View
1
Download
0
Category
Preview:
Citation preview
AVIAN INFLUENZA AND
THE IZSVE BIOBANKMaria Serena Beato, Isabella Monne, Calogero Terregino
EU-NRLs Annual Meeting, Padova, 21 June 2019
SCIENTIFIC COLLECTIONS
Biological Resource Centres (BRCs)
BRCs are an essential part of the infrastructure underpinning biotechnology. Theyconsist of service providers and repositories of the living cells, genomes of organism,and information relating to heredity and the functions of biological systems. BRCscontain collection of culturable organism, replicable parts of these, viable but not yetculturable organism cells and tissues, as well as data bases containing molecular,physioligical and structural information relevant to these collecions and relatedbioinformatics. BRCs must meet the high standards of quality and expertisedemanded by the international community of scientist and industry for the delivery ofbiological information and materials. They must provide access to biological resourceson which R&D in the life sciences and the advancement of biotechnology depends.
Organisation for Economic Co-operation and Development (OECD/OCSE) Best Practice guidelines for BRC
BiotechnologyMaterials
DataService
Expertise
• Professional repositories of biological samples (Paskal et al., 2018)
• Long term storage and conservation facility for biological specimens to support future investigations (EC, 2006)
• Essential research tool, Web
• Functional units
• Scientific community service (Morente et al., 2008)
• Service tool (Morente et al., 2008)
• Long-term storage of biological samples for research or clinical purposes (Hallmans and Vaught, 2011)
HOW DO OTHERS DEFINE BIOBANKS?
FUNCTIONS
ACCESS INNOVATION
• POPULATION-BASED BIOBANKS: VOLUNTEERS• DISEASE ORIENTED BIOBANKS: INCLUSION AND EXCLUSION CRITERIA• TISSUE BIOBANKS: CANCER• MULTIPLE PURPOSES BIOBANKS: COMBINATIONS USING NOVEL AND WELL REGULATED TOOLS
TYPES OF BIOBANKS
From Paskal et al., 2018
WHO IS INTERESTED IN BIOBANKS?
EVERYONE, THE SOCIETY
6.Gene drive7.Advanced reproductive technologies8.Double-stranded RNA9.Syntetic alternatives to wildlife products
2. Ancient DNA3.Genome sequencing4. Bioinformatics5.Genome editing
PNAS, 2016
BIOBANKS AND INFECTIOUS DISEASES: a successful story
THE ROLE OF BIOBANKS FOR INFECTIOUS DISEASES: a less successful story
• 2008: Ebola positive sera• 2009: Ebola antibodies detected in
Ghanaian bats (2012 report)• 2016: Ebola outbreaks
• 1.6 billion dollars mobilized by the World Bank for Ebola
Could the Ebola outbreak havebeen different if small investiments
had been made to collect fieldsamples after the intial report?
• 50% of published research cannot be replicated
• In 2000-2010, 80,000 patients took part in studiesthat were later retracted beacuse of mistakes or
improperties
BIOBANKS AND RESEARCH
-Only 0.95% of the 20,200 strains includedin the 2008 issues of 8 EuropeanMicrobiology Journal were deposited in public collections
-Only 0.03% of 12,000 strains included in 2 2009 issues of the Journal of Clinical Microbiology are deposited in public collections
WHO IS INTERESTED IN BIOBANKS?
DEPOSITING IN A BIOBANK IS WORTHWILE!!!!
PAPERS ASSOCIATED TO A BIOBANK CODE HAVE A CITATION RATE 220% HIGHER THAN OTHERS PAPERS
TO TAKE VETERINARY MEDICINE TO A NEW LEVEL
BRINGING THE BIOBANKING TOOL TO REFERENCE LABORATORIES ACTIVITIES
WHY A VETERINARY BIOBANK
HOW
OUR PREDECESSORS
IZSVE BIOBANKCollection, storage of diagnostic biological resources by the IZSVe
reference laboratories
UNIQUE
EPIDEMICS
EMERGENT DISEASES
SCIENTIFICALLY RELEVANT
SAMPLETISSUE
ORGAN
LAB TEST HOMOGENATE
Modification
PATHOGEN ISOLATION
VIRUS
BACTERIA
Modifications
TEST RESULTS
TEMPORARY STORAGE DURING LAB TESTS
LAB REPOSITORY
BIOBANK
Modification(quality controls)
2014 – Involvement of the AI and ND National and OIE/FAO RL
2015 - Involvement of the National and FAO Rabies RL
2016 - nowadays – Strenghthening the activities for RL and for non RL at the IZSVe
CHRONICLE
THE ITALIAN NETWORK OF VETERINARY BIOBANKS
2013 –Set-up of the network
COORDINATOR: The Lombardy and Emilia Romagna Experimental Institute(IZSLER) , software development
OTHER EXPERIMENTAL INSTITUTES (II.ZZ.SS) INVOLVED: IZSVe, IZSSICILIA, IZSPLV, IZSAM
IZSLER HAS BEEN APPOINTED AS:OIE COLLABORATING CENTRE FOR VETERINARY BIOLOGICAL BIOBANK
Biological
materials
Data
Expertise
AvianInfluenza Biobank
ARE WE READY FOR BIOBANKING?
From the 1° report of the Multidisciplinary workshop on EID, Sci Coll, 2015
HOW WE WOULD LIKE TO USE THE AVIAN INFLUENZA BIOBANK
WHAT DO WE ALREADY HAVE?
WHAT DO WE ALREADY HAVE?
WHAT DO WE ALREADY HAVE?
ON LINE CATALOGUE
ON LINE CATALOGUE
Emerging Diseases
Environmental change
Food security
Human migration
DURING THE NEXT OUTBREAK……
KEEP CALM
AND
DEPOSIT
Recommended