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Lecture VII. CNS Patterning. Bio 3411 Wednesday September 16, 2009. T. Woolsey 3802 North Building 362-3601 woolseyt@medicine.wustl.edu. Reading. THE BRAIN ATLAS: p 10. Selected References:. - PowerPoint PPT Presentation
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Lecture VII. CNS Patterning
Bio 3411 Wednesday
September 16, 2009
• T. Woolsey
• 3802 North Building
• 362-3601
• woolseyt@medicine.wustl.edu
2Lecture VII. CNS PatterningSeptember 16, 2009
Reading
THE BRAIN ATLAS: p 10
3Lecture VII. CNS PatterningSeptember 16, 2009
September 16, 2009 Lecture VII. CNS Patterning 4
Selected References:
† Benito-Gutierrez, E., & Arendt, D. (2009). CNS evolution: new insight from the mud. Curr Biol, 19(15), R640-642.
Hamilton, W. J., Boyd, J. D., & Mossman, H. W. (1972). Hamilton, Boyd and Mossman's human embryology; prenatal development of form and function (4th ed.). Cambridge,: Heffer.†Hartenstein, V. (1993). Atlas of Drosophila Development.
Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of neural science (4th ed.). New York: McGraw-Hill, Health Professions Division.
Chapter 52, pp 1019-1040.†Puelles, L. (2009). Forebrain Development: Prosomere Model. in: New Encyclopedia of Neuroscience. Amsterdam: Elsevier.
Ranson, S. W., & Clark, S. L. (1959). The anatomy of the nervous system; its development and function (10th ed.). Philadelphia,: Saunders.––––––––––––––
† Posted on web site.
What the last Lecture was about
• General mechanisms for assembling neurons and groups of neurons
• Diffusion vs Contact
• Attraction vs Repulsion
• Examples of impacts of contact
• Examples of impacts of diffusion
• Specification by growth factors
• The chemoaffinity hypothesis
September 16, 2009 Lecture VII. CNS Patterning 5
What this Lecture is about
September 16, 2009 Lecture VII. CNS Patterning 6
• The Initiation of the Central Nervous System
• CNS Growth and Pattern Development
• Bug Brains
• Several Mechanisms for Directing the Show (scripts conserved)
• How did vertebrate and invertebrate patterns arise?
September 16, 2009 7Lecture VII. CNS Patterning
Recap of Early Embryogenesis
September 16, 2009 8Lecture VII. CNS Patterning
Ranson & Clark (1959)
September 16, 2009 9Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 16, 2009 10Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 16, 2009 11Lecture VII. CNS Patterning
From Tube to Brain
September 16, 2009 12Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 16, 2009 Lecture VII. CNS Patterning 13
THE BRAIN ATLAS 3rded, p.10
September 16, 2009 Lecture VII. CNS Patterning 14
Hamilton, Boyd, & Mossman (1972)
September 16, 2009 Lecture VII. CNS Patterning 15
Hamilton, Boyd, & Mossman (1972)
September 16, 2009 Lecture VII. CNS Patterning 16
Hamilton, Boyd, & Mossman (1972)
September 16, 2009 Lecture VII. CNS Patterning 17
Hamilton, Boyd, & Mossman (1972)
September 16, 2009 Lecture VII. CNS Patterning 18
Hamilton, Boyd, & Mossman (1972)
September 16, 2009 Lecture VII. CNS Patterning 19
Hamilton, Boyd, & Mossman (1972)
September 16, 2009 Lecture VII. CNS Patterning 20
From Fly Egg to Fly Brain
September 16, 2009 21Lecture VII. CNS Patterning
Hartenstein (1993)
September 16, 2009 22Lecture VII. CNS Patterning
Hartenstein (1993)
September 16, 2009 23Lecture VII. CNS Patterning
Hartenstein (1993)
September 16, 2009 24Lecture VII. CNS Patterning
Hartenstein (1993)
September 16, 2009 Lecture VII. CNS Patterning 25
Segmentation and Signals
September 16, 2009 26Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 16, 2009 27Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 16, 2009 28Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 16, 2009 29Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
30September 16, 2009 Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 16, 2009 Lecture VII. CNS Patterning 31
Kandel, Schwartz, & Jessell (2000)
September 16, 2009 32Lecture VII. CNS Patterning
Ancient Choice?
September 16, 2009 Lecture VII. CNS Patterning 33
Benito-Gutierrez & Arendt, (2009)
September 16, 2009 34Lecture VII. CNS Patterning
Benito-Gutierrez & Arendt, (2009)
What this Lecture was about
September 16, 2009 Lecture VII. CNS Patterning 35
• The Initiation of the Central Nervous System
• CNS Growth and Pattern Development
• Bug Brains
• Several Mechanisms for Directing the Show (scripts conserved)
• How did vertebrate and invertebrate patterns arise?
Reflections
• Early events initiating the nervous system
• Beginning the sculpture – proliferation and death mechanisms
• Signals for functional and connectional specificity – contact, distance, for or against
• The pattern and organization emerges
• Generalizations made but questions unanswered
September 16, 2009 Lecture VII. CNS Patterning 36
Sequential Restrictions (Refinements) are the Bases for Development (and plasticity)
September 16, 2009 37Lecture VII. CNS Patterning
pluripotent, stem cell
differentiated
genetic
environmental
September 16, 2009 Lecture VII. CNS Patterning 38
September 16, 2009 Lecture VII. CNS Patterning 39
http://embryo.soad.umich.edu/
September 16, 2009 Lecture VII. CNS Patterning 40
Finis
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