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Lecture VII. CNS Patterning3 Selected References: † Benito-Gutierrez, E., & Arendt, D. (2009). CNS evolution: new insight from the mud. Curr Biol, 19(15), R Hamilton, W. J., Boyd, J. D., & Mossman, H. W. (1972). Hamilton, Boyd and Mossman's human embryology; prenatal development of form and function (4th ed.). Cambridge,: Heffer. † Hartenstein, V. (1993). Atlas of Drosophila Development. Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of neural science (4th ed.). New York: McGraw-Hill, Health Professions Division. Chapter 52, pp † Puelles, L. (2009). Forebrain Development: Prosomere Model. in: New Encyclopedia of Neuroscience. Amsterdam: Elsevier. Ranson, S. W., & Clark, S. L. (1959). The anatomy of the nervous system; its development and function (10 th ed.). Philadelphia,: Saunders. –––––––––––––– † (pdfs on course websites: [http://artsci.wustl.edu/~bio3411/] & [http://www.nslc.wustl.edu/courses/Bio3411/bio3411.html]
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Lecture VII. CNS Patterning
Bio 3411 Wednesday
September 22, 2010
September 22, 2010 1Lecture VII. CNS Patterning
Reading
THE BRAIN ATLAS: p 10
2Lecture VII. CNS PatterningSeptember 22, 2010
September 22, 2010 Lecture VII. CNS Patterning 3
Selected References:
† Benito-Gutierrez, E., & Arendt, D. (2009). CNS evolution: new insight from the mud. Curr Biol, 19(15), R640-642.Hamilton, W. J., Boyd, J. D., & Mossman, H. W. (1972). Hamilton, Boyd and Mossman's human embryology; prenatal development of form and function (4th ed.). Cambridge,: Heffer.†Hartenstein, V. (1993). Atlas of Drosophila Development.Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of neural science (4th ed.). New York: McGraw-Hill, Health Professions Division.Chapter 52, pp 1019-1040.†Puelles, L. (2009). Forebrain Development: Prosomere Model. in: New Encyclopedia of Neuroscience. Amsterdam: Elsevier.Ranson, S. W., & Clark, S. L. (1959). The anatomy of the nervous system; its development and function (10th ed.). Philadelphia,: Saunders.––––––––––––––
†(pdfs on course websites: [http://artsci.wustl.edu/~bio3411/] & [http://www.nslc.wustl.edu/courses/Bio3411/bio3411.html]
What the last Lecture was about
• General mechanisms for assembling neurons and groups of neurons
• Diffusion vs Contact
• Attraction vs Repulsion
• Examples of impacts of contact
• Examples of impacts of diffusion
• Specification by growth factors
• The chemoaffinity hypothesis
September 22, 2010 Lecture VII. CNS Patterning 4
What this Lecture is about
September 22, 2010 Lecture VII. CNS Patterning 5
• The Initiation of the Central Nervous System
• CNS Growth and Pattern Development
• Bug Brains
• Several Mechanisms for Directing the Show (scripts conserved)
• How did vertebrate and invertebrate patterns arise?
September 22, 2010 6Lecture VII. CNS Patterning
Recap of Early Embryogenesis
September 22, 2010 7Lecture VII. CNS Patterning
Ranson & Clark (1959)
September 22, 2010 8Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 22, 2010 9Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 22, 2010 10Lecture VII. CNS Patterning
From Tube to Brain
September 22, 2010 11Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 22, 2010 Lecture VII. CNS Patterning 12
THE BRAIN ATLAS 3rded, p.10
September 22, 2010 Lecture VII. CNS Patterning 13
Hamilton, Boyd, & Mossman (1972)
September 22, 2010 Lecture VII. CNS Patterning 14
Hamilton, Boyd, & Mossman (1972)
September 22, 2010 Lecture VII. CNS Patterning 15
Hamilton, Boyd, & Mossman (1972)
September 22, 2010 Lecture VII. CNS Patterning 16
Hamilton, Boyd, & Mossman (1972)
September 22, 2010 Lecture VII. CNS Patterning 17
Hamilton, Boyd, & Mossman (1972)
September 22, 2010 Lecture VII. CNS Patterning 18
Hamilton, Boyd, & Mossman (1972)
September 22, 2010 Lecture VII. CNS Patterning 19
From Fly Egg to Fly Brain
September 22, 2010 20Lecture VII. CNS Patterning
Hartenstein (1993)
September 22, 2010 21Lecture VII. CNS Patterning
Hartenstein (1993)
September 22, 2010 22Lecture VII. CNS Patterning
Hartenstein (1993)
September 22, 2010 23Lecture VII. CNS Patterning
Hartenstein (1993)
September 22, 2010 Lecture VII. CNS Patterning 24
Segmentation and Signals
September 22, 2010 25Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 22, 2010 26Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 22, 2010 27Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 22, 2010 28Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
29September 22, 2010 Lecture VII. CNS Patterning
Kandel, Schwartz, & Jessell (2000)
September 22, 2010 Lecture VII. CNS Patterning 30
Kandel, Schwartz, & Jessell (2000)
September 22, 2010 31Lecture VII. CNS Patterning
Ancient Choice?
September 22, 2010 Lecture VII. CNS Patterning 32
Benito-Gutierrez & Arendt, (2009)
September 22, 2010 33Lecture VII. CNS Patterning
Benito-Gutierrez & Arendt, (2009)
What this Lecture was about
September 22, 2010 Lecture VII. CNS Patterning 34
• The Initiation of the Central Nervous System
• CNS Growth and Pattern Development
• Bug Brains
• Several Mechanisms for Directing the Show (scripts conserved)
• How did vertebrate and invertebrate patterns arise?
Reflections
• Early events initiating the nervous system
• Beginning the sculpture – proliferation and death mechanisms
• Signals for functional and connectional specificity – contact, distance, for or against
• The pattern and organization emerges
• Generalizations made but questions unanswered
September 22, 2010 Lecture VII. CNS Patterning 35
Sequential Restrictions (Refinements) are the Bases for Development (and plasticity)
September 22, 2010 36Lecture VII. CNS Patterning
pluripotent, stem cell
differentiated
genetic
environmental
September 22, 2010 Lecture VII. CNS Patterning 37
September 22, 2010 Lecture VII. CNS Patterning 38
http://embryo.soad.umich.edu/
September 22, 2010 Lecture VII. CNS Patterning 39
Finis
