A Team Science Approach to Nicotine Dependence Treatment Caryn Lerman, Ph.D. Center for...
Preview:
Citation preview
- Slide 1
- A Team Science Approach to Nicotine Dependence Treatment Caryn
Lerman, Ph.D. Center for Interdisciplinary Research on Nicotine
Addiction
- Slide 2
- Continuum of Research Teams Investigator works largely
independently on research problem in own lab Each group member
brings expertise to address research problems Group members work on
separate parts of research problem which later become integrated
Data sharing or brainstorming varies from limited to frequent Each
team member brings expertise to address common research problem
Teams meet regularly to discuss team goals, individuals objectives
and next steps Team shares leadership responsibility, decision
authority, data and credit Level of Interaction and Integration
LowHigh IndividualCollaboration Team Science
- Slide 3
- Team Science 1.Get the right people on the bus. 2.Develop a
collective vision to address an important scientific, clinical, and
or public health problem. 3.Identify a unifying theme that can/must
be addressed from a multi-disciplinary perspective. 4.Generate a
common conceptual model that links individual scientific projects
to address the problem. 5.Develop a common vocabulary through
cross-education of team members. 6.Meet often to facilitate synergy
across projects and communicate goals and interests. 7.Support
junior investigators in all aspects of career development.
- Slide 4
- Who to get on the bus? Team Science Essentials (smart is not
sufficient) Creative Open (cognitive flexibility) Dependable
Accessible team science takes extra time
- Slide 5
- Common vision: Elucidate the cellular, molecular and neural
regulation of cognitive and affective responses that promote
relapse, and translate findings to improve therapy for nicotine
dependence (2009-2014) Julie Blendy multi-PI CIRNA Center for
Interdisciplinary Research on Nicotine Addiction (1999- )
- Slide 6
- Common Conceptual Model Cellular and genomic studies to
identify potential targets Screening of novel compounds and
repurposed meds Cognitive, neurobiological markers of medication
effects A focus on the key clinical endpoint: relapse
- Slide 7
- A Translational Research Example Opioid genetic mechanisms in
nicotine reward and relapse Exon1 *
- Slide 8
- Opioid Mechanisms in Nicotine Reward Nestler
- Slide 9
- Mouse Model of Nicotine Reward Preconditioning Day A B DRUG
SALINE C C C C S S S S ?? Day 1 Pairing Days 2-8 Test Day Blendy
Lab
- Slide 10
- Naloxone on Test Day Blocks Conditioned Rewarding Effects of
Nicotine in 129/C57 B16 Mice Saline Nicotine (1.0mg/kg) Treatment
on Test Day *p