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In Memory ofTony J. Harmar FRSE
28th Nov 1951 – 10th APRIL 2014
2014 JR Vane Medal lecture
Presented by Michael Spedding
British Pharmacological Society's Fellows' Reception
2
Nobel Prize 1982
Knighted 1984
700 Publications, 20 books, innumerable awards
Vane biocascade assay technique
Mechanism of action of aspirinCycoloxygenases, prostaglandins,Thromboxanes
R&D Director of Wellcome Foundation
Founded William Harvey Research Institute
3
Circadian rhythm of biological parameters
MT
melatonin
Suprachiasmatic
nucleus
Light
Pineal
gland
Melatonin activity in the central nervous system
Chronobiotic
effectMT1 MT2
Depression ?
Neuronal Plasticity and Chronobiology are crucially important : new antidepressant mechanisms
6
7
VPAC2 PER1 and PER2
8
9
10
11
12
13
Physiological definition of circadian rhythms – food versus light
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Immune-Circadian Interactions
In memory of…our database chairman
Anthony (Tony) John Harmar, FRSE
28 November 1951 – 10 April 2014
17
NC-IUPHAR membershipIUPHAR/BPS Guidetopharmacology
• The main committee
• NC-IUPHAR meetings• Twice a year (Spring and Autumn), in Edinburgh and Paris; • Attended by members of the core committee and invited guests relevant to topics on the
agenda (e.g. corresponding members).• Members welcome.
Chair
Michael Spedding, France
Vice Chairs
Antony Harmar – Database (Jamie Davies)
Anthony Davenport, UK - Chairman Evolving
Pharmacology Group
Rick Neubig, USA - GPCRs
Eliot Ohlstein, USA - Editor
Members
Stephen Alexander, UK
Thomas Bonner, USA
William Catterall, USA
Arthur Christopoulos, Australia
Sir Colin Dollery, UK
John Cidlowski, USA
Doriano Fabbro, Switzerland
Kozo Kaibuchi, Japan
Yoshikatsu Kanai, Japan
Alex Phipps, UK
John Peters, UK
Jean-Philippe Pin, France
Ex Officio
Patrick du Souich, Canada (Clinical) - IUPHAR President
Sam Enna, USA - IUPHAR Secretary-General
Urs Ruegg, Switzerland - IUPHAR Treasurer
Simon Maxwell, UK - Educational Site Project Leader
Jamie Davies, UK - Database Principal Investigator
Joanna Sharman, UK - Database Developer
Adam Pawson, UK - Senior Database Curator
Helen Benson, UK - Database Curator
Elena Faccenda, UK - Database Curator
Christopher Southan, Sweden - Chemical Curator
Veronika Divincova, UK - Project Administrator
Matt Wright, UK - representing HGNC
Past Chairs (ex officio)
Paul Vanhoutte, China
Robert Ruffolo, USA
Some NC-IUPHAR achievements
• Human and organisational:1. Celebrate the life and work of Tony Harmar – set up database at
Edinburgh.
2. IUPHAR/BPS Guide to PHARMACOLOGY database based in Edinburgh, with joint funding from IUPHAR and The British Pharmacological Society (BPS)
3. A federation of >80 drug target subcommittees, representing ~800 expert pharmacologists worldwide, allowing an independent academic/industrial expert-driven system of data collation and giving recommendations on key pharmacological interactions.
4. A unique human organisation allowing experts to validate their own areas, with authority, and to have their propositions published with high impact (good for their young co-authors) and freely available in the database.
5. Sometimes the human/scientific aspects can lead to real controversy !
Some NC-IUPHAR achievements
• Nomenclature:1. Cumulative H-Index for NC-IUPHAR is 72.
2. The 5-HT receptor nomenclature paper has been cited 2878 times, prostanoid receptor nomenclature 1721, adenosine receptors 2017, chemokine receptors 2022, cannabinoid receptors 696, muscarinic receptors 1226.
3. The nomenclature for voltage-gated ion channels was entirely rationalised by NC-IUPHAR.
4. Reorganisation of ligand-gated ion channel receptor nomenclature.
5. A potential tsunami of spurious GPCR heterodimers (caused by overexpression in artificial systems) was stopped by recommending rigorous criteria.
6. The recent (non-contentious) classification of transporters, and the complete pharmacology of kinases in guidetopharmacology have been achieved in very short periods of time (~1 year).
Tony’s last joke ?
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My reply….
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IUPHAR/BPS Guidetopharmacology
How can we Continue and Improve on Tony’s legacy ?
How can we engage fellows more ?