Presented by : Prince

Obama’s Precision Medicine Initiative• Medical treatments have been designed for “average patients”

• Precision Medicine is an innovative approach that takes into account individual differences in people’s genes, environment, and lifestyles

•As a result of this “one-size-fits-all” approach, treatments are not successful for all

What is Obesity?Abnormal accumulation of body fat

Just measure your weight in Kilograms (kg) and your height in meters (m), and then use this formula

Are you Obese?

Pathophysiology of Obesity

Pre-opiomelanocortin

*MSH – Melanocyte Stimulating Hormone

*

Melanocortin4 Receptor

What causes Obesity? Genetics

Overeating

Physical inactivity

Medication

Diseases

Lack of sleep

Social issues

Genes associated with

obesity• Leptin

•MC4R (Melanocortin 4 receptor)

• PCK1 (Phosphoenol pyruvate carboxylase 1)

• POMC ( Pre-opiomelanocortin)

Drugs Mechanism of Action

Adverse Drug Reaction

Orlistat Inhibit pancreatic

lipase

Gastrointestinal side effects

Sibutramine Inhibit norepinephrine & Serotonin

Heart attack

Rimonabant Cannabinoid 1 receptor

antagonist___

Metformin Decrease production of glucose from

pancreas

Impaired Renal

functions

What are the complications of obesity?

High blood pressure

Heart disease

Gallbladder disease

Osteoarthritis

High cholesterol and triglycerides

Obesity Treatment Pyramid