the rear end of the outer casing. The air from a suction cleaner is often warm due to cooling of the suction cleaner motor, and in this case the drying of the clothes will 70 be assisted. A second embodiment of the invention is shown in Figs 4 and 5 Certain parts of this embodiment are identical with corresponding parts in the embodiment of Figs l to 3 and 75 these parts bear the same reference numerals.

In this arrangement the tumbler drum 31 is similar in many respects to that of the first embodiment but the front end of the wire cage is gripped between a pair of flanged 80 rings 65, whilst its front wall 66 comprises a disc of wire mesh material the periphery of which is also gripped between the flanged rings 65 The centre of the front wall 66 is provided with a socket 67 within which a 85 bearing 68 is mounted to receive one end of a short shaft 69 to rotatably support the drum The other end of the shaft has a reduced diameter portion 70 which is received ip an upstanding post 71 to which it is 90 secured by a nut 72 A lock-waslher 73 prevents the shaft 69 from rotating A ball thrust bearing 74 is press fitted to the shaft 69 with its outer race press fitted within a cup 74 ' secured adjacent the inner side of the 95 post 71 The ball thrust bearing 74 supports the thrust of a collar 75 mounted on the shaft around a bearing 76 The collar 75 is rotatable on the shaft 69 and has a sheet metal turbine 77 secured to it The turbine has 100 blades 78 against which a stream of warm air front an external source may be directed to drive it by means of an air inlet 79 mounted in the upper section of the casing 12 and having a restricted nozzle 80 for increasing the 105 velocity of the incoming air stream The disposition of the air inlet 79 and nozzle 80, with respect to the turbine blades 78, is arranged so that the air stream will impinge efficiently on the turbine blades, which are 110 illustrated in detail in Fig 5. The collar 75 on which the turbine is mounted has a tapered rearwardly extending portion 75 ' having a frusto conical friction pulley 81 mounted on it The pulley 81 115 bears on a second conical or dish-shaped pulley 82 having a central bearing 83 mounted on the forward end 84 of a stub shaft 85 slidably mounted within a bushing 86 which is in turn bolted to an upstanding post 87 120 secured to the bottom of the outer casing 11. A leaf spring 88 has one end secured to the post 87 and the other end bearing on the free end of the stub shaft 85 to bias it to the right as viewed in Fig 4 and to force the pulley 125 82 into engagement with the friction pulley 81 on the turbine. The pulley 82 constitutes an idler pulley between the conical friction pulley 81 and a similar conical friction pulley 93 mounted on 130 786,134 a frusto-conical sleeve 89 secured to a lay shaft 90 by means of a transverse pin 91 The lay shaft 90 has its front end mounted within a thrust bearing 92 which in turn is mounted within a cup 92 ' secured to the upstanding post 71 The other end 94 of the lay shaft 90 is of reduced diameter and is mounted in a bearing 95 secured to a bracket 96 mounted on the lower wall of the casing 11. Also mounted on the lay shaft 90 is a further conical friction pulley 100 mounted on a conical sleeve 97 which is secured against rotation

relative to the shaft 90 by means of a key 99 The key 99 is mounted within a keyway 98 so that the pulley 100 can slide longitudinally relatively to the lay shaft 90. Surrounding the lay shaft between the pulleys 93 and 100 is a coil spring 101 which biases the pulley 97 into frictional engagement with the outer flanged ring 65 of the end of the tumbler drum 31. Thus it will be appreciated that there is a frictional pulley drive between the turbine 77 and the tumbler drum 31 By virtue of the conical pulleys and the thrust bearings, automatic compensation for wear is obtained and a constant frictional engagement between the pulleys is always maintained, the leaf spring 88 biasing the idler pulley 82 into engagement with pulleys 81 and 93 and the coil spring 101 biasing the pulley 100 into engagement with the annular member 65 With the exception of the different drive to the tumbler drum, the operation of this embodiment is identical with that of Figs 1 to 3.

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* GB786135 (A)

Description: GB786135 (A) ? 1957-11-13

Substituted cyclopentyl compounds

Description of GB786135 (A) Translate this text into Tooltip

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The EPO does not accept any responsibility for the accuracy of data and information originating from other authorities than the EPO; in particular, the EPO does not guarantee that they are complete, up-to-date or fit for specific purposes.

