www.emka.fr

Instruments for life science research

cardiorespiratory

neuro

physiologypharmacologytoxicology

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emka TECHNOLOGIES and SCIREQ provide innovative products and services for in vivo and in vitro research for over 20 years.

Our hardware and software are used daily, validated by major pharma companies and CROs and cited in over 2,000 peer-reviewed scientific publications.

A strong partnership dedicated to quality

emka TECHNOLOGIES and SCIREQ have been working hand in hand since 2002. Both organizations share a customer-centric approach and create integrated instruments that combine measurement accuracy and reproducibility with user-friendly software and advanced traceability.

Unparalleled know-how, worldwide support and expertise

With a team of 60 and offices in France, Great-Britain, Spain, Canada, USA, China, Japan, Middle East and a network of distributors, we offer:

» the most complete range of instruments for life science research on the market » a well deserved reputation for fast and reliable support and service.

Meeting the needs and challenges of modern-day research

We are very fast in providing added functionalities as suggested or required by our users. We know this is what you expect. We know this is our proven way to success.

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www.emka.fr

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cardiovascular.emka.fr

telemetry.emka.fr

pulmonary.emka.fr

Hardware product lineTypical applications: » resistance/compliance » cardiorespiratory studies » respiratory mechanics studies » exposure » nebulization » cough/sneeze detection » vital sign monitoring

Typical applications: » CNS studies

(epilepsy, seizure, sleep) » cardiovascular studies » pulmonary studies

Typical applications: » ECG studies (arrhythmia,

heart rate variability etc.) » blood pressure studies » pv loops » thrombosis » hemodynamics

Typical applications: » gastrointestinal dysfunctions » prostate dysfunction » hypertension » diabetes » edema » drug-induced cardiac toxicity » ischemia-reperfusion » mitochondrial function

Software suite Pages p 16-18: » iox2, data acquisition and real-time analysis software » datanalyst, data reduction and reporting software » ecgAUTO, post-processing analysis software » studyDESIGNER, study management software

Pages 4-7: » whole body plethysmograph » double chamber plethysmograph » plethysmograph for anesthetized rodents » flexiVent » ecgTUNNEL » inExpose » nebulizationCONTROLLER » Mass flow controller » PhysioSuite » SomnoSuite

Pages 8-11: » rodentPACK2 » easyMATRIX » easyTEL » emkaPACK4G

Pages 12-13: » pressure and pressure/volume catheters » usbACQ » usbAMP » nibpSNAPSHOT » flowmeters » CODA system

Pages 14-15: » emkaBATH2 tissue bath » emkaBATH4 tissue bath » isolatedHEART system » 4-channel asynchronous stimulator » perfusion system for mesenteric beds

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Respiratory studies

Whole-body plethysmograph for freely moving subjects

» long term monitoring of pulmonary function » mainly used to measure bronchoconstriction » aerosol or gas exposure » no surgery - monitor the same animal day after day » for mice, rats and guinea pigs. On request, larger

plethysmographs can also be manufactured for other animals, such as rabbits, ferrets, dogs, pigs, or primates

Options: » temperature and humidity correction » apnea and cough/sneeze detection pack » tall plethysmograph for behavior studies » tower for swivel/tether system, for rats and guinea pigs, for

simultaneous measurement of non-pulmonary parameters (BP,ECG, SPO2…or blood sampling - drug injections)

» chamber for neonates

Double-chamber plethysmograph for conscious restrained subjects

» measurement of nasal and thoracic flows » can be used in head-out configuration » aerosol or gas exposure » specific airway resistance/compliance measurements » can be combined with pressure signal from telemetry implant to

get real resistance/compliance in conscious restrained subjects » no surgery, no anesthetic

Plethysmograph for anesthetized rodents

» measurements of pulmonary pressure and flow » full pulmonary mechanics (resistance/compliance...) » may be used on ventilated or spontaneously breathing subjects » for mice, rats and guinea pigs » aerosol can be delivered during ventilation » combination with cardiovascular (BP, ECG..) signals and vital

signs monitoring

RIP respiration from belts (for large animals)

» lung volume measurement via respiratory inductive plethysmography (see “telemetry for large animals” section)

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Respiratory mechanics

flexiVent, gold standard for in vivo lung function measurement

The flexiVent is widely regarded as the gold standard for in vivo lung function measurements. It goes beyond traditional resistance and compliance measurements, and captures crucial details about the mechanical properties of conducting airways, terminal airways and parenchyma.

