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2. Oyster Disease
3. Research Objectives
4. Oysters that had experienced disease pressure Oysters that had not experienced disease pressure (nave) Spawn Spawn Experimental Design 5. Oysters (~4000 from each group) were grown in a Dermo prone site- Edgartown Great Pond July 2005 - Present 6. overwintered on bottom Temperature Data 7. Mortality Nave oysters Survivors ofDiseasePressure 8. Survivors of Dermo pressure [Edgartown GP] Naive [Tisbury] 9. DERMO Perkinsus marinus Survivors of Dermo pressure [Edgartown GP] Naive [Tisbury] 10. Research Objectives
11. Photo: Gary H. Wikfors: Northeast Fisheries Science Center,NOAA Fisheries Milford Laboratory, Milford, CT Immune Response in Oysters 12. What are the biochemical orgene productsproduced by hemocytes? 13. Approach: Genetic Characterization
14. CIAPIN Expression cytokine induced apoptosis inhibitor 1 Survivors of Dermo pressure [Edgartown GP] Naive [Tisbury] Apoptosis (programmed cell death) regulationis likely involved in disease resistance 15. Survivors of Dermo pressure [Edgartown GP] Naive [Tisbury] Cathepsin L Expression Cathepsins are a family of proteasesProteases and protease inhibitors have been shown to play critical roles in immunity and host-parasite interactions.One possibility is Cathepsin L is involved inP. marinusdefense activity. 16. For more information. 17. Conclusions