View
225
Download
1
Category
Preview:
Citation preview
American Heart AssociationResearch Program Overview
SouthWest AffiliateFebruary 2014
Mission
BUILDING HEALTHIER LIVES, FREE OF CARDIOVASCULAR DISEASES
AND STROKE
We will have an extraordinary impact on your life by empowering you and your loved ones to save lives, live healthier and enjoy more peace of mind about cardiovascular health.
Impact Goal
By 2020 to improve the cardiovascular health of all Americans by 20 percent while reducing deaths from cardiovascular diseases and stroke by 20 percent.
Research - AHA Top Priority
The AHA believes that learning more about the #1 and #3 killers in America is one of the best ways to
accomplish our mission.
Click icon to add picture
RESEARCH GOALSTo discover new
knowledge broadly related to the normal
function of the CV system and the causes,
prevention, treatment or control of CVD and
stroke.
• Ensure that highly meritorious research and discovery continues, including supporting early career investigators
• Increase the capacity of the research community to generate the highest quality research
• Promote a research infrastructure that expedites the translation of basic, clinical, behavioral and population research into practice
TYPES OF RESEARCH
Basic Research Clinical Research Population Health
Fundamental research is the study of life processes that are universal in their application to scientific knowledge
Example: Childhood Obesity
Early life determinants of metabolic syndrome in animal models: Interaction of perinatal environment and genetic predisposition
Addresses important questions of normal function and disease using human subjects
Example: Childhood Obesity
Binge eating, purging, and CV risk in adolescents; The effect of weight-loss diets varying in protein and carbohydrate content on markers of CV risk
Studies the distribution and determinants of health status as influenced by social, economic & physical environments, human biology, health policy & services, & disease prevention, prolonging life and promoting health at the population level
Example: Childhood ObesityWalking to school vs. riding a bus to increase physical activity and attenuate rising BMI of elementary school children
6
Donor Dollar
28¢
25¢ 75¢
National Center
SWA Affiliate
ResearchAllocation
15¢ Research60¢ Programs, Projects, Operations
13¢ Awards & Grants12¢ Programs, Projects, Operations
Publicly Donated Dollar
INVESTIGATOR-INITIATED RESEARCH FUNDING BY TYPE: BASIC/CLINICAL/POPULATION 2012-2013 AHA NATIONAL AND AFFILIATE FUNDING BY RESEARCH TYPE *PRELIMINARY FIGURES Clinical
13.4%$20M
Population3%
$4.5M
Basic83.6%$97.6M
Research Facts 2012
AHA-Funded Breakthroughs Our research funding has led to the discovery and
development of many treatments and procedures:
– First artificial heart valve– Techniques and standards for CPR– Implantable pacemakers– Treatment for infant respiratory distress syndrome– Cholesterol inhibitors– Drug-coated stents– Microsurgery– Links between dietary fat and cholesterol
Research Advancements
Funded by the American Heart Association:
1956 – Dr. Ancel Keys links dietary fat with cholesterol.
1957 – Dr. William Wierich joined by Drs. Vincent Gott and Walter Lillehei implant the first externally powered pacemaker.
1966 – Dr. Maurice Sokolow announces results of his 20-year study showing hypertension can decrease life expectancy.
1972 – Dr. Arthur Guyton provides evidence of the overriding dominance of the kidneys in long-term regulation of blood pressure and in hypertension.
1985 - Dr. Joseph Goldstein and Dr. Michael Brown provide new insights into the ways fatty cholesterol enters body cells and why cholesterol levels my become too high.
1992 – Dr. Edwin Krebs joined by Dr. Edmond Fischer discover how proteins are switched to perform functions within the cells.
1998 – Dr. Andrew Marks develops a method to reduce re-blocking of the arteries after angioplasty.
National Research Statistics
• AHA has spent > $3.5 billion on research since 1949 • AHA spent more than $134 million for new research
in 2013• Currently funds about 2,100 scientists in US• AHA is 2nd only to NHLBI in funding heart research• AHA has funded the winners of 13 Nobel Prizes• To avoid losing generations of researchers, AHA
awards more than 73% of the research dollars to early career investigators ($99.37 Million)
Advocate for NIH Funding• AHA advocates each year to increase research
funding for the National Institute of Healthy
• 2013 the NIH funded over $1.5 Billion in SWA Arkansas $ 47 Million
Colorado $ 316 MillionNew Mexico $ 90 MillionOklahoma $ 88 MillionTexas $ 956 Million Wyoming $ 8 MillionSWA Total $ 1.5 Billion
SWA Research Statistics Fiscal Year 2013
• AHA currently funds over $40 million in research in SWA • AHA currently funds 246 researchers in 36 institutions in
22 cities • SWA received over 634 applications in 2013• Overall success rate for 2013 applications is 16.2%• AHA has funded more than $442 million in research in
SWA states since 1951
SWA States: AR, CO, NM, OK, TX and WY
Affiliate Research FundingAs of February 2014, SWA currently funds over $40 million in active research awards.
