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the presentation

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Every relationship starts somewhere……

Combinations always does the best

Often Taking Naproxen Single is a Danger

Naproxen Sodium+ Esomeprazole Magnesium

Why Necessary

Dual Action, Dual Impact

Naproxen & Esomeprazole Modified-release tablet containing enteric-coated (gastro-

resistant) naproxen and film-coated esomeprazole.

Indications

Mechanism of Esomeprazole

Mechanism of Action of Naproxen Sodium

NSAIDs Action

Naproxen Works on Selected Areas of body

M/A of Proxen plus• Proxen Plus is a fixed dose combination of the proton

pump inhibitor esomeprazole magnesium, with the non-steroidal anti-inflammatory drug (NSAID) naproxen in a single tablet. Proxen Plus has been developed as a delayed release tablet whereby esomeprazole (20 mg) is released first in the stomach, prior to the dissolution of enteric-coated naproxen (500 mg) in the small intestine. The mechanism of action of the naproxen, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition. By acting specifically on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric acidity.

Dosing Information

• One tablet to be swallowed whole twice daily, taken 30 minutes before food.

Administration

Indigestion ,impaired sense of taste Inflammation of sinuses

Back pain, dizziness, cough,constipation Burning or discomfort of stomach, gas,

headache

Side Effects

Cautions

Global Leader’s Study

Why Not Omeprazole, Why we combine Esomeprazole

Present Market Scenario

Products Name Company

Market Share Sales Growth LaunchingYear

DINOVO Beximco 1.25% 84,145,873 22.48% 2011

XENOLE Square 1.03% 69,058,731 7.74% 2012

Naprosyn Plus Radiant 16.95%

145,535,32525.06% 2012

NAPROX PLUS Eskayef 3.33% 48,165,368 17.19% 2013

NAPRO-A-PLUS ACME 3.39% 49,054,797 33.81% 2012

Brand AnalysisBrand Name Contains Dosage Form Manufacturer Price(Tk.)

DEMOVO 375 Naproxen sodium 375mg & esomeprazole 20mg/tablet Tablet Delta Pharma

Limited375mg x 24s pack:

192.00 MRPDEMOVO 500 Naproxen sodium 500mg &

esomeprazole 20mg/tablet Tablet Delta Pharma Limited

500mg x 16s pack: 160.00 MRP

DINOVO 375/20 Naproxen sodium 375mg & esomeprazole 20mg/tablet Tablet

Beximco Pharmaceuticals

Ltd375mg x 50s pack:

400.00 MRP

DINOVO 500/20 Naproxen sodium 500mg & esomeprazole 20mg/tablet Tablet

Beximco Pharmaceuticals

Ltd500mg x 50s pack:

500.00 MRP

NAPXON 375 Naproxen sodium 375mg & esomeprazole 20mg/tablet Tablet

Ziska Pharmaceuticals

Ltd375mg x 32s pack:

256.00 MRP

NAPXON 500 Naproxen sodium 500mg & esomeprazole 20mg/tablet Tablet

Ziska Pharmaceuticals

Ltd500mg x 32s pack:

320.00 MRP

NESO-375 Naproxen sodium 375mg & esomeprazole 20mg/tablet Tablet Aristopharma

Ltd.375mg x 40s pack:

320.00 MRPNESO-500 Naproxen sodium 500mg &

esomeprazole 20mg/tablet Tablet Aristopharma Ltd.

500mg x 40s pack: 400.00 MRP

PROGESIC 375 Naproxen sodium 375mg & esomeprazole 20mg/tablet Tablet

Incepta Pharmaceuticals

Ltd375mg x 30s pack:

240.00 MRP

PROGESIC 500 Naproxen sodium 500mg & esomeprazole 20mg/tablet Tablet

Incepta Pharmaceuticals

Ltd500mg x 28s pack:

280.00 MRP

Key promotional Points

1) FDA approves this to treat Musculoskeletal Disorders after vigorous Study

2) Comparative effectiveness and safety of Proxen Plus against both meloxicam and celecoxib would be required for the following outcomes:

*Pain *Gastrointestinal outcomes *Cardiovascular outcomes3) 100% satisfactory for those patients who are at a risk of

NSAID-associated gastric and/or duodenal ulcers and where lower doses of naproxen or other NSAIDs are not sufficient.

Key promotional Points

• Safe for long term use up to one year.• Convenient & cost effective.

Target Customers

• Rheumatologists• Arthritis Specialist

• Orthopedics• Surgeons

• Gastroenterologists• Medicine Specialists

• GPs

Lowest dose can achieve the goals

Thanks

Ashikur RahmanProduct Executive

PMDMonicoPharma Limited