COMPLETE SPECIFICATION Substituted'Cyclopentyl'Compounds We, CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT, a body Corporate organised under the laws of Germany, of 16 Frankfuri / M. - Fechenheim, Germany, do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is ta be performed, to be particularly described in and by the following statement: This invention comprises new substituted cyclopentyl compounds useful for therapeutical purposes, and a process for their manufacture. According to the invention the new compounds are cyclopentyl acetic acid amides, containing substituents, obtainable by condensing compound of the general formula : <img class="EMIRef" id="026415659-00010001" /> wherein R is hydrogen, alkyl (including aralkyl and cycloalkyl) or aryl, and X is halogen, hydroxy or alkoxy, with NH-compounds, such as ammoniacs primary or secondary amines or ureas. The new compound are valable intermediatesX especially for the manufacture of therapeutical agents, but they may also be used themselves as therapeuticals owing to their good sedative action. The following Examples are given for the purpose of illusrating the invention, the temperatures being in degree Centigrade. EXAMPLE 1. (CYCLOPENTYL-BROMO-ACETAMIDE) a) Cyclopentyl-bromo-acetic acid. 384 grams = 3 moles of cyclopentyl acetic acidi (boiling point at a pres sure of 18 millimetres of mer cury : 125-127 ; index of refraction nb2l =1. 4539) are intimately mixed with 31grams=1 mole of red phosphorus, and 680 grams = 8. 5 gram atoms of bromine are added dropwise. The temperature of the reaction mixture rises spontaneously with the liberation of hydrogen bromide. The mass is subsequently heated in a boiling water bath. The reaction is completed when no more vapour of bromine is to be found in the condenser. The mass is poured iMi twot litres of water and ! the whole is alowed to stand for two hours. The cyclopentyl-bromo-acetic acid, separated in ghe form of a bright-yellow heavy oil, is taken up in 500 millilitres of ether, washed thrice with 250 nitres of water each time, and is dried over calcined sodium sulphate. After removing the ether by distillation, the residue is distilled in the vacuum. The cyclopentylbromo-acetic

acid distils over at a pressure of 0.8 millimetre of mercury at 115 as a colour less oil which soon crystallises. Melting point: 46-47 . b) Cyclopentyl-bromo-acetylchloride. 207 grams = 1 mole of cyclopentyl-bromo acetic acid are boiled with 179 grams = 1.5 moles of thionylchooride for 5 hours unde reflux. Upon cooling, the excess of thionylchoride is removed by distillation in vacuo at 40 and the residue is fractionated. The cyclopentylbromic-acetylchloride distils over at a pressure of 8 millimetres of mercury at 90-92 as a colourless liquid. c). Cyclopentyl-bromo-acetamide. 225 grams = 1 mole of cyclopentyl-bromo acetylchoride are added drop wise during 2 hours at room temperature, whilst stirring, into 800 millilitres of a concentrated aqueous solution of ammonia. The mass is stirred for another hour, and the cyclopentyl-bromoacetamide, separated as white crystals, is filtered by suction. It is washed several times with water and crystallised from water or ben, zene. The cyclopenftyl-bromo'-aoetamide cry- stallisss in the form of beautiful, white, felted needles of melting point of 123-125 . The cycopentyl-bromcacetamide has a good sedative action. Its therapeutical index is 22.50 whereas that of the known diethylbromoWacetureide is anly 10. 05. In an analogous manner there is obtained from cyclopentyl-chloro-acetic acid, with the intermediate formation of acid chlroide or of an ester, cyclopentyl-chloro-acetamide which possesses analogous properties. EXAMPLE 2. (CYCLOPENTYL-BROMO-ACETYL-UREA) 112.5 grams=0.5 mole of cyclopentyl bromo - acetylchloride are added dropwise to a suspen sion of f 33grams=0. 55 mole of fin ; Iy pulverised urea in 500 millilitres of absolute benzene and the mass is boiled for 8 hours under reflux. Upon cooling, the crystallised cyclopentyl-bromo- acetylurea is filtered by suction and washed with benzene. It crystallises from benzene in the form of white prisms of a melting point of 145-146 . EXAMPLE 3.

(CYCLOPENTYL-YL-BUTYL-BROMOACETAMIDE) a) Cyclopentyl-n-butyl-bromo-acetic acid 55. 2 grams = 0. 3 mole of cyclopentyl-n butyl-acetic acid (boiling point at a pressure of 15 milli- metres of mercury: 155 ; index of refrction nD20 = 1. 4583) are intimately mixed 3. 1 grams =0. 1 mole of red phosphorus and reacted as described in Example 1 a) with 68 grams = 0.85 gram atom of bromine. After pouring the mass into 200 millilitres of wter, the cyclopentyl-n-butyl-bromo-acetic acid, separated as a bright-yellow heavy oil, is taken up in ether, which is dried over calcined sodium sulphate and then completely removed by distillation in vacuo. The residue is further processed without an additional purification. b) Cyclopentyl-n-butyl-bromo-acetyl chloride 52.6 grams=0.2 mole of cyclopentyl-n butyl - bromo - acetic acid (crude product) are boiled with 36 grams=0.3 mole of thionylchloride for 3 hours under reflux. The further processing is carried out according to Example 1 b). The cyclopentyl-K-butyl-bromo-acetyl chloride distifs over a pressure of 9 millimetres of mercury at 133-138 as a colourless liquid. c) Cyclopentyl-n-butyl-bromo-acetamide 56 grams=0.2 mole of cyclopentyl-n butyl - bromo - acetyl - chlor ide are added dropwisc at room temperature, with stirring, to 150 millilitres cf a concentratcd aqueous solution of ammonia. After stirring for 1 hour, the cyclopentyl-n-butyl-bromo-acetamide, which has at first separated as a coluorless oil, is taken up in ether. The ether solution is washed with water until neutral, and dried over calcinez sodium sulphate. After remov- ing the ether by distillation, a colourless oil remains, which crystallises after being placed in ice. Recrystallised from a little ether, the cyclopentyl-n-butyl-bromo-acetamide melts at 46-47 . In an analobous manner there may be obtained, for instance:

