Centre d’innovation des technologies de la santé HES-SO Valais-Wallis

HES-SO Valais-Wallis Page 1

Centre d’innovation des technologies de la sante

HES-SO Valais Wallis Un support pour les decisions

liées à la santé

Prof. Dr. Michael Schumacher & Prof. Dr. Marc Pfeifer 2ème journée valaisanne de recherche translationnelle en réadaptation, Sion, 3.3.2014


Health Technology Innovation Center (HTIC)

•  Systems Engineering Institute: Prof. Martial Geiser & Prof. Pierre Roduit

•  Institute of Life Technologies: Prof. Marc Pfeifer & Prof. Jean-Manuel Segura

•  Institute of Information Systems: Prof. Michael Schumacher & Prof. Henning Müller

•  Institut de recherche Santé-Social: Prof. Roger Hilfiker & Patricia Pham & Peter Voll

•  IEM: Prof. Eric Michellod & Prof. Alexandra Hugo

•  Institute of Tourisme: Prof. Marc Schnyder & Rafael Matos

Bottom-up!

initiative!


Vision

To position HES-SO Valais Wallis as a leader in Switzerland & internationally

in Sustainable Health Technology


Motivation •  Situation:

•  aging society, increasing numbers of patients with chronic diseases, and late-stage and expensive treatments

•  Paradigm shift is needed to enhance: •  Early detection and prevention of diseases

•  Healthy behavior & nutrition

•  Patient empowerment & health literacy

•  Chronic disease management

•  Socially integrated care and independent living

Picture source: http://www.sustainablehealth.org/sustainable-health/our-approach/


Mission of HTIC •  Create an interdisciplinary research Center on health

technology with a sufficient critical mass •  Acquire national and international research projects •  Translate fundamental research to aR&D •  Transfer innovation to industry (prototype developement) •  Transfer competencies to our students •  Position HES-SO Valais towards EPFL Valais & HES-SO


Positioning

Fundamental Research

(EPFL Valais)

aR&D (HES-SO VS)

Valorisation (The Ark)

Industry

Health Technology Innovation Center (HTIC)

Translate fundamental research into industrial practice (Science to Market)


Stategic Axes: full value chain

•  Early diagnostics tools •  Sensor developments

& integrated devices •  eHealth applications •  Healthy food

Institute of Life Technologies

Systems Engineering Institute

Institute of Information Systems

Institute of Life Technologies

ß  Focus on health innovation mainly outside hospital à

ß  Ethically-driven technology development to fully respect & serve human life à

Institut Santé S

ocial Institute of Tourism

Institute of M

angement


eHealth Unit Sierre 27 collaborators

3 professors, 7 engineers, 6 postdocs, 11 PhD students

Many visiting researchers and exchanges with other research groups & companies

60 peer reviewed publications in 2012

1 startup company in 2013. Possible others startups in preparation

Projects 2013: 8 EU FP7 projects

4 FNS + 2 Nano-Tera

CTI, TheArk, Hasler, …

Mandates


Physio-logical values

Monitoring Decision support

Electronic Health Records: (Patient history)

Individualized multi-parametric data analysis

Bio-markers & Sensors

Models (Formal reasoning and machine learning)

Medical guidelines Medical litterature

Hospitals GPs

& Nurses Labs

Interoperability

Coordination of care

Acute & Chronic individual care management

Medical data warehouse

Signal processing

Multiparametric Decision Support


HTIC Example projects


Gestational Diabetes Mellitus GDM occurs during pregnancy (4%)

due to increased resistance to insulin Goal of the project:

1.  Constant monitoring and recording to ease treatment adjustment

2.  Automatic alerts to medical staff

Technologies: Market sensors (glucometers)

Smart phones & Web Apps

Expert Systems


Demo


MIRTH

MIRTH BodyTel Body Area Network

Interoperability Middleware

Intelligent Agents (GOLEM)

Arrhythmia Detection

Breathing Detection

Noise Detection

Temporal Reasoning

Guidelines Reasoning

Physio- logical

Signals HL7

Portavita Care Management System

Events/Findings/Alerts Alerts Similar patient search Visualisation

HL7

HL7

Continuous Multi-parametric and Multi-layered analysis of Diabetes 1 & 2


Commodity12 DEMO: Hypoglicemia •  BodyTel Body Area Network, with glucose value sent the interoperability

layer

•  The expert systems applies a set of rules to deal with hypoglicemia:

•  The alert is displayed in PortaVita Care Management System


DiagnosticAID (2012-2014)

Objective: •  Interoperability with external health systems

•  Clinical decision support system backed by computerized clinical guidelines for Mediway


Measure of the Knie Deviation •  Goal: Diagnostic of arthritis

•  Means:

•  System to measure knie deviation

•  Data acquisition

•  Software for physiotherapists with data acquisition, visualization and analysis

•  HES-SO Partners:

•  Systems Engineering Institute (Pierre Roduit)

•  Institute of Health (Roger Hilfiker)

•  Institute of Information Systems (Michael Schumacher) Used sensors: gyroscope,

accelerometer, compass


NinaPro: Non Invasive Adaptive Hand Prosthetics

GOALS 1.  Augment Dexterity of Robotic Prosthesis 2.  Reduce Training Time


Step 1: Nina-Pro Electro Myography Database Step 2: Posture Classification Step 3: Natural Control Step 4: Adaptive Learning

NinaPro: Steps


Project „ISyPeM II“ Ø  Evolution in TDM

0 1 2 3 4 5 6 7 8 9 10 11 12 Treatment dura5on (days)

Drug Con

centra5o

n (μg/mL)

0.0

0.4

0.8

1.2

1.6

2.0

2.4

Pa5ent

Target

800 mg qd

Risk of adverse effects

Risk of inefficacy

Ima5nib 400 mg qd


Project „ISyPeM II“ Ø  Point-of-care (POC) solution


INTERPRETATION AND DOSE ADJUSTMENT §  Is the result expected ? §  Is the drug still suitable ? §  Prediction and dose adjustment

Project „ISyPeM II“ Ø  Point-of-care (POC) solution

DATA EXCHANGE AND INTEROPERABILITY §  Upload patient’s data §  Extension of eHealth medical standards §  Data integrity


Project Idea „Breathx“ Ø Mobile breath analysis Air composition incl. metabolites change: •  Infection (bacterial, fungi, viral) •  Injury and / or inflammation •  Disease (lung cancer, …) •  Pharmaceutical and food / beverage intake •  During exercise or rest (ventilated) •  Fitness


Project Idea „Breathx“ Ø Mobile breath analysis Goal: •  Understand relationship breathing ↔ recovery •  Optimize recovery / rehabilitation Approach: •  Select metabolic markers •  Select or develop wearable sensor device •  Software and Data management •  Clinical result evaluation


Thank you

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