DEEP / SYSTEMIC MYCOSES

Dr. A.Aziz Djamal MSc.DTM&H.SpMK(K)

1. Cosmopolitant : Aspergillus, Candida and

Cryptococcosis.

2. Exotic type : In a specific area Penicillium

marneffei

A Group of Fungi that cause a variety of systemic / deep seated infection each ranging in severity from subclinical to progressive , debilitating diseases

Several Deep Mycoses :1.Aspergillus.2.Candida3.Cryptococcus4.Penicillicium marneffei.5.Coccidioides.6.Paracoccidioides.7.Mucormycoses.8.Paehypomycoses9.Blastomycoses.10.Pseudallescheriasis.11.Fusariosis

Common species : Aspergillus fumigatus Aspergillus flavus

1.Sinusitis : Unilateral,non-invasive, maxillary sinus.2.Pulmonary aspergilloma : Free and mobile Fungus ball in residual lung cavity/tb ,interwoven hyphae, haemoptysis.3.Invasive Pulmonary aspergillosis : With or Without Deep Lesion. Fatal opportunistic infection in certain group of netrophenia, extrapulmonary. AIDS.

1.Sinusitus aspergillus : Direct examination or histological biopsy examination.2. Pulmonary aspergilloma : Sputum culture. Precipitin specific to A. fumigatus or A. flavus3. Invasive Pulmonary Aspergillosis : Clinical outcome, Immune status and fungus isolation.

Only on Predisposed patient / Opportunistic. Local or systemic predisposing factors. Persoption not exogenous infection.

Causative Agent :Cryptococcus neoformans var. neoformans ( cosmopolitant) var gattii ( Exclusive in tropic )

Yeast : 4-6 micrometer characteristic capsule ext ; 25 micrometer. capsule : complex polysaccharide polymer Glucoronoxylomannan ( GXM)