Hb synthesis

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Pathway for the synthesis of hemoglobin molecule, simplified

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SYNTHETIC PATHWAY OF HAEMOGLOBIN

GLYCINE+PUIDOXAL PO4

AMINOLAEVULINIC ACID

COPROPORPHYRINOGEN III

GSH

ACETATE SUCCINATE SUCCINYL CoAKreb’s Cycle CoA Mg++ ATP

(ALA)PORPHOBILINOGEN

ALA-DH

GSH

UROPORPHYRINOGEN I

COPROPORPHYRINOGEN

PDUS

UROPORRPHYRINOGEN III

PDUS

PROTOPORPHYRIN IX Fe++ + GLOBIN HAEMOGLOBINF-CH HS+

ALA-S

ALA-S : Synthetase ALA-DH : DehydratasePD : Deaminase US : SynthetaseUD : Decarboxylase UO : OxidaseF-CH : Ferrochelatase HS : Haemoglobin SynthetaseGSH : Reduced Glutathione

Hb synthesis

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