ChemInform Abstract: Efficient One-Pot Synthesis of Polysubstituted...

Uracil derivativesR 0520 DOI: 10.1002/chin.201149161

Efficient One-Pot Synthesis of Polysubstituted 6-[(1H-1,2,3-Triazol-1-yl)meth-yl]uracils Through the "Click" Protocol. — A variety of acyclic triazolo nucleoside analogues is synthesized utilizing Cu(I)-catalyzed azide—alkyne Huisgen "click" cy-cloaddition reactions. None of the prepared compounds exhibits any significant antivi-ral, antiproliferative or thymidine phosphorylase inhibitory activities. — (JANSA*, P.; SPACEK, P.; VOTRUBA, I.; BREHOVA, P.; DRACINSKY, M.; KLEPETAROVA, B.; JANEBA, Z.; Collect. Czech. Chem. Commun. 76 (2011) 9, 1121-1131, http://dx.doi.org/10.1135/cccc2011074 ; Inst. Org. Chem. Biochem., Acad. Sci. Czech Rep., CZ-166 10 Prague 6, Czech Republic; Eng.) — H. Toeppel

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ChemInform 2011, 42, issue 49 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim