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Research Journal of
Chemistry and Environment
Vol. 22 (Special Issue II), August 2018
E-ISSN: 2278 - 4527 ! PRINT-ISSN No. 0972 - 0626
Journal is indexed in SCOPUS andChemical Abstracts
ii
GOD IS.
E-ISSN: 2278 – 4527 PRINT-ISSN No. 0972-0626
RESEARCH JOURNAL OF CHEMISTRY AND ENVIRONMENT
An International Research Journal of Chemical Sciences and Environmental Sciences
Res. J. Chem. Environ., Volume 22(Special Issue II), Pages 1-350, August (2018)
Editor- in- Chief (Hon.)
Dr. D.K. Vardhan Mumbai, INDIA
Correspondence Address:
Research Journal of Chemistry and Environment
Sector AG/80, Scheme No. 54, Indore 452 010 (M.P.) INDIA
Phone and Fax: +91-731-4004000
Website: https://worldresearchersassociations.com
E-mail: info@worldresearchersassociations.com
CONTENTS
Research Papers:
1. Biosynthesis of Silver Nanoparticles using Jicama Extract and Its Application for Colorimetric
Sensing of Mercury Ions
- Firdaus M. Lutfi, Megarani Juwita, Purawiardi R. Ibrahim, Eddy Diana Rakhmawaty and Rahayu Iman
1-3
2. Synthesis and Structural Analysis of Aurivillius Phase, Ca1-xBi3+xNdTi4-xMnxO15
- Zulhadjri, Bilian Sahiga J.I., Wendari Tio Putra and Emriadi
4-9
3. Digital-Based Image Detection System in Simple Silver Nanoparticles-based Cyanide Assays
- Tambaru David, Nomi Anastasia Grandivoriana and Nitti Fidelis
10-14
4. Preparation of Mixed Matrix Polymeric Membrane for removing of contaminants in Crude Biodiesel
- Saiful, Ramli Muliadi, Maulana Ilham, Fadli and Yusuf M.
15-21
5. A new zinc (II) responsive MRI contrast agent
- Adhitiyawarman and Mark P. Lowe
22-30
6. Synthesis of Benzyl-Protected Robtein (2,3,4,4,5-Pentahydroxychalcone) as an Intermediate to (–)-
Robidanol
- Suharti, Achmadi Suminar S., Irfana Luthfan, Sugita Purwantiningsih, Wukirsari Tuti, Ilmiawati Auliya
and Arifin Budi
31-38
7. Antibacterial and antioxidant activities of pyrogallol and synthetic pyrogallol dimer
- Cynthia, Ignatia Florence, Sutanto Hery and Darmawan Akhmad
39-47
8. Preparation and Characterization of Titania/Bentonite Composite Application on the Degradation of
Naphthol Blue Black Dye
- Lubis Surya, Sheilatina, Putra Vicky Praja and Nika Syahrinta Sepia
48-53
9. Optimization of Light Exposure on Superoxide Scavenger Test of Manganese (III)-Salen Acetate
Complex - Nurrahmajanti Asiyah, Onggo Djulia and Deawati Yusi
54-57
10. Application of Molecularly Imprinted Polymer Technique on Chitosan Membranes for Increasing
Creatinine Transport Effectiveness
- Eka Sulistyaningsih
58-64
11. Total Phenolic and Flavonoid Contents and Antimicrobial activity of Acorus calamus L. Rhizome
Ethanol Extract
- Rita Wiwik Susanah, Kawuri Retno and Swantara I. Made Dira
65-70
iii
12. Optimization of process parameters for inulinase production from endophytic fungi Fusarium solani
LBKURCC67, Humicola fuscoatra LBKURCC68 and Fusarium oxysporum LBKURCC69
- Devi Silvera, Illiyin Luthfin, Ardhi Aulia, Pratiwi Nova Wahyu and Saryono
71-78
13. Morphological identification and hydrolytic enzyme-producing abilities of fungi associated with
wilting banana plants (Musa sp.)
- Saryono, Piska Finna, Sari Nurmala, Pratiwi Nova Wahyu and Ardhi Aulia
79-86
14. 20-Epibryonolic Acid from Tetrameles nudiflora Leaves
- Darmawan Akhmad, Fajriah Sofa, Megawati and Lotulung Puspa Dewi N.