cyclopentyl-n-propyl-bromo-acetamide, di-(cyclopentyl)-bromo-acetamide (melt ing point : 59-60 ), cyclopentyl-benzyl-bromo-acetamide (meeting point : 134 ), and cyclopentyl-phenyl-bromo-acetamide. EXAMPLE 4. (CYCLOPENTYL-BROMO-DIBUTYL- ACETAMIDE) <img class="EMIRef" id="026415659-00020001" /> 25.8 g=0.2 mole of dibutylamide are dissolved in 300 ccm of absoute ether. 22.6 g=0.1 mole of cyclopentylbromo-acetyl-chloride are allowed to drop^ in, the mass being cooled with ice and stirred at the same time. The dropping in of all of the cyclopeWyl-bromo-acetyl- chloride having been finished, the mass is stirred under reflux for 2 hours. When the mass has been cooled, exhaustion by suction from the precipitated dibutylamine-hydrochloride takes place, the ether is washed with water, a little diluted hydrochloric acid, then again with water and is dried over calcine sodium sulphate. The ether is then distilled and the residus is fractionated in vacuo. The cyclopentyl-bromo-dibutylacetamide at boiling point 0.5 140 -150 distils as a colourless oil. nD20 = 1. 4356 sg. = 1. 025 The calculated molar refraction was 80. 894. The found molar refraction was 81. 09.

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* GB786136 (A)

Description: GB786136 (A) ? 1957-11-13

Improvements in shuttering for casting beams, columns, walls, etc. in situ

Description of GB786136 (A)

PATENT SPECIFICATION Inventor: PETER WILLIAM CHRISTENSEN 786136 e Date of Application and filing Complete Specification Jan 24, 1956. No 2282156. Complete Specification Published Nov 13, 1957. Index at Acceptance:-Class 20 ( 2), C 4 (A: G: K). International Classification: -E 04 g. COMPLETE SPECIFICATION Improvements in Shuttering for Casting Beams, Columns, Walls, Etc in Situ We, UNION JOINERY AND IMPORTING COMPANY LIMITED, of SA, Steele Street, Steeledale, Johannesburg, Union of South Africa, a company incorporated in the Union of South Africa, do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement:- This invention relates to shuttering for casting beams, columns, walls, etc in situ and has especial utility in the construction of beams and columns. In the construction of shuttering for casting in situ concrete beams or columns, it is usual to build up the shuttering from panels each of which itself provides the full width of one of the moulding faces Either the panels are tailored to the job, or standard panels, wider than they need be, are assembled edge to face to define between them a moulding space 6 f the required dimensions. Both of these procedures have disadvantages The object of the present invention is to provide a shuttering system which avoids such disadvantages. According to the invention, a method of erecting shuttering for casting in situ a concrete beam, column, etc, the width of a face or faces of which is an element or elements of the arithmetical progression a, a+d, a+ 2 d, a + 3 d consists in building up, in respect of each flat face of the beam, column, etc, a shutter of the correct width by selecting units from a set of panels consisting of or including a units of two standard widths, viz and 2 a -Ad, assembling them edge to edge to pro2 vide collectively the moulding face of the shutter; and securing together the several panels to define the moulding space between lPrce 3 s 6 d l them If a= 6 and d= 1, the panel widths be 3 and 4 units, any shutter can be produced in the ordered set 6, 7, 8, 9, 10, If the unit be one inch then any column or beam the widths of the faces of which are to be integers of 6 " or above can be cast by selection of panels of the set. To enable the panels to be assembled side by side each is made channel-shaped, the outerface of the web constituting the moulding

