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Presented at the RSC Chemical Information and Computer Applications Group (CICAG) meeting "Chemical Information for the Chemist and Non-Chemist" in May 2010, these slides highlight the powerful reaction searching capabilities of SciFinder.
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6/28/2010
An Introduction to SciFinderAn Introduction to SciFinder®®
The Chemical Research Tool for ScientistsThe Chemical Research Tool for Scientists
Yvonne PopeRegional Marketing ManagerCAS
2CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Today’s discussion
SciFinder
Provides access to the world’s authority for chemical information
Offers synthetic researchers answers to their reaction questions
Speeds discovery by providing a sophisticated suite of analysis and research tools
3CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
ACS Vision
Improving people’s lives through the transforming power of chemistry
CAS is a division of the American Chemical Society
4CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
CAS supports the mission of the ACS
ACS Mission
To advance the broader chemistry enterprise and its practitioners for the benefit of Earth and its people.
CAS Commitment
To support the ACS mission by providing secure access to high-quality, comprehensive chemical information.
5CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
CAS DatabasesCAS Databases
“Being able to rapidly search for important chemical information while an idea is fresh in your mind is almost priceless.
CAS databases streamline the investigative process –
allowing you to take an idea and rapidly find the important and necessary information before you forget about the idea or it loses its excitement.
That really is invaluable.”
Dr. Robert H. GrubbsNobel Laureate
Victor and Elizabeth Atkins Professor of ChemistryCalifornia Institute of Technology
6CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
CAS is the world leader in providing chemical information…
7CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Types of reactions in CASREACT
Single-step reactions–
Single-step multi-stage reactions
Multi-step reactions
Stereo-specific syntheses
Biologically mediated reactions
Prophetic reactions from patents
8CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Begin by using the drawing editor to draw a reaction
9CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Verify search type and limiters before submitting the search
10CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Note size of initial answer set and default sort option
11CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Get similar reactions to create a new answer set
12CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Sort reaction answers to display relevant reactions
13CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Limit a solvent before a search
14CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Limit by solvents using the Solvent Hierarchy
15CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Limit by solvents using the Solvent List
16CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Case Study: Patents involving Suzuki Cross- Coupling Chemistry
I am in interested in intellectual property pertaining to SuzukiCross-Coupling Chemistry
“Difficult” to solve through structure query in any reaction database!
Coverage of patents in reaction database is important
One solution is to search text information in a database that isdirectly linked to a reaction database
17CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Use SciFinder’s
Explore by Research Topic to solve this search problem
18CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Analyze references for patents to focus on IP in this area
19CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Analyze
patented Suzuki chemistry technology areas
20CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Determine which Suzuki reactions are reported in these patents
21CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Determine which Suzuki reactions are reported in these patents
NOTE: Some reactions from these patents are not Suzuki
22CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Isolate actual Suzuki reactions with the Refine tool
B
23CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Isolate actual Suzuki reactions with the Refine tool
B
24CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Use keyword searching to identify reactions with “difficult”
chemistry
Found more than 12,000 references mentioning Suzuki in the scientific literature
–
> 800 references from patents
Found > 2,000 reactions covered in these patents
Isolated > 100 actual Suzuki reactions for review
25CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
SciFinder is a valuable resource for locating reaction information
Timely – reactions are added each week
Flexible – reaction information is seamlessly integrated with reference and substance information
Comprehensive – reaction coverage has expanded by addition of older reactions at the same time editorial scientists keep up with current literature
26CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
SciFinder is the premier enterprise-wide research discovery tool
used by scientists around the world
27CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
Questions