87-90
15. Synthesis of fluorescent compound, 7-Hydroxy-4-methyl-2H-chroman-2-one via Pechmann
condensation of citric acid and resorcinol
- Al Anshori Jamaludin, Rahayu Diah Siti, Hidayat Ace Tatang, Hidayat Ika Wiani and Zainuddin Achmad
91-96
16. Distinguishing of Oligosaccharide Linkage Isomers by Nanoparticle-assisted Fragmentation in
MALDI-TOF MS
- Primadona Indah, Dedi, Wang Yi-Sheng and Chen Yu-Ju
97-101
17. Recombinant Anti BNP-SCFV Production in Escherichia coli and its Application for the Detection of
Heart Failure by Electrochemical Immunosensor using Screen-Printed Carbon Electrode-Gold
Nanoparticles (SPCE-GNP)
- Gaffar Shabarni, Hartati Yeni Wahyuni, Susanti Rini and Subroto Toto
102-107
18. Chemical Compositions of Banana Peels (Musa sapientum) Fruits cultivated in Malaysia using
proximate analysis
- Hassan Pyar and Peh K.K.
108-113
19. Isolation and Identification of Quercetin Derivatives and their -Glucosidase Inhibitory Acitivities
from Bryophyllum pinnatum
- Fajriah Sofa, Darmawan Akhmad, Megawati Megawati and Hanafi Muhammad
114-119
20. Influence of synthesis time on Lanthanum Silicate Apatite (La9.33Si6O26) properties
- Noviyanti Atiek Rostika, Juliandri, Agustina Shofia Utari and Malik Yoga Trianzar
120-123
21. A comparison of the fermentation performance and stress tolerance of baker’s yeast cells grown in
media with or without magnesium addition
- Rachman Saadah D., Hidayat Risma W., Safari Agus and Ishmayana Safri
124-128
22. Investigating Aluminasilicate Source in Geopolymer Compressive Strength: Surface Morphology and
Crystal Phase Study
- Anggarini Ufafa and Sukmana Ndaru Candra
129-133
23.
Optimization Density of Geopolymer Concrete based on Taguchi Method
- Sukmana Ndaru Candra, Pambudi Andry Agung and Anggarini Ufafa
134-138
24. Synthesis of 5-(4’-Chlorobenzylidene) hydantoin and N-3 Substituted 5-(4’-Chlorobenzylidene)-3-
Methylhydantoin
- Naufal Muhammad, Hamdani Ulfi Dadan, Maharani Rani, Al Anshori Jamaludin and Hidayat Ika Wiani
139-145
25. In vitro antioxidant activity of Sonneratia ovata Backer extract
- Khumaidah Laili, Nurmalasari Fatati, Putri Fatmawati Inneke, Purnomo Adi Setyo, Santoso Mardi,
Ersam Taslim and Fatmawati Sri
146-150
26. Effects of bacterium Ralstonia pickettii addition on DDT biodegradation by Daedalea dickinsii
- Purnomo Adi Setyo, Rizqi Hamdan Dwi, Fatmawati Sri, Putro Herdayanto Sulistyo and Kamei Ichiro
151-156
iv
27. The effect of Calcination Temperature of Sulfated Zirconia Catalyst for Simultaneous Reactions in
Biodiesel Production
- Andrijanto Eko and Brown Rob
157-162
28. Synthesis of Zirconia 1-D Nanomaterials from Local Zircon-Based Zr(OH)4 mediated by PEG-6000
- Septawendar Rifki, Nuruddin Ahmad, Maryani Eneng, Sutardi Suhanda and Purwasasmita Bambang
Sunendar
163-171
29. Effects of the Precipitation pH of Sodium Silicate on the Amorphous Silica Characteristics and its
capability in the Pb and Cd Adsorption
- Maryani Eneng, Septawendar Rifki and Suhanda
172-178
30. Critical Parameters of Silver Nanoparticles (AgNPs) synthesized by Sodium Borohydride Reduction
- Sholikhah Umi Nur, Pujiyanto Anung, Lestari Enny, Sarmini Endang, Lubis Hotman, Widyaningrum
Triani and Febriana Siska
179-183
31. Antibacterial Activity of Prenylated Xanthones from Pericarp of Garcinia mangostana against
Persistent Dental Infection Microorganism Enterococcus faecalis
- Setiawan Arlette Suzy, Herawati Mieke, Dewi Warta and Supratman Unang
184-188
32. Identification of a DNA Polymerase I Gene Fragment from a Local Isolate (PLS 80) from an
Underwater Hot Spring
- Febriani, Helwati H., Velayati M.A. and Iqbalsyah T.M.
