caBIG™ Enterprise Support Network

Leslie K. Derr, Ph.D.National Cancer Institute

Center for Biomedical Informatics and Information Technology

Background: Pilot Enterprise

• caBIG Pilot • Building Community• Delivering Products• Real Solutions to Real Problems

• caBIG Enterprise• Expand Community of stakeholders• Drive the development and adoption of interoperable

tools, standards and infrastructure to facilitate the sharing and integration of data

ESN Purpose

• Facilitate the widespread adoption of caBIG™ standards, tools and infrastructure

• Expand the support structure for end users beyond the Workspaces, caBIG Program Staff and NCI CBIIT

ESN Defined

• A collection of diverse organizations that with guidance from the NCI, caBIG Program staff, and caBIG workspaces will expand and support the caBIG community by providing appropriate services, mentoring and expertise

ESN Components

• caBIG Knowledge Centers

• caBIG Service Providers

• caBIG Program Offices

caBIG™ Knowledge Centers

• Groups working under NCI-funded contract to serve as a knowledge resource and provide limited levels of support

• Demonstrated expertise in the domain or area of focus

• External outreach to facilitate the widespread adoption of caBIG standards, tools and infrastructure across biomedical research enterprise

• Advance and codify subject matter expertise within a specific domain to deepen and broaden caBIG capabilities

caBIG™ Service Providers

• Provide comprehensive technical and end-user support

• Service Agreements are negotiated between the Service Provider and the Customer

• 3rd party entities approved by NCI as meeting specific criteria for performance in one or more service areas

• Help Desk and Phone Support• Software Development• Implementation Support• Documentation and Training Development and Delivery

caBIG™ Program Offices

• May be partially funded by the NCI

• Established at institutions and organizations interested in deploying caBIG tools and infrastructure across multiple departments within an institution or broadly across an organization

• Coordinate efforts so that caBIG can serve as an integrating technology platform

Recipients of ESN

• Current caBIG community and broader biomedical research community

• Supports the needs of individuals, institutions and organizations adopting caBIG standards, applications, and infrastructure, including IT administrators, end users, administrators and senior decision makers

Centrality of the caBIG Workspace

• Serve as a Forum for all Stakeholders • NCI • caBIG Program Staff• Developers• Adopters• Subject Matter Experts• Patient Advocates• KC Representative• Service Providers• Pharma, biotech, etc.

Centrality of the caBIG Workspace (cont’d)

Activities of Workspace• Provide the key forum for stakeholders/ information

exchange• Identify needs• Identify requirements• Determine priorities• Set strategic direction of WS• Bug detection• Required/desired enhancements• Open Development and testing

Knowledge Centers currently proposed

• Tissue Biospecimen/Banking Tools

• Clinical Trials Management Systems

• Molecular Analysis Tools

• caGrid

• Compatibility

• Data Sharing and Intellectual Capital

caBIG™ Knowledge Centers

What They Provide• No cost support to the end-user community• Stable, predictable, and publicly-available repository for

caBIG technology and information base• Versioned source code• Comprehensive documentation• New code committed by the community• Domain expertise• Forums and responses• Domain-relevant training/ train the trainer

• Authoritative, stable and publicly-available repository of policies and standards

• Infrastructure for an open source development community• Community Outreach – supporting the goals and advancing

the work of caBIG

All software and documentation will be delivered to and housed on NCI-controlled server

caBIG™ Service Providers

What They Provide

• 3rd party support of end-user community• On-site installation and integration of caBIG tools• Data extraction, translation, and loading based on caBIG

standards• Time-critical end user support• caBIG tool customization• On-demand end user training

caBIG™ Program Offices

What They Provide

• Capacity to provide on site expertise and points of contact to manage caBIG technology deployments for defined institution or organization

• Broad-based caBIG knowledge management• Coordination of tool workflow integration• Technology education and tutorials• Coordination of inter-departmental technology usage• Communication of new caBIG program and technology

updates• Monitoring and reporting of caBIG usage and adoption

Software Development

Workspace Identify needs and requirementsSet priorities within the domain for new reference implementations – competitive RFPIdentify bugs in existing softwareDefine minor and major (competitive RFP) enhancements required/desired for existing software, and determine the priorities Needs/Priorities of the WS will reflect the general needs of the community

