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TRYPANOSOMA BRUCEI
RHODESIENSE
Prepared by:
NOE P. MENDEZCENTRAL MINDANAO UNIVERSITY (CMU)
Kingdom: Protista
Subkingdom: Protozoa
Phylum: Sarcomastigophora
Subphylum: Mastigophora
Class: Zoomastigophora
Order: Kinetoplatida
Family: Trypanomatidae
Genus: Trypanosoma
Species: T. brucei
Subspecies: T. b. rhodesiense
2 Interchangeable Form:
Trypanomastigote
Epimastigote
Form:
Amastigotes
Promastigote
Epimastigote
Trypanomastigote
Metacyclic Trypanosome
Kinetoplast (K)
Axoneme (A)Nucleus
(N)
Volution
Granules (VG) Flagellum (F)K A
N
Flagellar pocket (FP)
Amastigote
Promastigote
AKN
Posterior End
Undulating membrane (UM)
F
AK
N
F
UM
Epimastigote
Trypanomastigote & Metecyclic Mastigote
East African Trypanosomiasis (Sleeping Sickness)
Glossina morsitans (Tsetse fly)
Pathogenesis and Clinical Picture
Trypanosoma Chancre
Via:
Lymphatic
Winterbottom’s Sign
Blood Stream
Headache, fever, muscle and joint pain,
irregular erythematous rash, and
hypoplastic anaemia
Invasion of CNS
Sever headache, mental apathy, slow
speech, deep sleep, coma and death
Progressive disease lead to C.N.S. manifestations:
Insomnia
Mood Changes
(Dullness/Apathy)
Motor and Sensory Disorders
(Hypersthesia/Slurred Speech/Abnormal Gait)
Convulsion
Epilepsy
Terminal Stage:
Permanent Sleep
Secondary Bacterial Infection
Coma & death
Clinical Picture
Trypanosoma Chancre
Winterbottom Sign
Epilpsy
Convulsion
Clinical Picture
Demonstration of Trypanosomes
Microscopic Examination
Culture on Suitable Medium
Animal Inoculation
Microscopic Examination
Animal Inoculation
C.S.F.
DEMONSTRATION OF TRYPANOSOME
Clinical Picture
Demonstration of Trypanosomes
Microscopic Examination
Culture on Suitable Medium
Animal Inoculation
Serological Test
Early Stage
Pentaminidine or Suramin
Late Stage
Tryparsamide
Both Early and Late Stage
Eflornithine (DMFO) Ornidyl
Treatment of Patient
Control of Vectors
Pentamidine as prophylactic drug
ENDOF
REPORT
QUESTIONS?