189-192
33. Biohydrogen Production through Separate Hydrolysis and Fermentation and Simultaneous
Saccharification and Fermentation of Empty Fruit Bunch of Palm Oil
- Kusmardini Diah, Prasetyo Joni, Saepudin Endang and Hudiyono Sumi
193-197
34. Study Cytotoxicity of Haarlem Oil by Crystal Violet Staining Assay
- Khairan Khairan, Jamier Vincent and Jacob Claus
198-202
35. Determination of Optimum Pressure for Gd3+ Separation from Gd-DTPA with Nanofiltration
Membrane
- Rahayu Iman, Winanti Anti, Juliandri, Noviyanti Atiek Rostika, Eddy Diana Rakhmawaty, Anggraeni Anni
and Bahti Husein H.
203-205
36. Cytotoxic Effects of Cassava (Manihot esculenta Crantz), Adira-2, Karikil and Sao Pedro Petro
Varieties against P-388 Murine Leukemia Cells
- Widiastuti Diana, Mulyati Ade Heri, Eka Herlina, Siti Warnasih, Suchyadi Yudhie, Triastinurmiatiningsih
and Supratman Unang
206-208
37. Coating of Nanotube Ti-6Al-4V Alloy with Hydroxyapatite-Chitosan Composite by Electrophoretic
Deposition Method
- Charlena, Suparto Irma Herawati and Puspitawati Tuti
209-213
38. pH Effect of Gold Nanoparticles Synthesis Encapsulation in Polyamide Amine Generation 3.0
(AuNP-PAMAM G3.0)
- Pujiyanto Anung, Lestari Enny, Kurniasih Dede, Mujinah, Sholikhah Umi Nur, Gunawan Adang Hardi,
Amalia Sarah S. and Mutalib Abdul
214-219
39. Mode of action of an insecticidal oleanane glycoside on digestive enzymes of Crocidolomia pavonana
- Maharani Rani, Rizqiani Anggun Fuji, Ishmayana Safri, Hidayat Yusup and Dono Danar
220-225
40. Comparative assessment of yeast fermentation performance, ethanol tolerance and membrane fluidity
- Ishmayana Safri, Kennedy Ursula J. and Learmonth Robert P.
226-235
v
41. Preparation of ZnO/SiO2 Composite using Silica isolated from Rice Husk
- Eddy Diana Rakhmawaty, Ishmayana Safri, Noviyanti Atiek Rostika and Wahyuni Astri
236-239
42. Separation of Radioisotope Iodine-131 from Radiotellurium-131 using Dowex-1x8 resin column
chromatography
- Setiawan Duyeh, Nugraha Nabil Aulia and Hastiawan Iwan
240-244
43. Prelimimary Study of using Palm Oil Mill Effluent to produce Bio Hydrogen as Biofuel
- Prasetyo Joni, Febijanto Irhan, Murti S.D. Sumbogo and Dewi Eniya L.
245-248
44. Analysis and Characterization of Complex Compound Gadolinium-(1,4,7,10-Tetraazacyclododecane,
1-4-7-10-Tetraacetic Acid)n-Poliamidoamine Generation 3-Trastuzumab as a Novel Contrast Agent
for Magnetic Resonance Imaging
- Kusuma Yenni Nugraha Wira, Mutalib Abdul, Anggraeni Anni, Ramli Martalena, Fauzia Retna Putri and
Bahti Husein H.
249-254
45. Comparison of Different Methods for Purification of Gold Nanoparticles– Polyamidoamine
(PAMAM) Generation 4 Dendrimer
- Narsa Angga Cipta, Pujiyanto Anung, Gunawan Adang H., Yusup Iyus Maolana, Listyowati Indrarini,
Fauzia Retna Putri, Bratadiredja Marline Abdassah, Mutalib Abdul, Soetikno Ristaniah D. and
Soedjanaatmadja R. Ukun M.S.
