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Principles of Immunology
The Inflammatory Process4/6/06
"Life is not measured by the number of breaths we take, but by those special moments that take our breath away."
Anonymous
Word/Terms List
Acute phase proteins Cell adhesion molecules Chemotaxis HEVs ICAMs Integrins Mucins Selectins
Inflammatory Process
A localized tissue responseTriggered by trauma and/or antigenic insultMay include systemic effectsCharacterized by redness, heat, swelling, and painPrincipal cells are leukocytes and macrophages
Cell Adhesion Molecules (CAMs)
Required for extravasation
Neutrophil extravasation
Lymphocyte extravasation
Cell Adhesion Molecules (CAMs) Selectins
Glycoproteins Bind to carbohydrates Expressed on leukocytes and endothelial cells
Mucins Proteins Present CHO ligands to selectins Present on endothelial cells and neutrophils
Integrins Proteins; heterodimers Expressed on leukocytes Bind to Ig superfamily molecules
ICAMs Ig CAMs Expressed on endothelial cells Bind to integrins
Overview of Inflammation Cells involved
Monocytes/macrophages Neutrophils
Mediators Histamine Cytokines Kinins
Vascular changes Dilation Increased permeability
Complement
Effects of Macrophage Cytokines
IL-1, IL-6, TNF alpha Pyrogenic Vascular permeability Expression of CAMs T and B cell activation Ig synthesis
Interferon Effects
T Helper induction Macrophage activation MHC expression NK cytotoxicity B cell activation
Lymphocyte Extravasation
Naïve lymphocytes Occurs in secondary lymphoid organs Occurs in high endothelial venules
(HEVs) Lymphocte homing
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