PECULIAR COMPLICATIONS OF VITREORETINA SURGERY IN SUBSAHARAN AFRICA Olufemi Oderinlo FRCSEd,FWACS,...
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- PECULIAR COMPLICATIONS OF VITREORETINA SURGERY IN SUBSAHARAN
AFRICA Olufemi Oderinlo FRCSEd,FWACS, DRCOphth. Consultant
Ophthalmologist and Vitreoretina Surgeon EYE FOUNDATION HOSPITAL
GROUP
- Slide 2
- FINANCIAL DISCLOSURE: NO FINANCIAL INTEREST IN MATERIAL
PRESENTED
- Slide 3
- INTRODUCTION Sub-Saharan Africa contains less than 10% of the
worlds population, but 20% of the worlds blind. 1 ophthalmologist
per million population African studies confirm patients with VR
diseases present late and with complex pathologies. 25 -40 % of RDs
have advanced PVR of > grade C-1 at presentation Frequent only
eye presentations, sickle cell retinopathy, complications of PDR,
complications of trauma from regional conflicts Prolonged surgery
and less satisfactory visual outcome
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- Complications of VR surgery in2010 FrequencyPercent Cataract
1111.0 Elevated IOP 88.0 Hyphaema 22.0 Band keratopathy 22.0
Rubeosis 22.0 Hyperoleum 11.0 Subretina fluid 11.0 Ant staphyloma
11.0 No post operative complicaction 7272.0
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- Timing of complication FrequencyPercent Immediate (first 3
days) 13.7 Early (4 days to 6 weeks) 1140.7 Late (more than 6
weeks) 1555.6
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- Cataract Incidence btw 50 and 95% Mechanism unclear :
antioxidant function of vitreous, pre-existing cataract, advancing
age, light toxicity from the operating microscope, diabetes, use of
intraocular gas or silicone oil, and trauma to lens. duration of
vitrectomy does not increase the risk.
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- Elevated IOP/ Glaucoma Incidence 6 8% Gas : improper mixture,
better to do mixture your self, pupil block. Acute elevation
Silicon oil (Chronically elevated IOP was more prevalent in
silicone oil eyes than in C3F8 gas eyes) Silicon Study Ghost cell :
intavitreal bevacizumab and vitrectomy. Aim to reduce inflammation
and IOP, paracentesis may be helpful Inflammatory: trabeculitis.
Steroid induced
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- Silicon oil and IOP Overfill of vitreous cavity Emulsification
(Incidence equal for 1000cs and 5000cs), Hyperoleum. Pupil block :
absent andoiridectomy in aphakia, closed iridectomy from fibrosis
may require reopening andoiridotomy (Yag) or sugical or oil
exchange
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- Cataract + pupil block
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- Silicon oil complications Changes in refractive status :4 TO 8D
change keratopathy: Punctate epithelial changes, cornea epithelial
defect, band keratopathy are all reported The Silicone Study was
the first study to document that the postoperative incidence rates
of corneal abnormalities are equivalent between oil and gas.
Popovic SS, Sikic J, Pokupec R. Intraocular pressure values
following vitrectomy with silicone oil tamponade. Acta Med
Croatica. 2005; 59: 143-6. 6. Quintyn JC, Genevois O, Ranty ML, et
al. Silicone oil migration in the eyelid after vitrectomy for
retinal detachment. Am J Ophthalmol. 2003; 136: 540-2.
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- Cornea complications Silicon oil Keratopathy Light microscopy :
increased cellularity and irregularity of collagen fibers of
stroma. Endothelium degeneration with some oil droplets noted More
likely due to barrier effects of silicon than direct toxicity
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- Subretina silicon oil Rare complication Can cause redetachment
or migrate with time. Reduces visual function. Usually requires
reoperation, retinotomy, relieve residual traction.
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- Optic chiasmal and brain migration of silicon oil are reported
(case reports).
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- Retained subretina PFCL retina toxicity may occur from retained
perflourocarbon liquids as well as scotomata and elevated
intraocular pressures If very small bubble may be ignored but large
bubbles shoud be removed.
