Differential Gene Expression

Differential Gene Differential Gene ExpressionExpression

Differential Gene Differential Gene TranscriptionTranscription

What are the major differences between What are the major differences between prokaryotic and eukaryotic genes?prokaryotic and eukaryotic genes?

Differential Gene Differential Gene TranscriptionTranscription

Differential Gene Differential Gene TranscriptionTranscription

Differential Gene Differential Gene TranscriptionTranscription

Differential Gene Differential Gene TranscriptionTranscription

PromotersPromoters

How do promoters How do promoters work?work?

EnhancerEnhancer

How is an enhancer different from a How is an enhancer different from a promoter?promoter? Activates use of promoterActivates use of promoter Activates promoters on same strandActivates promoters on same strand Doesn’t need to be adjacent to geneDoesn’t need to be adjacent to gene Doesn’t need to be upstreamDoesn’t need to be upstream

EnhancerEnhancer

How can one How can one identify presence identify presence of an enhancer?of an enhancer?

Why are they so Why are they so important?important?

Transcription FactorsTranscription Factors

What are the major structural What are the major structural domains of these molecules?domains of these molecules? DNA-binding domainDNA-binding domain Trans-activating domainTrans-activating domain Protein-protein interaction domainProtein-protein interaction domain

Transcription FactorsTranscription Factors

What is MITF?What is MITF?

DNADNA

DNA-binding domainDNA-binding domain

Protein-protein Protein-protein interaction domaininteraction domain

Trans-activating domainTrans-activating domain

Transcription FactorsTranscription Factors

Why is PAX6 such an important molecule?Why is PAX6 such an important molecule?

SilencersSilencers

What are silencers?What are silencers?

Transcriptional ControlTranscriptional Control

Of what value is Of what value is DNA methylation?DNA methylation?

How has this been How has this been demonstrated demonstrated experimentally?experimentally?

How does How does methylation work?methylation work?

Transcriptional ControlTranscriptional Control

What are insulators?What are insulators?

Transcriptional ControlTranscriptional Control

How does dosage How does dosage compensation compensation influence influence transcription?transcription?

What are Barr What are Barr bodies?bodies?

How does this relate How does this relate to calico cats?to calico cats?

RNA ProcessingRNA Processing

What is the difference between nRNA and What is the difference between nRNA and mRNA?mRNA?

RNA ProcessingRNA Processing

How is differential How is differential splicing of nRNA splicing of nRNA accomplished?accomplished?

What is the What is the difference between difference between genome and genome and proteome?proteome?

Translational ControlTranslational Control

What are some of the factors that influence What are some of the factors that influence gene expression at the level of translation?gene expression at the level of translation?

Translational ControlTranslational Control

Posttranslational RegulationPosttranslational Regulation

What is meant by this level of What is meant by this level of regulation?regulation?

How can it occur?How can it occur?

Controlling Gene ExpressionControlling Gene Expression

Controlling Gene ExpressionControlling Gene Expression

Controlling Gene ExpressionControlling Gene Expression