face and the flanges being formed with a standard pattern of holes through which bolts are passed to secure adjacent panels together. At the corners the meeting edges of the composite panels may be connected by bolting their outer flanges to angle irons. The assembled shuttering is secured against distortion by the bursting pressure of the concrete fill by being clamped at spaced intervals around its periphery To locate the clamps, the angle irons at the corners may be edgenotched to engage the clamps. Further to stabilise the assembly, cross ties may be provided which extend through the panels. An embodiment of apparatus according to the invention for the casting of columns is shown in the accompanying drawings in which:Fig 1 is an elevation of one form of shuttering for casting a column; Fig 2 is a plan view of Fig 1; Fig 3 is an elevation of a stay for supporting the column; Fig 4 is a fragmentary plan view of an alternative construction drawn to an enlarged scale; and Fig 5 is a perspective view of a typical panel. The basic shuttering units illustrated are a set of narrow panels 10, 11, of sheet metal, those 10 being 3 " and those 11 being 4 " in width Each panel is channel-shaped, the outer face 12 of the web constituting the so moulding face The flanges 13 may have short return flanges 13 x to stiffen the panels. The flanges 13 are formed with a uniformly spaced series of holes 14 through some of which bolts 15 are passed to secure adjacent panels together The panels are formed with slotted holes 16 to pass hoop iron cross ties 17 (see Fig 42 which serve to tie the opposed shutter walls 18, 19 and 20, 21 together. The several panels 10 and/or 11 which are assembled together to form the walls 18, 19, and 21 are selected from the set of panels collectively to provide a wall of correct width. Any girder or beam may be catered for provided it is an integral number of inches in both width and depth. The meeting edges of the walls 18-21 are secured together by bolting their outer flanges 13 a to angle irons 22 which may have limbs joined by an oblique base 22 X as shown in Fig 2, and which are preformed with a standard pattern of holes 24 to register with the holes 14 of the flanges 13 a. Chamfered corners may be formed on the beam or column as illustrated in Figs 1 and 2 or square corners may be formed by substituting appropriately shaped corner irons 22 a for the angle irons, 22, as shown in Fig 4. In so far as the lengthwise dimension of the shuttering is concerned, it is desirable to stagger the lateral joints 25 To this end the panels 10, 11 are provided in two lengths; one preferably twice that

of the other, say 3 feet and 6 feet, so that, two lengths of panel are alternated, in the lateral direction of the shuttering, at the top and bottom of the shuttering. Additional stability is imparted to the shuttering assembly by clamping it around its periphery at spaced intervals along its length, for instance by means of clamps consisting in a rectangular structure made up of bars 26, each bar slidable within an eye 26 a on a neighbouring bar and providing an eye for the other neighbour; the bars being forced around the shuttering to wedge the bars in the eyes To facilitate location of the clamps the edges of the irons 22 or 22 a may be notched along their length as shown at 27. Stays 28 for supporting the shuttering may be provided These are preferably easily adjustable in length, for instance by being composed of two or more telescoping tubes, 29, 30 connected together by cross bolts 31 through registering holes of a series of holes 32, 33 in the tubes; the final adjustments being made by plumbing screws 34. The stays are conveniently connected to the shuttering by providing at the upper end of each stay a hook or eye 35 which is clamped by one of the bolts 36 that connects a flange 13 a to the iron 22 or 22 a.

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* GB786137 (A)

Description: GB786137 (A) ? 1957-11-13

Improvements in wheeled carriers for baskets and like holders

Description of GB786137 (A)

_: = PATENT SP-ECIFICATION Inventor: BENJAIN JOYN STANS Bl E 78 f i Date of Application and filing Complete Specification: Feb 1,

1956. No 3213/56. Complete Specification Published: Nov 13, 1957. Index at acceptance:-Class 108 ( 1), E 4. International Classification:-B 62 b. COMPLETE SPECIFICATION Improvements in Wheeled Carriers for Baskets and like Holders We, B J S CASTINGS i(BIRMINGHAM) LIMITED, a British Company of 3, Lozells Road, Birmingham, 1 '9, in the County of Warwick, do hereby declare the invention, for which we pray that a Patent may be granted to us, and the method by which it is to be performed, lo be particularly described in and by the following statement: - This invention relates to wheeled carriers adapted to support baskets or like holders, such as for example fishing or shopping or picnic baskets, to enable their baskets and their contents to be easily moved from place to place. It is an object of the present invention to provide a wheeled carrier for baskets or the like and which 'can be dismantled for storage or other purposes. According to the present invention a wheeled carrier for baskets and like carriers comprises a rigid body or frame providing a surface adapted to support one side of a holder and also providing a platform disposed transversely to said surface and adapted to support the base of the holder, the body or frame being arranged so as not to present restriction to the width of the holder in a plane parallel with said surface 'of the body or frame and which latter is provided with means whereby the holder can be secured thereto, and the body or frame being arranged to support la pair of axles disposed parallel with said surface of the body or frame and each carrying a ground engaging wheel, the axles being supported by the body or frame in a manner enabling the width of the track of the wheels to be adjusted to suit different sizes of holders and enabling the axles and wheels to be removed from 'the body or frame, and said body or frame being adapted to receive a handle for propelling the carrier. The body or frame is preferably of considerably smaller dimensions in thickness as viewed in side elevation than in front elevation so that when ia basket or holder is attached to the carrier from which the wheels have been removed the body or frame does not project to any significant degree from the basket or holder. The invention will now be more particularly described with reference to the accompanying 50 drawings in which, Figure 1 is a perspective view of a wheeled carrier showing one wheel and stub axle in dotted lines to indicate that these parts are removable and showing also a basket and 55 handle in dotted lines:

Figure 2 is a fragmentary sectional view taken on the lines 2-2, of Figure 1: and Figure 3 is a fragmentary sectional view taken on the lines 3-3 of Figure 1 60 The wheeled carrier, generally indicated at 10, has secured' thereto a, rectangular basket 11 having a lid at its upper end and four legs 12 A handle 13 ' is mounted on the wheeled carrier so that said carrier and the 65 basket lcan be propelled from place to place. The wheeled carrier includes a frame which may conveniently be cast in one-piece and comprises a base bar 14, two spaced apart side bars 15 which converge (and are connected 70 at their upper ends in the vicinity of a lug 16, and a central bar 1,7, and said bars are conveniently ribbed for strengthening purposes. Secured in the lug 116 is a screw-threaded 75 stud 18 to which can be attached the handle 13 and conveniently when the basket 11 is of the kind used by fishermen the handle 13 may be formed by the handle of 'a landing net as 'commonly used by fishermen 80 Projecting forwardly of and integrally with the base bar 14 is a platform'19 which extends $or the length of the base bar and at right jngles to the plane containing the bars of the frame, said platform being arranged so that 85 the base of the basket 11 may rest thereon with the back of the basket lying against the frame The platform 19 and 'the 'converging parts of the side bars 15 are provided with holes 20 for attachment screws 2:1 which are 90 adapted to pass through the base and rear wall of the basket and have nuts applied thereto to clamp the basket to the frame If desired the holes 20 may be elongated to enable the attachment screws 21 to be positioned to suit 95 the construction of the basket. 64137 At each end of the base bar 14 there is integrally formed with said bar a boss 22 which is bored at 23 to receive a stub axle 24 The bores 23 are co-axially and horizontally disposed and are circular in crosssection to receive the stub axles 24 which are also circular in cross-section, and a screwthreaded set pin 25 is mounted within each boss 22 so that its inner end enters the bore 23 to impinge upon the stub axle 24 and lock said axle in position. On one end of each stub axle 24 is mounted a ground engaging wheel 26 and the ground engaging wheels of the two axles are of such diameter as to elevate the legs 12 of the basket above the ground when the carrier is in a substantially upright position. In use when it is desired to put the carrier into use a basket is secured to the frame by the attachment screws 20 and the two stub axles are then inserted into the bosses 22 each to an extent such that the wheels 26 are disposed adjacent the ends of the basket and the axles are locked in these two positions by tightening the set pins 25 on to the axles A handle 13 such as before described is mounted on the stud 1 i 8 and the carrier and basket can then be wheeled in an easy

manner to the desired place Upon reaching the desired location which may for example be a position from which a fisherman desires to operate, the wheels 26 and the stub axles can be removed from the frame after releasingthe set pins 25 and said wheels and axles can then be placed within the basket The legs 12 ef the basket then rest upon the ground and this prevents any accidental movement of the basket or easy unwarranted removal by a person other than the owner It will be appreciated that in this dismantled condition of the carrier, said carrier and the basket can be easily carried from place to place such as when the user is making bus or train journeys, in a more convenient manner than if the carrier were assembled. To protect the stud 18 when the handle 13 is not applied thereto a cap nut, not shown, may be screwed on to said stud 18.

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* GB786138 (A)

Description: GB786138 (A) ? 1957-11-13

New ergot alkaloid derivatives and process of making same

Description of GB786138 (A) Translate this text into Tooltip

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PATENT SPECIFICATION

7863138 go Date of Application and filing Complete Specification: Feb 3, 1956. No 3537156. Application made in Switzerland on Feb 4, 1955. Complete Specification Published: Nov 13, 1957. Index at acceptance:-Class 2 ( 3), C 2 821, C 2 B 37 (C 1: C 3: I: L). International Classification:-CO 7 d. COMPLETE SPECIFICATION New Ergot Alkaloid Derivatives and process of making slame We, SANDOZ LTD, of Lichtstrasse 35, Basle, Switzerland, a Swiss Body Corporate, do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it isq to be performed, to be particularly described in and by the following statement: - The present invention relates to process for the production of derivatives of ergot alkaloids. It has been found that hitherto unknown derivatives of ergot alkaloids may be obtained by exposing an aqueous solution of ergot alkaloids or their derivatives having a double bond in 9,10-position of the lysergic acid radical to light. It has been known for some time that the alkaloids of ergot are extremely sensitive substances which by the action of chemical agents as well as under the influence of light undergo changes; these changes reduce their physiological effect or even result in decomposition of the substance However, the decomposition products of ergot alkaloids and their above mentioned derivatives resulting by the action of light have not been isolated or described hitherto. It has now been found that by exposing aqueous solutions of ergot alkaloids and other derivatives of lysergic or iso-lysergic acid to light there may be obtained well defined derivatives which differ from the starting materials in that they have one double bond less It has further been found that the double bond present in the starting material has disappeared owing to the substitution of a hydrogen atom on one carbon atom and of a hydroxyl group on a neighbouring carbon atom, said two carbon atoms having previously been linked by said double bond. Thus in accordance with the present invention a process for the production of hitherto unkmown derivatives of ergot alkaloids is characterized in that the aqueous solutions of ergot alkaloids or other derivatives of lysergic or isolysergic acid containing a group -CON< and having a double bond in the 9,10-position of the lysergic acid radical are lnca exposed to light for a period of time and at a temperature such that the said double bond in at least some of the molecules of the starting material is replaced by water, and the resulting reaction products are recovered by methods known for, the