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- Hemorrhage Vitreous Retina Suprachoroidal Hyphema
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- Inflammation Severe inflammation is rare Excessive retinopexy
esp. cryo, repeat surgery. Periocular and systemic steroids
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- Endophthalmitis An incidence of between 0.023% and 0.039% is
reported, with staphylococcus aureus more often involved. A recent
large series study reported no difference in incidence of End.
after 20G and 23G vitrectomy. Parolini B, Romanelli F, Prigione G,
Pertile G. Incidence of endophthalmitis in a large series of 23-
gague and 20-gague transconjuntival pars plana vitrectomy. Graefes
Arch Clin Exp Ophthalmol. 2009;247:8958. [PubMed]PubMed
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- Endophthalmitis Outcomes are usually poor with greater than 67%
having NPL vision. organisms other than coagulase-negative
staphylococci tend to have poor visual prognosis. EVS results used
as guide only Systemic antibiotics (fourth generation
flouroquinolones ), Intravitreal antibiotics (vancomycin,
ceftazidime, amikacin) silicon oil exchange. intravitreal
quinupristin/dalfopristin Q/D( recently developed streptogramin
antibiotic in 3/7 combination ratio) Am J Ophthalmol.Am J
Ophthalmol. 2004 Nov;138(5):799-802. Endophthalmitis after pars
plana vitrectomy: Incidence, causative organisms, and visual acuity
outcomes. Eifrig CWEifrig CW, Scott IU, Flynn HW Jr, Smiddy WE,
Newton JScott IUFlynn HW JrSmiddy WENewton J
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- Iatrogenic retina breaks Incidence 1-2% Peeling highly adherent
ERM, PVR membranes Insertion and removal of instruments from the
eye can cause peripheral retina breaks. Maximize use of each
instrument before removal Remove peripheral vitreous as much as
possible before instruments
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- Wound leaks and hypotony Advent of small gauge vitrectomy
raised some concern about wound leaks Avoiding complications such
as wound leak, hypotony, choroidal detachment and endophthalmitis
through optimal surgical technique is critical. Proper wound
construction and closure are both necessary to ensure tight
self-sealing wounds.
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- Partial or complete air-fluid exchange, thorough peripheral
vitrectomy, and subconjunctival antibiotics are supplemental steps
that may also help ensure successful surgical outcomes Other
factors that contribute to wound leakage, such as increased
surgical duration and nonmacular diagnosis, may be indirect
measurements of extensive trocar rotation, causing wound
leakage.
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- CHRONIC HYPOTONY Chronic hypotony was more prevalent in C3F8
gas eyes than in silicone oil eyes. (The silicon study) ?
Retinectomy
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- Retina toxicity from ICG, Aminoglycosides and fiberoptic light
are reported Phototoxic lesions caused by the endoilluminator are
similar to lesions caused by the operating microscope but are
usually larger in size and have less well-delineated borders. The
wavelength of light used, the power of the light source and the
duration of use determine the amount of ocular damage in
phototoxicity.
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- Aminoglycoside toxicity Can cause acute, toxic ischaemic
retinopathy Severe retina vasc occlusion and optic neuropathy.
Prevention is crucial.
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- Scleral buckle Retina hemorrhage from drainage of subretina
fluid. Drainage safer on both sides of horizontal recti and highest
level of subretina fluid.
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- Extrusion of buckle Incidence 3.5 to 24% with silicon sponge
Incidence0.6 to 1.2% with solid silicon
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- Anisometropia Increase in axial length Lens can become thicker
and displaced anteriorly 2 3 D myopic shift Cornea steepening
leading to astigmatism
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- Strabismus Incidence 3 30% Exotropia, esotropia, hypertropia
and cyclotorsional changes Many times removal of buckle does not
resolve deviation MRI of orbit useful Squint surgery may be
required
- Slide 30
- Generally complication rates after vitreoretina surgery is low
and most can be prevented by paying attention to detail and being
meticulous.
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- THANK YOU
- Slide 32
- REFERENCES Foos RY, Simons KB, Wheeler NC. Comparison of
lesions predisposing to rhegmatogenous retinal detachment by race
of subjects. Am J Ophthalmol 1983; 96: 644649 D Yorston and S
Jalali.Retinal detachment in developing countries Eye (2002) 16,
353358. doi: 10.1038/sj.eye.6700188
- Slide 33
- Lin, Albert L B; Ghate, Deepta A ; Robertson, Zachary M ;
O'sullivan, Patrick Sean ; May, Warren L ; Chen, Ching-Jygh Factors
Affecting Wound Leakage in 23-Gauge Sutureless Pars Plana
Vitrectomy Retina: June 2011 - Volume 31 - Issue 6 - pp
1101-1108