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clinical & pathological effects of toxic plants.
Presented to - Dr. Divakaran Nair.Prof. & HOD, Dept. of VPP. COVAS, Pookode.
Course no. VPP-609.Toxicopathology.
Presented bySindhu K.
M. V. Sc. Scholar,Dept. Of VPT.
Overview
• Introduction• Classification of toxic plants• Clinical & pathophysiology of toxic plants• Plants producing various poisoning• Treatment & management of poisoning plants
Toxic plant may be defined as “one which detrimentally affects the health of man or animal when eaten in such amount as would be taken normally or under special circumstances like restriction of choice of diet or extreme hunger”.
EtymologyTOXIN Toxon (Greek) for bow & arrow Toxicon poison dipped arrow
POISON Poi to drink & becoming potare in
Latin (potion) Venomous nature derived from wen to
win, & led to venus/venerate through “love potions” (venin)
Sec. plant Metabolites• The toxic (active) principles present in the
plants = PHYTOTOXINS.• Plant toxins may be referred as SPM.• SPM defense mechanism / survival
adaptations.Toxic plants are of 2 types• Plant containing toxic ingredients & are
known to be toxic to animals.• Plants which are normally not toxic to animals
but becomes so under unfavorable conditions.
Classification of toxic plants
I. Alkaloids II. Terpenes III. GlycosidesIV. Proteinaceous compoundsV. Organic acidsVI. Resins & Resinoids
Tropane/atropine like alkaloids
Atropine
Datura (jimsonweed)Erythroxylum (coca tree)Hyoscyamus (henbane)Mandragora (mandrake)
Pyrrolizidine alkaloids
Retronecine
Senecio (ragwort)Crotalaria sp.Heliotropium sp.Trichodesma sp.
Pyridine/Piperidine alkaloids
Conium (Hemlock)Lobelia (Indian tobacco)
Pyrrolidine-pyridine alkaloids
Nicotine
Nicotiana sp. (Tobacco)Equisetum sp. (Horse tail)
Purine alkaloids
caffeine
Coffea sp. (Coffee)Theobroma sp. (Cocoa)Camellia sp. (Tea)
Quinoline alkaloids
Quinine
Cinchona sp. (Quinine tree)Echninops sp. (Globe thistle)
Isoquinoline alkaloids
Morphine
Papaver somniferum (opium)Sanguinaria sp.Dicentra (Blood root)
Indole/indolizidine alkaloids
Strychnine
Strychnus (strychnine)Claviceps (Ergot)Psilocybe (Magic mushroom)Astragalus sp. (locoweed)Gelsemium sp.
Quinolizidine alkaloids
Anagyrine
Laburnum sp. (Golden chain)Baptisia sp. (False indigo)Cytisus sp. (Scotch broom)
Steroidal glycoalkaloids
Solanidine
Lycopersicum sp. (Tomato)Solanum sp. (Nightshades)
Steroidal alkaloids
Jervine
Veratrum sp.Zigadenus sp.
Diterpenoid alkaloids
Aconitine
Delphinium sp. (Larkspur)Aconitum sp. (Monkshood)
Phenylamine alkaloids
Ephedrine
Lophophora sp. (peyote)Ephedra sp.
Terpenes Biosynthesized by plants
Contains the branched 5-carbon skeleton of isoprene.
On the basis of number of isoprene units present in the
structure of the molecule, terpenes are categorized as
C-10 compounds monoterpenes
C-15 compounds sesquiterpenes
C-20 compounds diterpenes
C-30 compounds triterpenes
Monoterpenes• Cantharidine an animal
monoterpene from fly ash.• Picrotoxin from Anamirta
cocculus (Fish berries).
Sesquiterpenes• Coramyrtin from Coriaria
myrtifolia• Geigerin from Geigeria• Helenalin from Helenium
microcephalum
Diterpenes• Andromedotoxin• Mezerein • Aconitine from Aconitum
sp.
Triterpenes• Cicurbitacins (toxic principles of
bittergourd)• Lantadenes from Lantana sp.