255-259
46. Utilization of Sericin on Modification of Cotton Dyeing using Acid Dyes
- Ramadhani Puri Awaliyah and Umam Khairul
260-266
47. Toxicity of Seed oil of Azadirachta indica, Calophyllum inophyllum and their Mixture against
Crocidolomia pavonana Larvae
- Kadarusman Ratna Puji Astuti, Widayani Neneng S., Dono Danar, Hidayat Yusup, Sunarto Toto,
Hartati Sri and Maharani Rani
267-273
48. Addition of mango essence to methyl eugenol more attracted to Bactrocera dorsalis Complex
(Diptera: Tephritidae) on mango plantation in Majalengka, West Java
- Susanto Agus, Djaya Luciana and Sudrajat Rian Aprianti
274-279
49. Solubility Improvement of Antimalaria Drug through Co-Crystalization with Malic Acid
- Gozali Dolih, Alatas Fikri and Sugandi Rani
280-284
50.
Simple method and environmentally friendly ash content removal process from rice husk char using
potassium carbonate solution
- Solihudin, Rustaman and Haryono
285-288
51. Polymer Electrolyte Membrane Fuel Cell based on Sulfonated Polystyrene and Phosphoric Acid with
Biocellulose as a Matrix
- Fadlinatin Naumi, Christi L. Natanael, Iman Rahayu, Lucia Indrarti and Sunit Hendrana
289-293
52. A Voltammetric Immunosensor for Detection of HER2 using Gold Modified-Screen Printed Carbon
Electrode
- Hartati Yeni Wahyuni, Beladona Siti U. Misonia, Wyantuti Santhy and Gaffar Shabarni
294-301
53. Fast and Simultaneous Detection of Sm, Eu, Gd, Tb and Dy using combination of Voltammetry
Method and Multivariate Analysis
- Wyantuti Santhy, Pratomo Uji, Hartati Yeni Wahyuni, Anggraeni Anni and Bahti Husein H.
302-306
54. Vannamei Shrimp (Litopenaeus vannamei, Boone, 1931) Performance with Bacillus and Lactobacillus
Probiotic Formulation Consortium in Dry Preparation
- Andriani Yuli, Safitri Ratu and Fauziah Shaiyanne
307-312
vi
55. The Implementation of Natural Pigments of Pumpkin Meal to enhance the Color Quality of Koi Fish
(Cyprinus carpio)
- Yustiati Ayi, Arisya Yuni, Herawati Titin, Rachman Boedi and Andriani Yuli
313-318
56. Novel Mechanical Filter for reducing Ammonia Concentration of Silver Barb culture in a
Recirculating Aquaculture System (RAS)
- Hasan Zahidah, Rajibbusalam, Maulina Ine and Andriani Yuli
319-324
57. The Reduction of Lead in Fish Meat from Floating Net Cages in Cirata Reservoir by Citric Acid
- Junianto, Hasan Zahidah and Afrianto Eddy
325-329
58. Cytotoxic Sesquiterpenoid from the Stembark of Aglaia argentea (Meliaceae)
- Harneti Desi, Farabi Kindi, Nurlelasari, Maharani Rani, Supratman Unang and Shiono Yoshihito
330-333
59. Cellulose isolation from Gracilaria Genus and its Potential as Bioethanol Raw Material
- Satiyarti Rina Budi, Febrishaummy Indriani, Yun Yenny Febriyani and Mulyani Rahmaniar
334-336
60. Sn (IV) doped lanthanum silicate apatite structure (La9.33Si6-xSnxO26; x: 0.1; 0.3; 0.5) as an electrolyte
- Noviyanti Atiek Rostika, Eddy Diana Rakhmawaty, Hastiawan Iwan, Dzulfikar Muhammad
and Syarif Dani Gustaman
337-341
61. Determination of Individual Spectra of Sm, Eu, Gd, Tb and Dy from the UV-Vis Spectrum of
Mixture Solution
- Anggraeni Anni, Avian Mohamad Sepril, Purnama Andrew and Mutalib Abdul
342-346
62. Secondary Metabolites from Steambarks of Dysoxylum alliaceum
- Mayanti Tri, Nurcahyanti Ois, Darwati, Julaeha Euis, Farabi Kindi, Sumiarsa Dadan
and Dinata Deden Indra
347-350
Research Journal of Chemistry and Environment_______________________________Vol. 22(Special Issue II) August (2018) Res. J. Chem. Environ.
