Biositemaps: A Framework for Biomedical Resource Discovery Patricia L. Whetzel, PhD1, Charles D. Borromeo2, Harpreet Singh, MS2, Jessica D. Tenenbaum, PhD3, Nancy B. Whelan2, Brian Athey, PhD4, Michael J. Becich, MD,

PhD2, Mark A. Musen, MD, PhD1 and the Biositemaps Consortium1Stanford University, Stanford, CA; 2University of Pittsburgh, Pittsburgh, PA, 3Duke University, Durham, NC, 4University of Michigan, Ann Arbor, MI

Abstract

Biositemaps is a mechanism for researchers to openly broadcast and retrieve metadata about biomedical resources. The architecture includes the Information Model and Biomedical Resource Ontology. Biositemaps files are created with the Biositemaps Editor and searched using the Resource Discovery System. To date, the system includes over 1,400 resources from 6 NIH-funded research programs. Future use by other groups will lead to more effective resource discovery and sharing across NIH extra- and intramural program.

Funding Provided by

Clinical and Translational Science Awards • Pittsburgh, 3UL1RR024153-03S1• Duke, 5UL1RR024128-03S1

National Center for Biomedical Computing • National Center for Integrative Biomedical Informatics, 3U54DA021519-04S1• National Center for Biomedical Ontology, 3U54HG004028-04S1

Specific aims

1) Creating an inventory of software, material, funding, service, training, and people resources2) Developing an informatics infrastructure3) Publishing the resource inventory to enable a federated, web-accessible catalog of resources that enable clinical and translational research

Future Goals

1) Accelerated development of Biositemaps across NCBCs, CTSAs and other applicable NIH-funded organizations2) Promotion and outreach of this information framework, using web and print-based media, web-based seminars and presentations, and participation in national meetings3) Continued harmonization of BRO and NIFSTD for common resource descriptors4) Further alignment of the Biositemaps Information model with eagle-i informationmodel

http://biositemaps.ncbcs.org/rds/index.html

Biositemaps Editor

Biomedical Resource Ontology

Biositemaps

• Machine-readable resource associated with a website • Resources are described in terms of an information model • Supported by the Biomedical Resource Ontology • Can be discovered by search engines such as Google, obviating the need for centralized management

Notable Accomplishments

1) A standards-based informatics infrastructure that includes development of a biomedical resource inventory2) Development of the Biomedical Resource Ontology (BRO) 3) Harmonizing BRO and the Neuroscience Information Framework Standard ontology(NIFSTD)4) Mapping the Biositemaps Information Model with the eagle-i Information Model

www.ctsaweb.org www.ncbcs.org

Who Is Involved?

Biositemaps Information Model

Required Properties• Resource Name• Organization • Research Program• Description• Resource Type • URL• Contact Person • Biositemap Author

Additional Properties• Related Areas of Research• Related Activities• Publication Identifier

Ontology and Information Model drive the Biositemaps Editor

Resource Statistics

• Over 1,400 resources collected• Includes resources from a variety of research programs: - CTSAs – 840 - NITRIC – 253 - NCBCs – 229 - Cardiovascular Research Grid – 11 - System Biology institutes – 64 • Viewed by > 1,600 visitors from the US, Spain, Canada, Germany, China, UK, France, Italy, India