recovery of alkaloids. The word " known " designates methods described in the literature on the subject or in actual use. The temperature at which the reaction should be effected is 2-60 C; below 2 C. the reaction proceeds at a very slow rate and above 60 C the reaction products may be adversely affected. The invention also includes the compounds obtained by the said process, especially the compounds produced in the examples and the table given hereinafter. The process may be carried out, for example, in the following manner: A solution of ergotamine in glacial acetic acid is diluted with water and exposed to light for a prolonged time, e g 3-40 hours The solution is made alkaline with ammonia and then extracted with chloroform, and the residue resulting from evaporation of the chloroform extract is chromatographed on aluminium oxide. The new compounds are solid crystalline bases at room temperature On account of the manner of the production of the new compounds they have been designated lumiderivatives, e g lumi-ergotamine, lumi-ergotaminine and lumi-lysergic acid diethylamide. Whereas solutions of natural ergot alkaloids and their dextro-rotatory isomers exhibit blue fluorescence in ultra-violet light, this phenomenon is reduced or disappears with the lumi-derivatives In this respect, they are very similar to the derivatives of the dihydrolysergic and dihydro-isolysergic acid series. The lumi-derivatives give a characteristic colour-reaction with concentrated sulphuric acid: A deep violet-blue colour is instantly produced which fades after about 2 minutes. In Keller's colour-reaction the lumi-derivatives give the same deep violet-blue colour as the starting materials The fastness to light of the lumi-derivatives is particularly good. The following examples illustrate the invention without limiting it The lumi-derivatives produced in the examples have therapeutically useful pharmacodynamic properties; they have a contracting effect on the uterus and show a sympathicolytic action greater than the starting materials and may be used in the treatment of mental disturbances. EXAMPLE 1. A solution of 4 g of ergotamine in 50 cc of glacial acetic acid is diluted with 450 cc of distilled water and exposed to direct sunlight in a thin-walled transparent vessel for 30 hours whereby the temperature rises to about 30 C. The black-brown solution which is no longer blue-fluorescent in the ultra-violet light is made alkaline with concentrated ammonia and exhaustively extracted with chloroform The chloroform extract after

drying with sodium sulphate is evaporated to dryness and a S 6 luticn of the residue in 30 cc of chloroform containing 1 per cent of ethanol is chromatographed on a column of 300 g of aluminium C 3,,H 70,N, Calc C 66 09 ( 599 67) Found 65 76 lAD 20 = + 14 KELLER'S COLOUR REACTION: 0 1 rug of substance dissolved in 1 cc of glacial acetic acid containing a trace of ferric chloride shows on introduction of 1 cc of concentrated sulphuric acid underneath the substance and shaking a fast intensely blue colour. COLOUR REACTION WITH CONCENTRATED SULG,,H,,0,N, Calc C 66 09 ( 599 67) Found 65 74 lA 20 = + 20 KELLER'S COLOUR REACTION: deep blue. COLOUR REACTION WITH CONCENTRATED SULPHURIC ACID: violet, rapidly fading. EXAMPLE 2. A solution of 2 4 g of ergotaminine in 24 cc of glacial acetic acid is diluted with 215 cc of distilled water and exposed to the light of a mercury vapour lamp in a thin-walled transparent vessel at a temperature of 26 ' C for 31 hours From the bluish green solution which in ultra-violet light exhibits only slight greyish blue fluorescence, the alkaloids are precipitated by the addition of concentrated ammonia and exhaustively extracted with chloroform The chloroform extract is dried with sodium sulphate and evaporated to dryoxide; the chromatogram is developed with more solvent having the same composition. After a total of 200 mg of substance has been eluted, chromatography is interrupted and the chromatogram is then divided into zones. from the upper two-thirds, 3 2 g of a brownred substance is eluted which yield, after being taken up in methanol, 2 6 g of crude crystalline lumi-ergotamine (I) having a melting point of 233-237 C lCl = + 13 ' (c= 0 3 in pyridine) the lower third of the column yields on elution 100 rug of substance from which, after being taken up in a small quantity of acetone, 65 mg of crude crystalline lumiergotamine (II) are isolated The filtrate of the column yields a further 140 mg of crude crystalline lumi-ergotamine (II). From the solution of the crude lumi-ergotarmine (I) in chloroform/methanol (ratio= 1:1), after evaporation of the chloroform, pure lumi-ergotamine (I) crystallises in strongly refractive wedge shaped prisms; melting point 247 ' C The product is barely soluble in commonly used organic solvents and a little more readily soluble in pyridine and glacial acetic acid. H 6 22 O 16 01 N 6.20 16 20 (c = 0 4 in pyridine) 11.68 % 11.40 % PHURIC ACID: 0 1 mg of very finely pulverised substance with 0 5 cc of concentrated sulphuric acid immediately produces a deep violet blue shade which fades within 2 minutes Lumi 65 ergotamine (I) crystallises from acetone in polyhedra containing solvent of crystallisation,