» animals from 3g to 1kg using various module sizes » precise and rapid volume- or pressure-controlled mechanical

ventilation » automatic positive end-expiratory pressure (PEEP) control

Broadest range of measurements in a single platform: » single frequency FOT (resistance/compliance) » broadband FOT (distinguished between airways & tissues

resistance) » pressure-volume loops, forced expired manoeuvres, deep

inflation, delivered dose

System configurations and extensions: » deep inflation for alveolar recruitment before aerosol delivery » Multi-Subject Extension (MSX), designed for lung mechanics

assessment in up to 4 anaesthetized subjects in parallel » FEV extension for Negative Pressure Forced Expiration

(NPFE) in mice and rats » residual volume extension with spirometry measurement :

TLC, RV, FVC... » the ideal tool for obtaining better in vivo thoracic imaging » Aeroneb ultrasonic nebulizer efficiently delivers

bronchoreactive agents and drugs deep into the lungs

flexiWare software:

FlexiWare is a data acquisition software combining a powerful, flexible data flow control engine with a clean, easy-to-use interface. This combination of efficiency and simplicity allows you to operate the flexiVent in an intuitive manner so that you can focus on your results, not on your equipment.

pulmonary.emka.fr www.scireq.com

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Cardiorespiratory studies

ecgTUNNEL for noninvasive cardiorespiratory studies

» gets 6-lead ECG signal in a few seconds with 4 electrode pads » optional respiration measurement (like in whole body

pethysmograph) » designed for conscious restrained mice and rats » each model accommodates neonate to adult subjects

(interchangeable tunnels) » noninvasive - no anesthetic and no surgery » quick and easy setup » rapid adaptation » plug-&-play data acquisition (integrated amplifier, USB link to

computer)

Plethysmograph and implanted telemetry

The combination of plethysmography with implanted telemetry opens up new possibilities, for example:

» pulmonary, blood pressure and ECG recording in a whole-body plethysmograph (the animal has an implant measuring pressure and ECG).

» direct resistance/compliance measurements in non-sedated animals, combining the pulmonary pressure signal coming from a implant with flow signal a from a head-out plethysmograph.

Mass flow controller

» deliver a specific gas mixture to animal chamber (plethysmograph for example)

» ideal for hypoxia, hyperoxia, hypercapnia evaluation » iox2 software performs the aquisition and controls the mass flow

controllers » modify the composition of the gas mixture in real time, directly from

iox2 software

PhysioSuite, vital sign monitoring

» pulse oximeter & heart rate monitoring » temperature monitoring and homeothermic control » End-Tidal CO2 Monitoring » automatic ventilation

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Exposure systems

inExpose, benchtop inhalation exposure to cigarette smoke and toxins

» controlled delivery of multiple gas/toxin mixtures » nose-only and whole-body exposure » unique soft restrainer for mouse minimize skin exposure and

overheating » low internal volume: unintentional diluation of precious

compounds is reduced and aerosol rain-out is captured to allow users to re-use their costly compound

» single cigarette chamber or cigarette smoking robot (CSR) for mice and rats cigarette smoke exposure: - computer-controlled & programmable rotary cigarette smoker - up to 24 cigarettes smoked in any possible parallel/sequential combination, with programmable puffing profiles and automatic lighting & ejection

» all functionality is controlled and managed by flexiWare software package which controls the acquiring, displaying and archiving of data while monitoring vital signs and exposure in real-time.

Applications:

» respiratory disease model generation » inhalation toxicology » tobacco studies » e-cigarettes and vaping » allergen and ambient air pollutants » inhaled therapeutics and respiratory drugs » nanomaterial exposure

SomnoSuite, small animal anesthesia system

» for mice and rats » precision low-dose delivery system uses less than 1cc of isoflurane/hr » digital automatic ventilator, both volume & pressure controlled » Pulse oximeter/heart rate monitor

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“Ideal alternative to swivels or implants!”

LAN

Telemetry for neuro studies

rodentPACK2 for cardio or neuro studies

Head mounted or backpack miniature telemetry transmitter for use in animals > 50 g:rodentPACK2 enables the acquisition of EEG and other biopotential signals, as well as temperature and activity/positional data - applications are varied, e.g. sleep and epilepsy studies, ECG recording.

