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Cytochrome P450 2D6 Known Drug Interaction Chart
Drugs Metabolized by CYP2D6 Enzyme Drug Inhibitors of CYP2D6 Enzyme ANALGESICS CHOLINESTERASE INHIBITORS STRONG INHIBITORS OTHER KNOWN INHIBITORS:* codeine donepezil bupropion ANALGESICS hydrocodone cinacalcet celecoxib
oxycodone COUGH SUPPRESSANT fluoxetine methadone
phenacetin dextromethorphan paroxetine tramadol quinidine ANTIEMETIC/PROKINETICS PSYCHOTROPICS metoclopramide
ANESTHETICS amitriptyline MODERATE INHIBITORS lidocaine amphetamine duloxetine ANTIHISTAMINES aripiprazole sertraline chlorpheniramine
ANORECTICS atomoxetine terbinafine clemastine
dexfenfluramine chlorpromazine diphenhydramine
clomipramine WEAK INHIBITORS hydroxyzine
ANTIEMETIC/PROKINETICS desipramine amiodarone metoclopramide duloxetine cimetidine ANTINEOPLASTICS ondansetron fluoxetine doxorubicin
fluvoxamine ANTIHISTAMINES haloperidol ANTIRETROVIRAL, HIV
INHIBITORS chlorpheniramine iloperidone promethazine imipramine ritonavir
methamphetamine indinavir
ANTINEOPLASTICS methoxyamphetamine tamoxifen minaprine ANTITHROMBOTIC AGENTS nortriptyline ticlopidine
CARDIOVASCULAR paroxetine alprenolol perphenazine CARDIOVASCULAR
carvedilol pimozide midodrine clonidine risperidone debrisoquine sertraline HISTAMINE H2 ANTAGONIST,
ACID SUPPRESSANTS diltiazem thioridazine disopyramide venlafaxine ranitidine flecainide zuclopenthixol S-metoprolol PSYCHOTROPICS
mexiletine chlorpromazine
nebivolol citalopram
perhexiline clomipramine
propafenone cocaine
propranolol doxepin
sparteine escitalopram
timolol haloperidol
Drug Inducers of CYP2D6 Enzyme perphenazine
dexamethasone pimozide
rifampin thioridazine
*Extent of inhibition not well defined, degree of inhibition may vary. This chart is a partial listing of drugs known to affect CYP2D6 activity based on data from: 1. http://medicine.iupui.edu/clinpharm/ddis/table.aspx 2. http://www.pharmgkb.org/gene/PA128 3. FDA-approved drug information
Reviewed 08/2014
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