Sequence Services Phase 2--Hewlett-Packard

© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice.

HP Sequence ServicesPistoia Alliance Annual Conference

24th April 2012

Etzard Stolte, PhD, Hewlett-PackardRalph Schlapbach, PhD, ETH Zurich

© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. HP Restricted

Technical / Scientific SupportTechnical & scientific QCProfessional life cycle management of bioinformatics tools and scientific quality control of analysis results

HP Cloud / Data Center Secure & scalable infrastructureHP’s consolidated IT infrastructure provides a flexible storage and compute both as services as well as public service

HP Sequence ServicesHigh scientific quality with maximal IT flexibility

Functional Platform

Mature functional platformComplete coverage of NGS workflows within proven data management and analysis system

© Copyright 2011 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice. 3

HP is the world's largest provider of IT infrastructure, software, services, and solutions to individuals and organizations of all sizes.• Fortune 11 – U.S.

• Fortune 28 – Global

• Doing business in approximately170 countries

• Over 320,000 employees


Life science data management, analysis, and integrationFunctional Genomics Center Zurich

•Joint Swiss research and technology center of University Zurich & ETH

Zurich21 Nobel Laureates since beginning last century, 215 spin-offs since late nineties

•Comprehensive coverage of systems-oriented life science research

areasGenomics, Transcriptomics, Proteomics, Metabolomics

•Full project support in User Lab conceptScientific consulting, project consulting, researcher training, project collaboration, data

analysis QC

•10 Years of operational experience> 2000 Users, > 1000 Projects, > 240 Institutes, > 30 Companies

•Full coverage of state-of-the-art analytical technologies> 30 platforms, e.g. PacBio RS, Illumina HiSeq2000, LifeTech SOLiD5500xl, IonTorrent PGM, Roche/454 GS

FLX+

4


Functionality overviewHP Sequence Services

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• Easy-to-use

• Cost-effective

• Increased scientific quality

• Comprehensive administration

• Powerful HP Cloud

• Industry leading security

• Open standards based


World-class, open standards based, secure cloud infrastructure

HP Converged Infrastructure – Private or Public

• Adapt to changing needs

• Scale up dynamically

• Access your data globally

• Pay only what you use

• No lock-in through open standards

• Hybrid approach (private/public)


Sequencing in personalized medicine and resulting challenges

HP Sequence Services

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Diseasemechanism

Therapy DiseaseHealthy

Diseasecause

Therapeuticmeasure

Understandingof disease mechanism

Developmentof therapy

Diagnosticcharacterization

of disease

Characterizationof disease agent

Personalizedapplication of

therapeutic agent

Geneticcharacterization

of indvidual


Technical & scientific supportHP Sequence Services

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• NGS analysis challenges at all levels• Experimental (specimen, molecular biology)

• Data management (terabytes per experiment)

• Data processing (large memory needs, large computational needs)

• Data processing and interpretation (algorithms, statistics, visualization)

• Technical and administrative support• Project setup and management, application support, scalability, special hardware requirement

• Scientific support• Essential at all levels of a successful project (beginning with experimental design)

• Feedback loops between bioinformatics and lab necessary to assess and enhance quality of

output


Sequenceread the genetic code

Mapplace the reads on reference genome

Identifyfind SNPs, Indels and structural variations

Associatelink genetic changes to diseases

Validatevisualize results in Genome Browser

(c) Nature & ETH/UNI


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Functional platform offering complete coverage of NGS workflows


Data analysis from single experiments to data integrationHP Sequence Services

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Read processing• De-multiplexing• Trimming• Quality control

Read mapping• Alignment• Combination• Statistics

Functional association• Element identification• Element association

Validation• Result

visualization• Scientific

validation


Data analysis from single experiments to data integrationHP Sequence Services

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Illumina, SOLiD, 454, IonTorrent, PacBio

Data combination• Long / short reads• Bias / error rates

Data integration• Other molecular

levels• Other technologies

Proteomics, Metabolomics

Hypothesisgeneration / validation

Data and knowledge export and linking

Collaboration• Technical

discussion• Scientific exchange

Communication, member management


Roadmap


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April July Dec

Pilot

• Transform platform• In-house data center• Minimal app set• Develop Web GUI• User acceptance

tests• Demo data (35 GB)

Release

• Extend platform

• HP Cloud 10th May

• LCM core apps

• Email based admin workflows

• Service ramp-up

Production

• Commercialize platform• Region specific data

center• Integrate extended app

set• Billing, pay-as-you-go• Technical & scientific

support• Concept-based search• Partner program

commercialdevelopment2012 2013

today


Three models starting 2013 – HP Cloud, in-house, or bothHP Sequence Services

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HP Cloud Subscription• Project setup• System training• Public data

sources

In-house HP data center• Run functional platform in-

house• HP platform support• Burst-out to HP Cloud (opt.)

Pay-by-use/project• Storage/Compute• Consultancy• Custom

applications


High scientific quality with maximal IT flexibilityHP Sequence Services

• Complete administration• Automated administration tasks• Simplified IT admin, scientists,

secretarial work

• Increased scientific quality• Reproducibility of research results• Application life-cycle-

management• Scientific quality control & support• Meaning based search

• Open standards based• Community application approach• Easily extensible with new

applications• No vendor lock-in with OpenStack

• Easy-to-use• Easy & fast web-based data

access• Standard & ad-hoc analysis

workflows

• Industry leading security• Role-based user authorization• Regular security and quality

reviews

• Cost-effective• Transparent subscription & pay-

by-use• Public data life-cycle-management

• Powerful Search & HP Cloud• Dynamic storage & compute

power on the HP Cloud• Hybrid Cloud models

• John Wise• Michael

Braxenthaler• Nick Lynch• Ashley George• Deborah Ausman• -------

A true catalyst for the Pharma- and IT industries


THANK YOU

Technology

Sequence Services Phase 2--Hewlett-Packard