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Continuing Medical Education examination
Diagnostic, functional, and therapeutic roles of microRNAin allergic diseases
Instructions for category 1 Continuing Medical Education credit
The American Academy of Allergy, Asthma & Immunology is accredited as a provider of Continuing Medical Education (CME) bythe Accreditation Council for Continuing Medical Education.
Test ID no.: mai00259Contact hours: 1.0Expiration date: June 30, 2014
Category 1 credit can be earned by reading the text material and taking this CME examination online. For complete instructions, visitthe Journal’s Web site at www.jacionline.org.
The Editors thank the University of South Florida Allergy/Immunology training program for developing this CME examination. Theindividuals who contributed to its preparation were Neetu Talreja, MD, Salman Aljubran,MD, GregoryM. Cowan,MD, Nauman Salim,MD, Susan Culverhouse, MD, and Roger W. Fox, MD, under the direction of Richard F. Lockey, MD.
Learning objectives: ‘‘Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases’’
1. To identify microRNA (miRNA) profiles involved in the pathogenesis of asthma, eosinophilic esophagitis, allergic rhinitis, andatopic dermatitis.
2. To understand the role of miRNAs in regulating eosinophils and their development.3. To identify perspectives for future investigation and clinical utility of miRNAs.
CME items
Question 1. Which signal transducer and activator of transcription(STAT) is targeted by miR-146a and suppresses TH1 responses?A. STAT1B. STAT3C. STAT4D. STAT6
Question 2. Which of the following cytokines is important for thedevelopment of eosinophil lineage?
A. IL-2B. IL-13C. IL-5D. IL-10
14 July 2013
Question 3. miR-223 acts on which of the following receptors tolimit eosinophil progenitor proliferation?
A. insulin-like growth factor 1 receptor (IGF1R)B. Fcε IgEC. CCR3D. TGF-b
Question 4. Which miRNA family member is associated withallergic asthma, eosinophilic esophagitis, and atopic dermatitis?
A. miR-155B. miR-365C. let-7cD. miR-187
Question 5. Which mechanism regulates miRNA expression?
A. reprogrammingB. DNA sequence length changesC. anticipationD. DNA methylation
J ALLERGY CLIN IMMUNOL
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