-Arunaksha Chakraborty-B.Pharm 3rd Year 6th Sem

Mentor -Ast. Prof. Swarupananda

Mukherjee

GOLD NANOPARTICLES-TARGETED DRUG DELVERY

FOR ANTINEOPLASTIC DRUGS

IntroductionOverview Preventive approachCancer treatmentApplicationsAdvantagesDisadvantagesFutureconclusion

CONTENTSDEAD

TUMOR CELLS

Nanotechnology will change the very foundations of cancer diagnosis, treatment, and prevention.

If we take an imaginative approach. Of course, this is quite logical,

Since everything around us is made up of atomic and molecular matter

All of our problems are ultimately rooted in atomic and molecular arrangements. Nanotechnology has at last provided a way for us to rearrange and restructure matter on an atomic scale, allowing us to reach down to the very roots of any problem

1. INTRODUCTION

Nano Particles

Nanotechnology is the engineering of functional systems at the molecular scale.

Nano refers to the 10-9 power, or one billionth. .For comparison, a human hair is about 100,000 nanometers thick.

The word itself is a combination of nano, from the Greek “nanos” (or Latin “nanus”), meaning “Dwarf”, and the word "Science”.

2. OVERVIEWRelevant Comparisons

Water molecul

eWhite

blood cell Tennis ball

A Gold Nanoparticle

Most animal cells are 10,000 to 20,000 nanometers in diameter.

nanoscale devices (less than 100 nanometers) can enter cells and the organelles inside them to interact with DNA and proteins. Tools developed through nanotechnology may be able to detect disease in a very small amount of cells or tissue. They may also be able to enter and monitor cells within a living body.

Nano particles Are Small Enough to Enter Cells

Cell

White blood cell

Nanodevices

Nanoparticles

Cancer is a class of diseases characterized by out-of-control cell growth. There are over 100 different types of cancer, and each is classified by the type of cell that is initially affected.

Cancer harms the body when damaged cells divide uncontrollably to form lumps or masses of tissue called tumors.

Tumor cells are basically two types. A tumor cell is part of a tissue that is abnormally growing. It may

be either malignant or benign in nature

What is Cancer ???

Liver cancer

Gold Nanoparticles Can Improve Cancer Detection and Diagnosis

NanoBiotechnology Imaging Physical Exam,Symptoms

SYNTHESIS

Oh!! Shit cancer.. I will be

dead soon

Chemo is so easy

Back to

work

Mechanism of action ( NO PHARMACOLOGY)Gold nanoparticles (GNP) are emerging as promising agents for cancer therapy

and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. Due to its small size, high surface area ratio and being chemically inert gold acts as an active vehicle which binds specifically to the tumor cell. The main advantage

of GNPs is that they minimize the toxicity of the anti cancer drugs.

Research studies have sighted that gold nanoparticles produce covalent

bond with the cytotoxic drug and don’t react with any other molecule.

Targeted cell therapy is achieved in GNP drug delivery system and special interaction between light matters at

right wavelength turns gold nanoparticle into precise cancer cell

killers. Infra red light is used to oscillate the gold nanoparticles

attached with the cancer cell and the energy formed due to oscillation as

heat and at sudden temperature increase kills the cancer cell. This

review work displays the applications of gold nanoparticles as targeted drug delivery tools for the cancer therapy.

VARIOUS APPLICATIONS OF GOLD NANOPARTICLES

ADVANTAGESGold nanoparticle is simple for diagnosis.

It is less invasive.

It is provides increased contrast for diagnosis of oral cancer.

It is nontoxic to human beings.

It does not photo bleaching or blinking which is inherent to many other fluorophores.

Reticuloendothelial system gets affected in presence of gold nanoparticle

Bit expensive

THAT’S IT

DISADVANTAGES

“WHEN WORLD SAYS GIVE UP….

TRY WHISPER HOPE ONCE”

Parvesh Sharma, Scott C Brown, NiclasBengtsson, et al. Gold- nanoparticle.

Helcher, H. H.AurumPotabileoder Gold Tinstur; J. HerbordKlossen: Breslau and Leipzig, 1718.

WeiboCai, Ting Gao, Hao Hong, et al. Applications of goldnanoparticles in cancer nanotechnology. Nanotechnology, Science and Applications 2008;1:17-32.

Huang X, El-Sayed IH, Qian W, El-Sayed MA. Cancer cell imaging and photo thermal therapy in the nearinfraredregion by using gold nanorods. J Am ChemSoc 2006;128:2115–20.Gold Nanorod Antennas for Ultra selective Tumor Ablation.

Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000;407:249^57.

RisauW. Angiogenesis and endothelial cell function.Arzneimittelforschung1994;44:1141^6.

REFERENCES