Knowledge Center Minor enhancements to existing software based upon WS priorities Custodian of software code base maintained in dynamic fashionFoster open development

Service Provider Shrink wrap and provide full-featuredapplications from caBIG-funded reference implementationsCustomize applications to meet individualuser needsSpeculative development based onworkspace discussions/end-user needs

Documentation and Training

Workspace Awardee is responsible for creatingdocumentation and training for caBIGfunded developmentDevelop requirements for model documents,position papers, best practices (if complex orspecialized – competitive RFP)

Knowledge Center Maintaining current supportingdocumentation and training for existingtools within their domainPost outreach and educational materials onWebsiteCreate model documents, position papers,training to meet requirements and strategicpriorities of workspace

Service Provider Tailor documentation and training for specific user groupsProvide on-demand training

Traversing the ESN

Case Study: Principal Investigator (PI) needs a biospecimen repository

• Contacts caBIG Program Office (PO)• PO staff point PI to Tissue/Biospecimen Banking Tools Knowledge

Center (KC)• PI visits KC website, discovers caTissue fulfills needs, downloads

software and associated documentation• PI contacts caBIG designated Service Provider to assist with

installation and data migration• After using caTissue for several months, PI desires additional

functionality • Contacts KC where a number of options are presented

• Participation in TBPT WS where needs are identified and priorities set

• Negotiation with caBIG Service Provider for custom enhancement• PO office canvasses across institution to identify other PIs with

common need

Pilot Enterprise Adopter (EA) Program

• Short term program to assist IT administrators and application end users integrate caBIG tools and infrastructure in support of their research efforts

• Tissue/Biospecimen Banking – caTissue Adoption• Clinical Trials Data Management -C3D Adoption

Enterprise Adopters

Enterprise Adopters: caBIG™ Software Integration SupportApplication End Users and IT Administrators Receive

• Helpdesk telephone support• Technical support provided by caBIG™ program

representatives and partners• On-site support from caBIG™ application development teams,

if appropriate • Support through funded attendance, as appropriate, at

Application End-User Meetings

Enterprise Adopters

Enterprise Adopters: caBIG™ Software Integration Are expected to

• Integrate caBIG™ tools into their workflow in support of their research efforts

• Share a pre-defined data set used in adoption activities through caBIG™ silver-compatible APIs or caGrid-enabled data services

• Provide a written summary of lessons learned

Currently being piloted with TBPT suite of tools

Cancer Central Clinical Database (C3D ) Adoption

Enterprise Adopters: C3D Integration SupportApplication End Users and IT Administrators Receive

• Helpdesk telephone support• C3D user licenses for use in cancer studies only• Electronic Case Report Form (eCRF) templates, co-branded

with the C3D Adopter’s logo(s)• Oracle Clinical Remote Data Capture (RDC) and Protocol

Builder training for cancer clinical research team members• Cancer Data Standards Repository (caDSR) training • Standards implementation and Common Data Element

(CDE) /template selection assistance for 1-2 studies• eCRF annotation assistance for 1-2 pilot studies• CDE curation services • Protocol Building services for 1-2 cancer clinical research

studies• CTMS Best Practices Documentation

Cancer Central Clinical Database (C3D ) Adoption

Enterprise Adopters: C3D Integration SupportAre expected to

• Integrate C3D into their workflow in support of their cancer clinical research efforts

• Embrace and apply recommended caBIG standards (CDEs, template forms and procedures, development guidelines, etc.) and contribute suggestions for their enhancement as appropriate

• Make a pre-defined set of data stored in or generated through the use of C3D accessible for sharing through caBIG™ silver-compatible application programming interfaces (API) or caGrid-enabled data services, subject to applicable regulations and IRB requirements

What Who

Supporting the caBIG™ Enterprise

Program

Offices

Service Providers

caBIG™ Enterprise

• 3rd party entities • Services open to all caBIG™ institutions

• Comprehensive technical and end-user support

• Domain experts • Services open to all caBIG™ institutions

• Expertise in a specific domain or area of focus

• caBIG™ teams set-up within institutions or organizations

• Services focused within the institution or organization

• Coordinate caBIG™ efforts within institution or across organization

Knowledge Centers

caBIG Workspace: Key Stakeholder Forum Identifying Needs, Determining Requirements, Setting Priorities Ongoing Tool Development, Adoption and Participation