Glycosides Complex organic compounds having glycone attached to
aglycone/genin moiety by ether linkage
Neutral in reaction
Soluble in alcohol, less soluble in water & insoluble in
ether
They don’t combine with acids to form salts
Names ends with suffix –in.
Eg: digitoxin, ouabin, scillarin, glycyrrhizin, senegin.
Cyanogenic glycosides
Amygdalin
Amygdalin (Almond seed)HCN in Hydrangea, Linum (Linseed)Prunus (Wild cherry)Sorghum vulgare (Jowar) Sorghum sudanese (Sudan grass)Gossypol (cotton seed)
Steroidal (cardionilides/
cardiac glycosides) Digitoxin
Digoxin from Digitalis sp.Oubain from Strophanthus Convallarin from ConvallariaAscleipas (Milk weed)Nerium oleander
Steroidal (saponigenic glycosides)
Argostemme (Corn cockle)Phytolacca (Poke weed)Hedera (English ivy)
Coumarin glycosides
Esculin
Ausculus glabraMoldy Meliolotus sp. (White sweet clover)Ipomoea sp. (Sweet potato)
Anthraquinone glycosides
Cassia fistula (Senna)Aloe sp.
Mustard glycosides
Sinigrin
Thiocyanates/isothiocyanates of mustard oil.(Brasssica nigra)
Proteinaceous compounds Plant proteins = harmless + beneficial agents.
Plant protein + seed reserve proteins important source of
food.
Ingestion protein hydrolysis enzymatic reactions in GIT
absorption of amino acids protein biosynthesis in the body.
However; there are no. of proteins, peptides/amines which
are of toxicological importance.
Eg: toxalbumins, polypeptides, amines.
Toxalbumins (proteins)
• Abrin from Abrus precatorius
• Ricin from Ricinus communis
Polypeptides • Amatoxins, phallotoxins & phalloidin from Amanita sp.
Amines• Aminotryptaline from seeds of Sativus
odoratus• Phoradendron sp. (Berries of mistle
toe)• Mimosine from Mimosa pudica• Canavanine from Canavalia ensiformis
(Jack beans)• Leucaena leucocephala (Subabul)
Organic acidsAcids accumulated in plants, particularly in their fruits
but are non-toxic.1. Malic acid2. Tartaric acid3. Citric acid4. Ascorbic acidBut other plant acids possess significant toxic property
solely due to their acidityEg: plant oxalic acid & its soluble Na, K or NH4 salts.
Oxalic acid & soluble salts• Oxalic acid• Potassium oxalate• Sodium oxalate
Resins & resinoidsToxic plant resins = phenolic compounds Important naturally occurring phenolic resin in plants Exists as amorphous & brittle solids Insoluble in water, soluble in organic solvents (alcohol,
chloroform & ether)I. TetrahydrocannabinolII. HypericinIII. Urushiol
Tetrahydrocannabinol
• Cannabis sativa (marijuana or hemp)
Hypericin • Hypericum perforatum
Urushiol• Poison ivy• Poison oak• Rhus sp.
CLINICAL & PATHOLOGICAL EFFECTS
• Specific action of toxicantsReceptor mediated, ionic channels, enzyme mediated, carrier molecules mediated events.• Non specific action of toxicantsPhysical toxicants, direct chemical injury, interference with body metabolism, impairment of O2 transport, injury to vascular system, altered Ca++ homeostasis, immunomodulations, carcinogenesis, non-specific action on enzymes & proteins, tissue residual effects.
General Clinical signs affecting systems
1. CNS: ConvulsionCyanide, nitrate, strychnine, OP, Carbamates, Picrotoxin. Coma Bromide, CO, Nicotine, Morphine, ZnP. Ataxia OP, carbamates, Thallium.2. Digestive system:Nausea, vomiting & diarrhoea heavy metals, fluoride, paraffin, muscarine, OP. Constipation Opioids, Oxalate producing plants. Hypersalivation OP &
Carbamates.Dry mouth Atropine, Opioids & Phenothiazines.
