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Metabolic Syndrome: Focused on AMPK as Molecular Target for Metabolic Syndrome. Bayu Lestari. What will be Impaired in This Patient?. Insulin Resistance?. Dyslipidemia? (High TG, High LDL, Low LDL). T2DM?. Metabolic Syndrome. Obese. Background. - PowerPoint PPT Presentation
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Metabolic Syndrome: Focused on AMPK as Molecular Target for
Metabolic SyndromeBayu Lestari
What will be Impaired in This Patient?
Obese
Insulin Resistance?
Dyslipidemia? (High TG, High LDL, Low LDL)
T2DM?
Metabolic Syndrome
High prevalence of metabolic syndrome: relation between glucose and lipid metabolism
Various clinical manifestations: T2DM, obese, dyslipidemia
New therapeutic approach required for efficient and high efficacy
AMPK was reported as potent molecular target for metabolic syndrome therapy
Background
Discuss about Metabolic Syndrome Discuss about AMPK as molecular target for
therapy
Aim
Cluster of syndrome: insulin resistance, high blood glucose, dyslipidemia, obese
Impairment both glucose metabolism and lipid metabolism
Correlation between glucose and lipid metabolism?
Metabolic Syndrome
Glucose Transport and How Insulin Resistance Occur
How Lipid Disorder Affect Insulin Resistance
Structure of AMPK
Activation Pathway of AMPK
Regulation of AMPK
How AMPK Activation Reduce Metabolic Syndrome
Enhanced translocation of GLUT4 Enhanced expression of GLUT4 gene (Zheng
et al, 2009) Insulin independent pathway?
Role AMPK on GLUT4
mTOR Pathway
Insulin-mTOR pathway activation & phosphorylation S6 kinase I, down-regulation insulin receptor substrate-1 (IRS1) decrease insulin signalling (Zheng et al, 2009)
Role AMPK in Insulin Sensitivity
AMPK activation improve mitochondrial function via expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator-1α (PGC-1α) reduce insulin resistance reduce development of T2DM (Zheng et al, 2009)
Role AMPK in Mitochondrial Biogenesis
Role AMPK in Lipid Metabolism
Lipid Oxidation Lipogenesis
Metabolic syndrome: cluster of syndromes (insulin resistance, dyslipidemia, obese)
AMPK has beneficial role as molecular target for metabolic syndrome’s therapy
Conclusion
Thank You
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