9 configurable signals are acquired: » 4 biopotentials (EEG, ECG, EMG), sampled at up to 1000Hz » x/y/z accelerations sampled at 50Hz » global acceleration (computed from 3 axes), for activity assessment » core temperature

Compact, light and powerful: » transmitter has a 22mm diameter and weighs 4.4g with batteries » transmission range up to 5 m » 150 hours of continuous recording before replacing batteries » excellent noise-free EEG signal » no refurbishment, batteries cost less than 2$/recording » same transmitter may be used on any implanted animal » x/y/z acceleration signals allow for postural information » total acceleration useful for validating events on EEG/EMG traces » rapid acclimation: rats are not restrained in their activities » animal is freely moving: ideal alternative to tethered system » group housing with multiple animals in same cage » up to 32 animals in same room with no required shielding

rodentPACK2 consists of:

» a skull connector permanently implanted » a transmitter, connected to skull implant only during recordings » a receiver for 4 animals

Smart solution for noninvasive ECG:

» transmitter, fitted with miniature ECG cables and skin electrodes, can be housed in pocket of custom design jacket

CNS analysis with ecgAUTO software

» generatew FFT power spectrums with user defined frequency bands » automated sleep scoring module differentiates between four sleep

stages and calculates global sleep scores » automatic seizures detection is performed using combined analysis

of various parameters

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“Acquire simultaneously synchronized signals from up to 16 impants and 8 analog inputs”

telemetry.emka.fr

Telemetry studies

easyMATRIX seamless link from telemetry implants to emka TECHNOLOGIES software suite

» reads signal from easyTEL implants » reads signal from all DSI™ implants, including recent HD models » only requires connection to existing receivers and to a computer (USB). » records calibrated data in iox2, no need of OpenART™ or acquisition

card in computer » contains its own ambient pressure transducer » up to 16 implant receivers and 8 analog inputs connect to a single

easyMATRIX

» handles cases with 1, 2 or 4 receivers used for each subject » up to 4 easyMATRIX can be connected to a single computer

A unique acquisition platform with accurate synchronization of signals from different sources:

» perfect synchronization of all signals from receivers or analog inputs: combine pleural pressure from implant and respiratory flow from head-out plethysmography for precise resistance & compliance measurement

easyTEL implantable telemetry for rodents

» measures 1 biopotential, temperature and activity » available in two sizes, for mice or rodents >100g » for freely moving rodents » more than 6 months of continuous recording : implant can be used

and re-implanted as long as battery lasts » fully compatible with DSI™ system

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Telemetry for large animals

emkaPACK4G for cardio & respiratory studies on large animals (dogs, primates, pigs)

17 signals produced simultaneously: » 9 lead ECG » 2 respiration belts signals » posture and activity (3 axis + total acceleration) » temperature » blood pressure from:

- noninvasive oscillometric cuff (NIBP) - semi invasive vascular access port (VAP)

Flexible: » noninvasive » only 1 receiver for 16 animals » only 1 Ethernet cable per receiver » 32 to 48 subjects per room, group or single housed » information on lost electrode & low battery level » 10m transmission range » 48 to 72 hours on same batteries

emkaPACK4G takes full advantage of emka TECHNOLOGIES software suite: » full range of on-line and off-line signal analyzers » gold standard for ECG analysis (any species, any lead) » easy & seamless calibration of all signals including respiration belts » synchronized video » GLP tools, audit trail and electronic signature » global study data organization and management

emkaPACK4G transmitter

emkaPACK4G receiver

network

Specific jacket and t-shirts design

» canine, primate, swine and sheep lycra/spandex undershirt and mesh outer jacket

» undershirt is a tight fitting spandex garment that closes and adjusts by means of Velcro fasteners: - a series of external belt loops allow for the best positioning of the two respiratory belts - the ECG leads are held in place by the undershirt

» ¾ length or full lenght jackets available with a number of custom features, depending on emkaPACK4G options

» the transmitter is located in a custom pocket on the back of the jacket

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bptVAP vascular access port blood pressure module

» easy connection to implanted arterial VAP » no transducer drift, easy calibration » up to 2 measurement points per animal

RIP respiration from belts

» lung volume measurement via respiratory inductive plethysmography » thoracic and/or abdominal belts fully adjustable and directly

connected to emkaPACK4G transmitter » transmitter is housed into a jacket worn by the animal » respiration flow is derived from lung volume, all standard pulmonary

parameters & phase shift computation for bronchoconstriction assessment

ecgAUTO RIP analyzer provides absolute values and parameters linked to phase shift between the thoracic and abdominal belts.