3. Respiratory system:Dyspnoea Opioids, OP, cyanide, nitrate & nitrite producing plants, strychnineHyperpnoea aspirin, isoniazid, atropine, nicotine, apomorphine.Slow respiration atropine late stage
4. Skin. Hair & nails:Cyanosis (metHb.) nitrite producing plantsPhotosensitisation Lantana camara, Alopecia alkali sulphide, X-radiation
5. Urogenital tractsUrinary retention atropine, opioids
Micturation & incontenance OP & CarbamatesCrystalluria oxalates, amaranthus.
Poisonous plants • Cyanogenetic plants• Plants producing lathyrism• Plants producing thiamine deficiency• Plants producing Photosensitization• Datura & related plants• Oleander & Cardiotoxic plants.• Plants containing toxic lectins/ castor bean
poisoning.• Ipomoea poisoning• Cotton seed/gossypol poisoning• Nux vomica poisoning.
Cyanogenetic plants• Eucalyptus, kappa/ tapioca, sorgum/corn, linseed cake,
bitter almond.• MOA: HCN + trivalent iron of cytochrome oxidase
inhibits ETC
• Tissue anoxia in brain • Peracute & acute toxicity, chronic toxicity.• restless, laboured & quick breathing, stumbling gait,
tachycardia, salivation, lachrymation, mydriasis, cyanotic mucus membrane & bitter almond smell.
• Sodium nitrite & Sodium thiosulphate.
Cattle & sheep @ 20 mg/kg slow IV followed
by sod. Thiosulphate @ 500 mg/kg slow IV
as 25% soln.
Dogs & cats @ 25 mg/kg slow IV as 1 %
soln. followed by sod. Thiosulphate @ 1.25
g/kg slow IV as 25% soln.
Horses @ 16 mg/kg slow IV as 1 % soln.
followed by sod. Thiosulphate @ 30-40
mg/kg slow IV as 20 % soln.
Plants producing lathyrism
• Legume lathyrus / wildpea / Khesari dal• Osteolathyrism – BAPN (irreversible inhibition
of lysyl oxidae)• Neurolathyrism – ODAP (symmetrical axonal
degeneration)
Osteolathyrism & Neurolathyrism
Plant producing thiamine deficiency• Braken fern/ pteridium aquilinum
• Toxic principles – Thiaminase, aplastic anaemia factor, Ptaquiloside, haematuria factor, Quercetin.
• Cattle: bleeding from body orifices Urogenital, Nostrils, GIT, severe BM depression, thrombocytopenia, HYPHEMA, enzootic haematuria, death due to anaemia.
• Horses: emaciation, lethargy, wt. loss, recumbancy followed by muscular tremors, clonic spasms & Opisthotonus, colic, braken staggers, haemolytic crisis.
Oxalate accumulated plants• Sarcobatus, rheum, beet.• Ruminants/ Cattle • Soluble potassium &
sodium oxalates.• MOA- form complex with
serum Ca++ hypocalcemia muscular weakness, CNS depression, CVS collapse.
Plant producing
photosensitisation• Primary Hypericin, fagopyrin
• Secondary senecio sp. Lantana sp.
Plants producing
allergic stomatitis • Lantana
• Acacia• Dracula stromonium• Jatropa leaves/ cake• Abrus spp
Strychnos nux vomica poisoning• Alkaloid – strychnine & brucine
Treatment of poisoning
• Preventing continuous absorption of toxicant
• Preventing distribution of toxicant to target site
• Increasing threshold level of toxicity• Hastening elimination of absorbed toxicant• Enhancing metabolic conversion of
absorbed toxicant.
Preventing continuous absorption of toxicant
• Gastric lavage• Adsorption theraphy• Purgation/ cathartics• Enema• Cleansing of eyes/ skin/ hairs• Gastrotomy/ rumenotomy• Dilution• Complex formation
Preventing distribution of toxicant to target site
• Ion-trapping• Alternate binding site• Complex formation
Increasing threshold level of toxicity
• Rx for resp. depression• Monitoring cardiac disturbances• Control of shock• Control of acidbase disturbances• Maintenance of uresis• Rx of Hypo/Hyper thermia
Hastening elimination of absorbed toxicant
• Ion-trapping• Dialysis• Diuresis• Specific treatment