Arkansas $ 925,000Colorado $ 9,020,338New Mexico $ 1,248,000Oklahoma $ 3,993,392Texas $25,464,220Wyoming
SWA Total $40,650,950
Arkansas Research Statistics
• Since 1951, AHA has funded more than $25 million in research in Arkansas
• AHA currently funds $925,000 in research in Arkansas
• AHA currently funds 10 projects in 1 institution
Colorado Research Statistics
• AHA currently funds $9,020,338 in research in Colorado• AHA currently funds 53 projects in 6 institutions
New Mexico Research Statistics
• Since 1951, AHA has funded more than $12 million in research in New Mexico
• AHA is currently funding $1,248,000 in research in
New Mexico• AHA currently funds 9 projects in 1 institutions
Oklahoma Research Statistics
• Since 1951, AHA has funded more than $38 million in research in
• AHA is currently funding $3,993,392 in research in Oklahoma
• AHA currently funds 27 projects in 3 institutions
Oklahoma
Texas Research Statistics
• Since 1951, AHA has funded more than $374 million in research in Texas
• AHA is currently funding $25,464,220 in research in Texas
• AHA currently funds 147 projects in 25 institutions
Wyoming Research Statistics
• Since 1981, we have funded $1,445,688 in Wyoming• In 2010, we funded 1 award totaling $90,772
Note: No change in funding
North Texas Research Statistics
• AHA has funded more than $191 million in research in DFW since 1951
• AHA is currently funding $5,781,448 million in DFW• AHA currently funds 33 projects in 2 institutions in DFW
Dallas $ 5,052,448 Arlington $ 140,000Fort Worth $ 729,000 Richardson $ 140,000
Note: No current funding in Denton
Houston Area Research Statistics
• Since 1951, AHA has funded more than $137 million in research in Houston & $20 million in Galveston
• AHA currently funds $ 10,279,538 in research in Houston • AHA currently funds 57 projects in 8 institutions• AHA currently funds $ 1,266,612 in research in Galveston• AHA currently funds 7 projects in 1 institution
$ 10,279,538 in Houston$ 1,266,612 in Galveston
San Antonio Research Statistics
• Since 1951, AHA has funded more than $46 million in research in San Antonio
• AHA is currently funding $2,364,232 in research in
San Antonio • AHA currently funds 15 projects in 4 institutions
Denver Research Statistics
• AHA is currently funding $8,016,348 in research in Denver
• AHA currently funds 43 projects in 3 institutions
Life Cycle of a Research Application
Hmm…
Application submitted
An idea begins
Peer Review Committee
E-mail notification
Research completed
Yea!
Reports Published
Findings translated
Assigned to reviewers
Critique developed
Rank-ordered list
Research Committee $ Funded
Research Programs
NATIONAL CENTER AWARDSo Fellow-to-Faculty Awardo Scientist Development Granto Innovative Research Granto Established Investigator Awardo Mentored Clinical & Population
Research Programo Strategically- Focused Research
Networkso Mentor/AHA Mentee Awardo Collaborative Science Awardo Merit Award
SWA AWARDS
o Predoctoral Fellowship
o Postdoctoral Fellowship
o Beginning Grant-in-Aid
o Grant-in-Aid
o Mentored Clinical & Population Research Program
o Undergraduate Student Program
The AHA supports research broadly related to cardiovascular function and disease, stroke or to related clinical, basic science, bioengineering or biotechnology, and public health problems.
SWA’S RESEARCH PROGRAMS
Program DescriptionAward Size
Award Duration
Undergraduate Research Fellowship (Pilot Program)
Help students initiate careers in cardiovascular & stroke research $4,000
total 10 wks.
Predoctoral Fellowship
Help undergraduate students initiate careers in cardiovascular & stroke researchTarget Audience: PhD, MD Students
$25,000per yr.
MAX= $50,000
1-2 yrs.
Postdoctoral Fellowship
Provide training for & encourages pursuit of research careersTarget Audience: PhD, MD not yet independent
$44,264-59,180 per yr.
2 yrs.
Mentored Clinical & Population Research Program
Encourage early career investigators to engage in high-quality introductory & pilot clinical or population studiesTarget Audience: Early career health care professionals with a Masters, M.D., D.O. or Ph.D. degree.
$70,000per yr.MAX=
$140,0002 yrs.
SWA’S RESEARCH PROGRAMS
Program DescriptionAward Size
Award Duration
Beginning Grant-In-Aid
Promote independent status of promising beginning scientistsTarget Audience: First faculty/staff appt through Asst Professor
$70,000per yr.MAX=
$140,0002 yrs.
Grant-In-Aid Support innovative, highly meritorious cardiovascular & stroke research projects from independent investigatorsTarget Audience: All levels of faculty/staff members
$70,000per yr.MAX=
$140,0002 yrs.
Scientist Development Grant
Help promising beginning scientists move from completion of research training to independent investigatorsTarget Audience: No more than 4 years since first faculty/staff appt
$60,000 per yr.
3 or 4 yrs.