Temperature option

» skin temperature from thermistor » automated onset of fever detection with iox2 software

Telemetry for large animals

NIBP oscillometric blood pressure module

Reliable NIBP, not a black box: » proven and validated noninvasive oscillometric cuff method » proprietary software for analysis and control » 60 to 90% of cycles provide reliable data » automated rejection of unstable cycles » with the ecgAUTO software NIBP module, you can see the recorded

data, see how they were processed, analyzed and invalidate or edit results

40°

37°

32°

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Cardiovascular studies

Pressure and pressure/volume catheters for small and large animals

Full range of hardware and software equipements to perfom pressure or pressure/volume analysis using conductance or admittance devices.

iox2 software monitors blood pressure and performs in-depth PV loop analysis from Mikrotip catheters. » mikro-tip pressure catheter from 1 F to 7 F (mouse to large animals) » single and multiple pressure and volume measurement » generate, enter or re-use existing parallel conductance correction » generate or enter alpha correction factor

The PV loops analyzer generates several parameters including: » End-Systolic Pressure-Volume Relationship (ESPVR) » End-Diastolic Pressure-Volume Relationship (EDPVR) » preload recruitable stroke work relationship (PRSW) » arterial elastance (Ea) » stroke work

Multi-purpose acquisition & amplification

» plug-&-play data acquisition solution, designed for direct USB link to computer running iox2 acquisition software

» well suited for a large variety of preclinical experiments: can be used with isometric transducers for tissue contraction studies, blood pressure transducers, differential air pressure transducers, multi-lead ECG, …

» ideal for medium size setups & for systems needing to be moved » adapted to swap between several computers (incl. laptops) » no external settings: all changes in settings are software driven and

fully logged » usbACQ is designed to acquire any amplified analog signals. » usbAMP is designed to acquire and amplify: - biopotential signals (multi-lead or single-lead ECG) - signals from strain gauge transducers (force, pressure ...)

nibpSNAPSHOT, for large animals

Noninvasively measures oscillometric blood pressure (NIBP) and 7-lead ECG:

» 60 to 90% of cycles provide reliable NIBP data - automated rejection of unstable cycles

» place the cuff around the limb and start the inflation/deflation cycle » immediately see both the signal, and results to assess their quality » immediately trigger another measurement cycle or adjust inflation

pressure and deflation speed“Ideal for Toxicology center

using large animals”

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Cardiovascular studies

Heart Rate Variability

The HRV add-on module for ecgAUTO software is a powerful tool designed for heart rate variability analysis.

It analyzes beat-to-beat (RR) interval variation from ECG recordings and automatically produces multi-epoch analysis, including parameters such as:

» mean interval, SDNN, SDANN, RMSSD, NNnn, pNNnn » triangular index » Poincarré plotting

It also produces full Fourier analysis.

Flowmeters - Gold Standard

To perform acute or chronic flow measurement on blood vessels or perfusion tubings, combine Transonic transit-time technology flowmeters and dedicated iox2 software analyzers.

An extensive range of probes is available to suit your needs.

You can measure volume flow through arteries, veins and ducts, of different species and of diameter 0.25 mm and upwards. Tubing and perfusion applications are also possible.

A wide range of Laser Doppler Probes is available to perform real-time continuous microvascular perfusion measurements in approximately 1 mm3 of tissue (acute use or chronic application).

All models provide calibrated analog signals (in flow units) that can be directly connected to any type of data acquisition systems, such as iox2.

CODATM for rodents

» Noninvasive blood pressure from mice and rats » 6 parameters measured simultaneously: systolic, diastolic, mean BP,

heart rate, tail blood volume & blood flow » up to 8 rodents on the same system » clinically validated Volume Pressure Recording (VPR) » dark-skinned mice (C57BL/6) without difficulty » awake or anesthetized animals with equal accuracy & reliability » MRI compatibility » clear acrylic holders provide unrestricted breathing and allow

complete visibility to the researcher » seven holder sizes available » tail is unrestrained to allow for regular tail movement

cardiovascular.emka.fr

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“emkaBATH4, fully automated 4-channel system”

Isolated tissue studies

(aorta, trachea, papillary muscles, microvessels etc.)

