Ibogaine and cellular metabolism

Traditional use of Iboga

enteogen - ritual drug oneirogen - awake

dreams psychostimulant and

tonic reconvalescence after

infectious diseases aphrodisiac

Use of Iboga/ibogaine in the West

interruption of addiction to alcohol, opiates, nicotine in cocaine

spiritual growth and self-realization

holly sacrament use at extreme sports –

mountaineering interesting for army

Ibogaine in medicine

1905: 10–30mg per day against asthenia

1939-1970: neuromuscular stimulant 8mg per pill against fatigue, depression and at reconvalescence after infectious diseases

1969: 4-5mg/kg as fantasy enhancer at psychotherapy

Pharmacodynamics of ibogaine

immediate (acute) effect

prolonged effect

Pharmacodynamics of ibogaine

effects last longer than the presence of ibogaine in the body

fat deposits of lipophillic metabolite cannot directly cause the effect for weeks or months

functional and structural changes are expected

Composition of cell

•nucleic acids

•proteins

•polysaccharides

•lipids

•water

Proteins

•structural •functional

Structural proteins-cytoskeleton

Functional proteins-receptor

Functional proteins-enzyme

Protein separation by 2-D electrophoresis

Computer scan of gel

Computer scan of gel

“In silico” analysis of results

Spots of interest

Peptide mapping by mass spectrometry

Identification of proteins by matching with data bases

Induction of energy metabolism related enzymes in rat brain

Enzyme Fold

24 h

Fold

72 h

Mr(Da)/pI Score Peptide matching

Glyceraldehyde-3-phosphate dehydrogenase

1.13 3.21 36090/8.14 62 9

Malate dehydrogenase

1.42 3.64 36117/8.79 54 9

Aldolase 1.23 2.45 39783/8.05 60 9

Pyruvate kinase 1.38 2.94 58314/7.19 70 10

Induction of energy metabolism related enzymes

Nonspecific activation of metabolism

Interpretation of results

Enhanced energy availability supports higher metabolic turnover and by that facilitates detoxification and renewal of tissues.

Besides, consequent mental agility provides insight into one’s own psychological state

Aura and ibogaine

-40 min +3 h

+54 h

Aura and ibogaine

Aura and ibogaine –thantanosis

Aura and ibogaine

Aura and ibogaine

Aura and ibogaine

Maybe illumination and revelation are proper words to describe what is at this moment difficult to explain

Pharmacodynamics of Entheogen Drugs - Influence on Gene Expression

- Faculty of Pharmacy, UL - Biotechnical Faculty, UL - Faculty of Medicine, UL

- Faculte de Pharmacie, Universite Montpellier 1, Montpellier, France

- Institute for Biological Research Siniša Stankovic, Belgrade, Serbia

OMI,Institute of Anthropological Medicine

www.omi.si