10 Week End Stage

Wt 4 Week

11

Modeling PDAC metastasis

orthotopic

de novo

22

Phenotype of PDAC does not appear to be differentPhenotype of PDAC does not appear to be differentin Smo F/+ and in Smo F/F mice at 9.5 weeks of agein Smo F/+ and in Smo F/F mice at 9.5 weeks of age

PDACPDACSmo F/+Smo F/+

PDACPDACSmo F/FSmo F/F

200x 200x

33

PDACPDACSmo F/+Smo F/+

PDACPDACSmo F/FSmo F/F

400x400x

Phenotype of PDAC does not appear to be differentPhenotype of PDAC does not appear to be differentin Smo F/+ and in Smo F/F mice at 9.5 weeks of agein Smo F/+ and in Smo F/F mice at 9.5 weeks of age

44

PDACPDACSmo F/+Smo F/+

PDACPDACSmo F/FSmo F/F

55PanINsPanINs

9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/+ mice: PDAC - 100x9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/+ mice: PDAC - 100x

66930

66

9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/+ mice: PDAC - 200x

66930

77

9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/+ mice: PDAC - 100x

67397

88

9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/+ mice: PDAC - 200x

67397

99

9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/F mice: PDAC - 100x

67410

1010

9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/F mice: PDAC - 200x

67410

1111

9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/F mice: PDAC - 100x

66943

1212

9 week-old p48-Cre; LSL-Kras; p53 F/+; Smo F/F mice: PDAC - 200x

66943

1313