» compact & integrated benchtop setups » bath temperature display and control » physiological liquid heated in-line - no need of extra water heater » available with 2 models of isometric transducers (possible adaptation

of isotonic transducers) » can be used as standalone setup or connected to iox2 software

emkaBATH2, compact and cost-effective

» 1 or 2-baths » fits on lab bench » simple to set up, run and clean » automatic bath filling (accessible from protocol in iox2) » manual bath emptying and tissue tension » closed triangle and C shape hooks available

emkaBATH4 , 2-in-1 tissue bath system

» up to 4 baths (5, 10 or 20 ml) » for isolated tissue & microvessel studies » automated bath filling/emptying/renewal/overflow » automated motorized tissue tensioning and lengthening » electrodes for contact or field stimulation » open or closed triangle, L and C shape hooks available » automated software control from iox2 and direct front panel control

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“Rapid switch from Langendorff to working heart mode”

Isolated heart studies

Langendorff and Working Heart system

» compact setup for isolated perfused hearts » especially designed for mice and rats hearts - adaptable to rabbits and

guinea pigs » perfusion as constant flow or constant pressure modes in Langendorff

model » perfusion as Working Heart setup » up to 3 different perfusion liquids » LVP, ECG, MAP, VAP and temperature measurements » electrical stimulation » very low dead volume and perfect temperature regulation

Stimulation and perfusion

4-channel asynchronous stimulator

» constant current or a voltage on each of up to 4 channels independently » can be operated manually or from iox2 acquisition software » wide range of stimulation protocols can be created and automatically

executed » all stimulation parameters are adjustable (main frequency, stimulation in

current or voltage, pulse amplitude, pulse width, pulse polarity, type of stimulation, duration of the train or pulse number in the train)

Perfusion system for mesenteric beds

» 1 to 4 independent baths » perfusion flow from 5 to 20 ml/min » easy-to-manipulate steel organ beds » adjustable organ bed heights, bath volume and carbogen supply » electrical stimulation possible through stainless steel beds » suitable for any experimental protocol (constant flow, different protocols

for each bath, simultaneous or delayed perfusion…)

isolated-organ.emka.fr

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Software suite

iox2, data acquisition and real time analysis

Aquisition & analysis: » up to 250 inputs (10Hz to 100kHz) » real-time signal analysis and display, trend graphs » data tables, event logbook » protocols as experimental guideline or automation » external device control » record of DSI™ and easyTEL telemetry implants, through easyMATRIX

» multiple acquisition performed through AD board, USB, ethernet » synchronized video recording and review

Specific analyzers for real time processing of: » blood pressure & flow, pulse pressure, left ventricular pressure » ECG, EEG, EMG » pressure/volume loops, pressure/distance » ventricular wall thickness or segment length » respiratory flow, penh, cough and apnea detection » lung resistance/compliance, double chamber plethysmograph » slow & rhythmic contractile tissue » action potentials » cystometry » power spectrum analysis and also nerve, etc. » temperature, onset of fever, acceleration.

datanalyst, data post-processing software

datanalyst processes calculated and statistical parameters from files generated by iox2. Data from an unlimited number of experiments is pooled together. Fast and versatile data extraction is performed automatically.

Data reduction: » pools subjects into single study » full experiment review » identifies protocol events » exclusion of artefacts

Extraction of key data: » edits event markers » automated extraction using protocols » finds min, max, area, kinetics... » performs statistics » computes EC50 » results as graphs & tables

Reporting: » customized export templates » print reports from datanalyst » export reports as text files

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Software suite

ecgAUTO, advanced post-processing analysis

ecgAUTO performs fast, reliable, in-depth ECG and non-ECG analysis. It analyzes normal or abnormal ECG complexes, from any species on any lead, using shape recognition techniques.

This techique uses a library of reference waveforms, built by the user for his specific needs.

Analysis is carried out on segments of data («steps») defined by protocol linked to original experimental markers.

Powerful, fast, reliable ECG analysis:

» beat-by-beat calculation of intervals (RR, QRS, QT...), amplitude, elevation etc.

» any species, any leads » detection of arrhythmia and abnormal events » inter- and multi-lead processing » automated multi-file analysis » predefined/customizable QTc formulas

Comprehensive review features: » full list of detected beats, trend graphs » average beats and statistical values per step » holter-type calibrated print-outs » synchronized video review

Advanced features: » subject specific QT correction » HRV (heart rate variability) analysis » isolated p-wave detection » reads non emka data file formats, including DSI™ telemetry data files

Non-ECG data: » blood pressure/flow, Left Ventricular Pressure » monophasic action potential » EEG/EMG including FFT, sleep scoring and epilepsy detection » respiratory data, NIBP

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Service packages

On-site demonstration, installation, training & support

» live demonstration in customer laboratory » system installation and training sessions » fast and reliable support & maintenance contracts » on-site system validation

Software suite

studyDESIGNER, to plan and organize your studies

studyDESIGNER is a high level tool to organize and automate data recording, analysis, control and archiving on large toxicology or safety pharmacology studies.

