Computer Application For Biological Research

Chakard Chalayut (molecularck)

Laboratory of Molecular Virology

Institute of Molecular Biology & Genetics

Mahidol University

A little bit about myself.

Bachelor degree in Microbiology at Microbiology Department, Science Faculty, KMUTT

Now. Master degree in Molecular Biology & Genetics at Institute of Molecular Biology & Genetics, Mahidol University.

Imagine ! how does the cell big?

Data storage in cell

DNA

How does the data transfer ?

So we need to know how the information go from DNA to protein.

Which region is the coding sequence?

What is the remain in the DNA?

How does the protein work?

ETC

The important of Computer in Biology Research

Human Genome Project (HGP)

What we got from HGP

Sequence of all genetic information.

Maps and Landmarks in Genome

Expressed Sequence

DNA markers

Variation of genome

Bioinformatic tools

Next of HGP

Transcriptomics

Proteomics

Functional Genomics

Animal Model Study

Gene Therapy

Computational GenomicsComputational Genomics

Computational Genomics

Is an interdisciplinary field that applies the techniques of computer science, applied mathematics, and statistics to address problems inspired by biology. Major fields in biology that use computational techniques.

Computational GenomicsBioinformatics

Computational GenomicsBioinformatics

Computational GenomicsComputational Biomodeling

the reverse transcriptase enzyme of the HIV-I virus with a molecular model of an inhibitor drug compound bound to

the enzyme's receptor pocket.

Computational GenomicsMolecular Modelling

PyMol

VMD

Computational GenomicsSystems biology

new biological study field that focuses on the systematic study of complex interactions in biological systems

TranscriptomicsProteomicsInteractomics

Glycomics

MetabolomicsFluxomics

Computational GenomicsProtein structure prediction and structural genomics

Protein Purification

Crystallization

X-ray Crystallography

Analyses

Protein Structure

For Thailand

We have BIOTECH as a leader for Computational Genomics development.

The problem for biology research from my experience.

No background knowledge of computer.

Don’t have the easy and free tools to use. (especially Thai tools)

Most of the free biology computer tools are in UNIX but most biological scientist didn’t know what is UNIX until Master degree!!! (Someone in Doctor Degree)

Most of biology science student didn’t study UNIX or biology tool but the University let they study Pascal or Dos and we don’t know how this program involve in biology research.

The science student in Thailand must learn some bioinformatics or computational biology for research the tools for biology research.

Thank you for your attention.