This presentation was given at the symposium: Genomics for Health and Environment in Nijmegen on Oct 30, 2014 http://www.studiegids.science.ru.nl/2014/science/prospectus/biology_bachelor/course/34732/ The presentation introduces Open Science and Open Access Publishing and discusses these concepts in relation to (human) genomics. The discussion includes a presentation of the concept behind http://repositive.io, the social enterprise software platform which was spun out of the DNAdigest research activities. As a special edition to the students in the audience who are curious about their future scientific career, I included a couple of slides about my move from academic research to being a social entrepreneur. DNAdigest works to promote and enable easier and more efficient sharing of genomics data for research. We educate and engage the community about the hurdles and dilemmas for data sharing as faced from the perspective of stakeholders in academia, industry and patient communities. As part of our work we are working with our community and supporters to prototype new mechanisms and concepts for data sharing and data access. Please visit our website to learn more about our activities and events: http://DNAdigest.org Follow us on twitter: @DNAdigest
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1. The need to redefine genomic datasharing moving towards Open
ScienceGenomics for Health and Environment Symposium 2014 By Fiona
Nielsen
2. Why is data sharing
important?https://www.flickr.com/photos/ntnumedicine/8056093615 3.
My motherCC-BY Fiona Nielsen 4. Mabelhttp://www.rameelinlarson.com/
5. The long road to resultsRaw readsRead QCVariant
callingAnalysis-readyreadsVariantAnnotation
GenotypeAnalysis-readyvariantsRefinement Raw IndelsRaw SVsRaw
SNPsMappingExternal DataCC-BY DNAdigest 6. Where is the
data?~400khumangenomessequenced~5kavailable2006 2007 2008 2009 2010
2011 2012 2013 2014 2015 7. The move towards Open
Sciencehttps://www.flickr.com/photos/f4/12652885873 8.
https://www.flickr.com/photos/medmss/7166591489 9. Modern Science
Publications arebuilding blocks..standing onthe shouldersof
giantshttp://en.wikipedia.org/wiki/Philosophi%C3%A6_Naturalis_Principia_Mathematica#mediaviewer/File:NewtonsPrincipia.jpg
10. Open Access publishingSee also:
http://www.slideshare.net/jelena121/open-access-talkhttp://www.opensocietyfoundations.org/explainers/what-open-access
11. More than OA publishing Transparency Availability Accessibility
Reusability
Collaborationhttp://commons.wikimedia.org/wiki/File:Open_Science_-_Prinzipien.png
12. How to do Open Science?Old fashioned research: Work, finish,
publishAim for reproducibility: Work, finish, publish, release data
+ methodsCollaborate and share for maximum impact: Work, release,
finish, publishSee
also:http://www.slideshare.net/christianheise/gfm-open-whaaaaaaat102013bmch-27451852
13. Publish everythingCC-BY Fiona Nielsen 14. Share early Share
notes, results Use Figshare Blog about your work Preprints (arXiv,
PeerJ) Acknowledge
sourceshttps://www.flickr.com/photos/edmontonliveallyear/8433538606/
15. Publish Open Access 16. But Open Science in genomics? Consider
sensitive data Ensure consent is followed Publish metadataWhy? 17.
Make your data discoverable Ensure consent is followed Publish
metadata Make your data discoverableCC-BY Fiona Nielsen 18. What
else can we do?Collaborative events + Communication + Research 19.
We asked researchersResearchers spend months tofind and access
genomic data,and often choose to not accessdata at allT. A. van
Schaik et alThe need to redefine genomicdata sharing: a focus on
dataaccessibility, Applied &Translational Genomics,
201410.1016/j.atg.2014.09.013 20. They told us their
frustrationsSearchingFilteringRegisteringAccessing 21. How to make
it a positive experience?CC-BY DNAdigest 22. Repositive.ioDiscover
and filter Register metadataCollaborate Share securelyYou can sign
up for beta testing: http://repositive.io 23.
Repositive.iohttp://www.rameelinlarson.com/You can sign up for beta
testing: http://repositive.io 24.
Q&Ahttp://en.wikipedia.org/wiki/Karyotype#mediaviewer/File:Spectralkaryotype98-300.jpgVisit
us at DNAdigest.org + sign up for our newsletter+ follow us on
twitter @dnadigest 25. An odd career
path?https://www.flickr.com/photos/kkoshy/4334413228/ 26. Where did
that idea come
from?https://www.flickr.com/photos/blackzack00/10205948476/ 27.
Life as an
entrepreneurhttps://www.flickr.com/photos/matthewpaulson/7185380311/ConsultingFundraisingMarketingBrandingPublic
EngagementFinancial forecastsPlanningSoftware
developmentScienceLong daysLittle financial returnBig
satisfactionQuestions? I would love to hear from you ,drop me a
line at [email protected] 28. Thanks!Visit us at DNAdigest.org +
sign up for our newsletter+ follow us on twitter @dnadigest