AHA’S RESEARCH PROGRAMS
Program DescriptionAward Size
Award Duration
Innovative Research Grant (Pilot Program)
Support highly innovative, high-risk, high-reward research that could ultimately lead to critical discoveries or major advancements that will accelerate the field of cardiovascular & stroke researchTarget Audience: All levels of faculty/staff members
$75,000 per yr.
2 yrs.
Established Investigator Award
Support mid-term investigators with unusual promise, an established record of accomplishments, & a demonstrated commitment to cardiovascular & stroke researchTarget Audience: 4-9 yrs since first faculty/staff appt
$100,000 per yr.
5 yrs.
Fellow-to-Faculty Transition Award
Provide funding for beginning physician-scientists with outstanding potential for careers in cardiovascular & stroke researchTarget Audience M.D., M.D./PhD., D.O. or equivalent; not yet at faculty/staff position
$593,000 total
5 yrs.
Collaborative Science Award
Fosters innovative, new collaborations between two or more principal investigators from different science areas leading to unique and novel discoveriesTarget Audience: Target Audience: All levels of faculty/staff members
$250,000 per yr.
3 yrs.
AHA’S RESEARCH PROGRAMS
Program DescriptionAward Size
Award Duration
Mentor/AHA Mentee Award
Award to fund mentors working with mentees meeting specific criteria, including: underserved minorities, those working in new/difficult areas of inquiry and mentees at NIH AREA designated institutionsTarget Audience: Faculty /staff with proven mentoring success
$20,000 per yr.
3 yrs.
Strategically - Focused Research Networks
Provides a platform to address key strategic issues, chosen by the AHA Board of Directors, in CVD and stroke. Includes 3-4 institutions conducting 3 projects each.Target Audience: All levels of faculty/staff, members including Fellows
$3-5M per yr.
4 yrs.
AHA Merit Award(Available FY 15-16)
Funds highly competent individuals with an exceptional track record of success. Potential awardees must be renowned for creativity and embracing the unknownTarget Audience: 10 years but no more than 20 years since first faculty/staff appt
$200,000 per yr.
5 yrs.
SWA Success Rate by Program2013
Program Type Description
Number of Applications
Received
Number Funded Success Rate
Beginning Grant-in-Aid 140 14 10
Grant-in-Aid 200 32 16Postdoctoral Fellowship 163 28 17.2Predoctoral Fellowship 112 24 21.4
Clinical Research Program 6 0
Undergraduate Fellowship 9 4 44.4
Grand Total 630 102 16.2%
The Process – SWA Spring Funding
January February March
April May July
• Application Deadline
• Applications assigned to Committees
• Committee Chairs review assignments
• Committee Chairs finalize assignments
• Reviewers input preference
• Assignments sent to reviewers
• Peer Review Committee meets
• Research Committees meet
• Award Notification
• Award activation
The Process – SWA Fall Funding
July August September
October November January
• Application Deadline
• Applications assigned to Committees
• Committee Chairs review assignments
• Committee Chairs finalize assignments
• Reviewers input preference
• Assignments sent to reviewers
• Peer Review Committee meets
• Research Committees meet
• Award Notification
• Award activation
Application Process
What can you do to prepare for the application process?– Notify your third parties that you plan to apply – Develop your research plan and specific aims– Begin to recruit referents if you are a fellow– Develop your training plan with your sponsor if you are a fellow – Check with your Grants Office for internal institutional deadlines
Go to www.heart.org/research
Please call our department at 214-712-1328 or email at research@heart.org with questions
RESEARCH INFORMATIONKey Websites
PROGRAMS, DEADLINES, APPLICATIONS & GRANTS@HEART LOGIN-IN http://my.americanheart.org/professional/Research/FundingOpportunities/Funding-Opportunities_UCM_316909_SubHomePage.jsp
GENERAL INFORMATION ABOUT RESEARCH http://my.americanheart.org/professional/Research/Research_UCM_316889_SubHomePage.jsp
EMAIL ADDRESS FOR PROGRAM OR TECHNICAL QUESTIONSapply@heart.org
Reminders• Research broadly related to cardiovascular function and disease,
stroke, or to related basic science, clinical, bioengineering or biotechnology, and public health problems
• Consider criteria and evaluation priorities• All basic disciplines as well as epidemiological, behavioral,
community and clinical investigations• Citizenship: US, permanent resident, Visa, E-3, etc.• Sponsor criteria and support (see application instructions)• Budget amounts for stipend/salary, project support, fringe benefits,
travel, indirect costs and maximum annual amount• Eligibility by virtue of degree, faculty rank, independence, years of
experience, percentage of effort, citizenship, sponsor support, restrictions, location of work and overlap of funding
• Repeat applications (up to 3 times including original)• Full assessment of peer review ongoing
AHA Professional Membership/Scientific Council
Scientific Statements/Guidelines
Scientific Sessions, Conferences and Workshops
AHA Scientific Journals
Other AHA Scientific Products
www.myamericanheart.org
Recommended