melting point 192 ' C. H 6 22 O 16 01 N 6.25 15 72 (c = 0 6 in pyridine). 11.68 % 11.26 % ness and the solution of a residue in 50 cc of chloroform containing 1 per cent of ethanol is chromatographed on a column of 300 g of 90 aluminium oxide; the chromatogram is developed with more solvent having the same composition whereby several zones are formed which show blue, yellow, red and green fluorescence in ultra-violet light Chromato 95 graphy is interrupted as soon as the first traces of alkaloid can be detached in the filtrate and the chromatogram is then divided into zones. From a homogeneous zone of the lower third of the column 500 mg of brown substance are l Or eluted which yield from methanol 390 mg of crude crystalline lumi-ergotaminine (I) with the specific rotation l 4 J' = + 60 ' (c = 0 5 in pyridina) The eluate of the lowest blue786,138 786,138 3 fluorescent zone yields 185 mg of residue from which, after being taken up in methanol, 90 mg of unchanged ergotaminine crystallises out. From the upper third of the column which exhibits a greyish blue fluorescence in ultraviolet light 540 mg of dark brown lumi-ergotaminine (II) are eluted which, after being taken up in methanol and after the addition of water, crystallise in flat plates having a specific rotation laclD 2 = 11 ' (c= 0 4 % in pyridine). From the solution of the crude lumi-ergotaminine (I) in chloroform/methanol (ratio 1: 1) there crystallises after evaporation of the chloroform the substance containing i mol of chloroform of crystallisation in the form of colourless polyhedra, melting point 217 ' C. C,,H,,0,N, CHCI, Calc C 61 02 H 5 73 O 14 56 N 10 62 % ( 659 36) Found 61 15 5 77 14 81 10 28 % The chlorine content was not determined. llD 20 = + 68 (c = 0 4 in pyridine). KELLER'S COLOUR REACTION: deep blue. COLOUR REACTION WITH CONCENTRATED SULPH 1 URIC ACID: violet, rapidly fading. Lumi-ergotaminine (II) crystallises from a C,,H,706 N, Calc C 66 09 H 6 22 ( 59 67) Found 65 76 6 01 ll 20 = 12 ' (c = O 6 KELLER'S COLOUR REACTION: deep blue. COLOUR REACTION WITH CONCENTRATED SULPHURIC ACID: violet, rapidly fading. EXAMPLE 3. A solution of 1 4 g of ergometrine in 14 cc of glacial acetic acid is diluted with 130 cc of distilled water and exposed to the light of a mercury vapour lamp in a thin-walled transparent vessel at a temperature of 250 C for hours The resulting bluish green solution which does not exhibit any longer a blue C 1,,10,N, Calc C 66 45 ( 343

