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Applied Bioinformatics & Chemoinformatics: Techniques, Tools and Opportunities.
FATOKI, Toluwase H.Department of Biochemistry,
Federal University of Technology, Akure, Nigeria. +2347032219821
[email protected] www.linkedin.com/in/hezekiahfatoki
www.fheztbioinformatics.wordpress.com
“None of us is as smart as all of us” – Ken Blanchard.“If you want to go fast, go alone. If you want to go far, go together.” – African Proverb.
OUTLINES• Introduction to Genetic Engineering• Sequencing: The Next Generation• Introduction to Bioinformatics• Overview of Bioinformatics in Africa• Essential Bioinformatics• Introduction to Database and Tools• Introduction to Chemoinformatics/Pharmacoinformatics• Applications of Bioinformatics• Application in Biotechnology Industries• Application in Biomedical and Biopharmaceuticals Industries• Current Trends and Opportunities• Questions and Answers
Introduction to Genetic Engineering
• The Central Dogma
• Concept Maps of Genetic Engineering
Sequencing: The Next GenerationA Life Decoded is the story of this singular milestone in our history, told by the man who through a combination of vision, tenacity, ingenuity, and insight challenged conventional wisdom and refuted his critics to reveal the human genetic code.
Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.
Introduction to Bioinformatics
Overview of Bioinformatics in Africa
Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.
Medha Bhagwat, PhD. NIH Library Bioinformatics Support Program
Essential Bioinformatics• Section I: Introduction And Biological Databases• Section II: Sequence Alignment• Section III: Gene And Promoter Prediction• Section IV: Molecular Phylogenetics• Section V: Structural Bioinformatics• Section VI: Genomics and Proteomics
Arthur M. Lesk,(2002). Introduction to Bioinformatics, Oxford University Press, New York
Introduction to Databases and Toolshttp://www.cbs.dtu.dk/biotools/http://molbiol-tools.ca/molecular_biology_freeware.htmhttp://www.hpc.cam.ac.uk/compbio/softwarehttp://bioinformaticssoftwareandtools.co.in/bio_tools.phphttp://www.bioafrica.net/software.php
• NCBI: The National Center for Biotechnology Information (USA): http://ncbi.nlm.nih.gov
• EBI:The European Bioinformatics Institute: www.ebi.ac.uk
• SIB:The Swiss Institute of BioinformaticsExpasy (Expert Protein analysis system): www.expasy.org
• Canadian Bioinformatics Resource http://cbr-rbc.nrc-cnrc.gc.ca/
Chemoinformatics/Pharmacoinformatics
Darren Green, (2016). Computational Drug discovery.
The computational methods for in silico drug discovery have been
broadly categories into two fields bioinformatics and chemoinformatics.
In case of bioinformatics, major emphasis is on identification and
validation of drug targets, mainly based on functional/structural annotation
of genomes.
In case of cheminformatics or pharmacoinformatics, major emphasis is
on designing of drug molecules or ligands and their interaction with drug
targets.
Frank K. Brown (1998) defined Chemoinformatics as the mixing of
information resources to transform data into information, and information
into knowledge, for the intended purpose of making better decisions faster
in the arena of drug lead identification and optimization.https
://fheztbioinformatics.wordpress.com/2017/02/04/bioinformatics-chemoinformatics-and-drug-discovery/
APPLICATIONS OF BIOINFORMATICS
Application in Biotechnology Industries
Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.
Application in Biomedical and Biopharmaceuticals Industries
Desmond S. T. Nicholl, (2008). An Introduction to Genetic Engineering. Cambridge University Press, New York.
Jurgen Drews (2000). Drug Discovery: A Historical Perspective, Science/Drug Discovery, vol.287, 1960-1964.
Current Trends and Opportunities
Jobs, PhDs and Networkshttp://blog.biogem.org/2013/03/bioinformatics-carrer-opportunities.htmlhttp://www.sib.swiss/about-us/careershttp://www.nature.com/naturejobs/science/jobs?q=bioinformaticshttp://www.bioinformatics.org/jobs/http://www.linkedin.com/topic/bioinformatics http://www.linkedin.com/topic/computational-biology Online Courseshttps://www.futurelearn.com https://www.coursera.org
Thanks for
listening