During recording sessions studyDESIGNER automatically drives iox2 and ecgAUTO software to record and analyze data and send calculated parameters to its data base.

Designed to make your studies easier and safer:

» defines study structure and subjects details, pre-test and treatment groups, data collection and analysis settings

» acquires data on subjects planned for current sessions or automatically according to predefined protocol

» analyses data automatically on all recordings or according to subject or phase

» reviews subject or global results » archives results using customized database queries or through

secured link to your LIMS or as customized reports

GLP modules

GLP modules of iox2, ecgAUTO, datanalyst and studyDESIGNER

include all features for 21 cfr part 11 compliance:

» data integrity and accountability » electronic signature » audit trail to record all user operations in a non editable file » audit viewer for rapid review of audit trail » user management for user-specific access to software and functions » study management, to tag an identifier on all files used or produced

within a given study

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“When compared to telemetry, the restrained ecg monitoring method

[ecgTUNNEL] shows a very good yield”

Institut de Myologie (INSERM U582), Pitié-Salpêtrière Hospital, Paris

Mongue-Din H et al (2007). Non-invasive restrained ECG recording in conscious small rodents: a new tool for

cardiac electrical activity investigation.

“Since settings and analysis can be standardized with commercial software, we chose ECG-auto by EMKA Technology [...]. This software performs fast, reliable, field-tested, in-depth ECG analysis with full user control. It allows fast Fourier transform (FFT)-based time-domain

analysis and frequency-domain study with beat-by-beat control and review.”Laboratory of Cardiac and Vascular Cell Physiology (CNRS Unit “UMR 6542”) ,

François-Rabelais University, Tours, France

Thireau J et al (2008). Heart rate variability in mice: a theoretical and practical guide.

“The emkaPACK4G wireless telemetry system can be used as an accurate, effective, and non

invasive tool to measure rumen motility and obtain detailed measurements of ruminal

contractions in ruminally cannulated animals.”University of Kentucky

Egert et al (2014). Development of a methodology to measure the effect of ergot alkaloids on forestomach motility using real-time

wireless telemetry.

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north america

emka TECHNOLOGIES Inc 307 Annandale Road, suite 203 Falls Church, VA 22042 – USA tel: +1 (703) 237-9001fax: +1 (703) 237-9006emkatech@emkatech.comwww.emkatech.com

SCIREQ 6600 St-Urbain, Suite 300AMontréal, QC H2S 3G8 – Canadatel: +1 (514) 286-1429toll free: +1 (877) 572-4737fax: +1 (514) 286-1427sales@scireq.comwww.scireq.com

worldwide distributionTo find your local distributor, in Israel, India, Korea, Taiwan, Brasil etc., consult our website on www.emka.fr

middle-east

emka TECHNOLOGIES SASRiyadh, PO Box 261632 Riyadh 11342Kingdom of Saudi Arabia

emka@dce-ksa.comwww.emka.fr

europe

emka TECHNOLOGIES SAS59, bd. Général Martial Valin75015 Paris – France tel: +33 (0)1 40 60 76 00 fax: +33 (0)1 40 60 65 55emka@emka.frwww.emka.fr

china

emka BIOTECH Beijing Co Ltd Rm 935 Laho Studio, No.15-A1 East Jianguo Road Chaoyang District, Beijing 100024 – Chinatel: +86-(0)10-85376382 or 400-661-8288fax: +86-(0)10-85376384info@bjgyd.com / www.bjgyd.com emka BIOTECH Shanghai Co LtdRm 710 Building 3, No.2288 Zhuchongzhi Road, Pudong District Shanghai 201203 – Chinatel: +86-21-61097518 fax: +86-21-61097518 emka BIOTECH Hong Kong Co Ltd Rms 1318-20, Hollywood Plaza, 610 Nathan Road, Monkok, Kowloon, HK – China tel: 00852-35000568  or 00852-27108200-3296 fax: 00852-29978306 info@bjgyd.com / www.emkabiotech.cn

japan

emka TECHNOLOGIES Japan Urban Ace Sannomiya Building 10F4-1-22, Onoe-dori, Chuou-kuKobe 651-0088 – Japantel: +81 (0)50 5830-9882info@emkatech.jp www.emkatech.jp

emka TECHNOLOGIES & SCIREQ

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