255
Comparison of Different Methods for Purification of Gold Nanoparticles– Polyamidoamine (PAMAM)
Generation 4 Dendrimer Narsa Angga Cipta1,2*, Pujiyanto Anung3, Gunawan Adang H.3, Yusup Iyus Maolana4, Listyowati Indrarini4,
Fauzia Retna Putri1, Bratadiredja Marline Abdassah5, Mutalib Abdul1, Soetikno Ristaniah D.4
and Soedjanaatmadja R. Ukun M.S.1
1. Department of Chemistry, Faculty of Mathematics and Science, Universitas Padjadjaran, Jatinangor, Sumedang, West Java, INDONESIA
2. Pharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Mulawarman University, Samarinda,
East Kalimantan, INDONESIA
3. Center of Radioisotopes and Radiopharmaceuticals, National Nuclear Energy Agency, Serpong, Tanggerang, INDONESIA
4. Department of Radiology, Faculty of Medicines, Universitas Padjadjaran, Bandung, West Java, INDONESIA 5Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, INDONESIA
*anggaciptan@yahoo.com
Abstract Gold nanoparticles (AuNP) are currently being widely
applied in cancer diagnosis as a CT Scan contrast
agent (imaging) as well asin therapy (theragnostic
agents). The polyamidoamine (PAMAM) G4
dendrimer has also been applied as a stabilizer agent
to control the size of gold nanoparticles. In the
production of AuNP-PAMAM G4 dendrimer, a solvent
and reducing agent were used. Therefore, it is
necessary to separate and purify the synthesis result of
AuNP-PAMAM G4 dendrimer from the undesired
compounds.
Separation and purification were carried out by two
different methods, namely, size exclusion column
chromatography Sephadex G25® (SE), and membrane
ultrafiltration (MU). The percent yield of AuNP that
has been synthesized was calculated by using
Inductively Couple Plasma Atomic Emission
Spectroscopy (ICP-OES) and then characterized by
using UV-Vis Spectroscopy and Transmission
Electron Microscope (TEM). The percent yield of
AuNP, which was carried out by MU, was 93.75%.
This result was better compared to using SE (81.18%).
The characteristics results from the UV-Vis spectrum
demonstrated similar spectra between separation and
purification methods using both MU and SE. The
characteristics results from TEM also showed similar
morphological results.
Keywords: Contrast agents, CT-Scan, dendrimer, gold
nanoparticles, purification.
Introduction The rapid development of nanotechnology has recently led
to research on the synthesis or manufacture of therapeutic
agents as well as the diagnosis (theragnostic) on the
nanoscale, one of which involves gold nanoparticles. The
gold nanoparticles were used as theragnostic agents,
attributable to their advantages over the conventional one
(iodine). Gold nanoparticles have higher atomic numbers
and electron densities and are not toxic in a large
concentration range, and their gold surface is easily modified
for targeted delivery1-3. The technology used in the
production of gold nanoparticles often involves top-down
and bottom-up methods. The bottom-up method involves a
stabilizer to prevent aggregation, and as a template for the
growth of nanoparticles4.
In the production of gold nanoparticles, tetrachloro auric
acid (HAuCl4) is reduced by sodium borohydride (NaBH4)
and PAMAM G4 dendrimer as a stabilizer agent for growing
the template and controlling the particle size of the gold
nanoparticles. Tetrachloroauric acid was produced by
dissolving Au foil using aqua regia/ HCl: HNO3 (3:1)6. The
excess of organic solvents and reducing agents must be
removed by using some method of separation and
purification such as size exclusion column chromatography
(SE) and membrane ultrafiltration (MU).
This work involves the comparison of two purification
methods of gold nanoparticles PAMAM G4 using SE and
MU. The optimal yield will be a consideration to determine
the most suitable method for this purification. Furthermore,
gold nanoparticles PAMAM G4 dendrimer can be used
safely as a cancer theragnostic agent and this approach can
be used as a prototype for the manufacture of a larger
production scale.
Material and Methods Materials: Au foil was purchased from PT. Antam
(Indonesia), and all chemicals were obtained from Aldrich
(USA) and Merck (Germany).
Preparation of HAuCl4 solution: Au foil was dissolved in
aqua regia (HCl: HNO3 = 3:1). The solution was stirred and
heated at 100°C (kept not to burst), and then dissolved with
demineralized water. The dissolution with demineralized
water and heating process was performed three independent
times. Finally, HAuCl4 was dissolved in 0.01 M HCl
solution.
Synthesis and characterization of AuNP-PAMAM G4
dendrimer: The prepared HAuCl4 solution (0.635 mL) was
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