41) Found 66 12 lAD 2 = 28 lD 2 = 18 KELLER'S COLOUR REACTION: deep blue. COLOUR REACTION WITH CONCENTRATED SULPHURIC ACID: violet, rapidly fading. EXAMPLE 4. A solution of 2 g of lysergic acid diethylamide in 200 cc of glacial acetic acid is diluted with 1800 cc of distilled water and exposed to the light of a mercury vapour lamp in a thin-walled transparent vessel for 6 hours. The resulting slightly yellowish brown solution which does not any longer exhibit fluorescence in ultra-violet light, is made alkaline with concentrated ammonia and C 20 H 270,N, Calc C 70 36 ( 341 44) Found 70 44 l 90 O 29 la 20 = _ 2930 lAD 20 = _ 23 c I 7 34 7.29 :c = 0 5 c 05 iol solution of the crude product, after dition of water, in the form of colourexagonal plates containing crystal solhaving a melting point of 2280 C. O 16 01 N 11 68 % 16.01 11 46 % in pyridine). scence in ultra-violet light, is made alkawith an aqueous sodium hydroxide soluand, after being saturated with common exhaustively extracted with chloroform. drying, the chloroform solution yields uaporation 810 mg of crude crystalline -rgometrine having a melting point of C., l-l-= -27 " (c= 0 4 in pyridine). compound crystallises from methanol on, after the addition of water, in the of colourless oblique prisms having a ng point of 156 C. o 13 98 N 12 24 % 13.59 12 09 % in pyridine) in methanol). exhaustively extracted with chloroform The chloroform solution is dried and leaves a residue after evaporation, the solution of which in chloroform containing 0 5 per cent of ethanol, is chromatographed on a column of 300 g of aluminium oxide At first, traces of unchanged fluorescent starting material pass through the column whereupon a zone containing 1 7 g of colourless non-fluorescent substance enters the filtrate This crude product yields on re-crystallisation from boiling benzene 1 g of crystalline lumi-lysergic acid diethylamide (I) having a melting point of 2230 C. H 7 97 8.10 (c = 0 3 (c = 0 4 O 9 37 N 12 30 % 9.48 12 27 % in pyridine) in chloroform) 786,138 KELLER'S COLOUR REACTION: deep blue. COLOUR REACTION WITH CONCENTRATED SULPHURIC ACID: violet, rapidly fading. From a non-fluorescent zone of the upper part of the chromategram there are obtained C 2,H 27,0 N, Calc C 70 36 ( 341 44) Found 70 45 lal 20 = _ 750 KELLER'S COLOUR REACTION: deep blue. COLOUR REACTION WITH CONCENTRATED SULPHURIC ACID: violet, rapidly fading.

mg of crude lumi-lysergic acid diethylamide (II) The compound crystallises from a chloroform-methanol mixture (ratio 2: 1) in the form of long thin prisms having a melting point 256 C 10 H 7 97 7.80 (c = 0 2 O 9 37 N 12 30,' 9.57 12 12 % in pyridine). The following table shows further lumiderivatives of lysergic acid which were produced in manner similar to the one described above: Type of crystals Substance and melting point after crystallisation empirical (with decom lal 20 D in from the solvent formula position) pyridine stated Lumi-lysergic 2410 C + 20 prisms from acid (I) methanol hydrazide (c = 0 5) C 16 H 2002 N 4 Lumi-isolysergic 2440 C 540 polyhedra acid (I) from hydrazide (c = O 2) methanol C 16 H 2002 N 4 Lumi-methyl 1950 C -32 long prisms ergometrife (I) from ethyl lalternative name-: lumilysergic acid-butanolamide -2 (I)6 l acetate (c = 0 5) C 20 H 2703 N 3 Lumi-ergosine 2050 C + 300 needle shaped (I) crystals from (c = 0 4) ethyl acetate C 30 H 3906 N 5 Lumi-ergo 2020 C + 32 polyhedra cornine (I) from ethyl (c = O 6) acetate C 31 H 4106 N 5 Lumi-ergo 1953 C + 18 prisms having cristine (I) two pointed (c = O 6) ends from benzene C 35 H 4106 N 5 Lumi-ergocryp 2010 C + 390 polyhedra tine (I) from ethyl (c = O 8) acetate C 32 H 4306 NS 786,138 taining acetone as solvent of crystallisation after crystallisation from acetone. 7 Dextro rotatory lumi-ergotamine (I) having the empirical formula CQSH 3,0 N, and having a melting point of 2470 C when crystallised from a mixture of chloroform/ methanol in the proportion 1:1. 8 Laevo'rctatorylumi-ergotaminine (II) have ing the empirical formula C,3 H 07 06 N, and having a melting point of 2280 C when containing methanol as solvent of crystallisation after crystallisation from methanol. 9 Dextro rotatory lurmi-ergotaminine (I) having the empirical formula CH,,0,74 N, and having a melting point of 2170 C when containing a half molecule of chloroform as solvent of crystallisation after crystallisation from a mixture of chloroform/methanol in the proportion 1: 1. Laevo rotatory lumi-ergometrine having the empirical formula C,,H 20,QN, and having a melting point of 1560 C after crystallisation from methanol. 11 Laevo rotatory lumi-lysergic acid diethylamide (I) having the empirical formula C 20 H 2702 N, and having a melting point of 2230 C after crystallisation from boiling benzene. 12 Laevo rotatory lumi-lysergic acid diethylamide (II) having the empirical formula Cf O HIO 2 N, and having a melting point of 2560 C after crystallisation from a mixture of chloroform/methanol in the proportion 2:1. 13 The compounds set out in the table given herein having the

empirical formulae stated in said table and having the melting points (with decomposition) stated in said table after crystallisation from the solvents stated in said table. MEWBURN, ELLIS & CO, & 72, Chancery Lane, London, W C 2, Chartered Patent Agents.

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