View
51
Download
0
Category
Tags:
Preview:
DESCRIPTION
School of Computer Science. The effect of food on triggering type II diabetes: modeling a CBD Pancreas. Mohamed Raef Smaoui April 26 th , 2012. Outline. Role of pancreas Type II diabetes Modeling pancreas reaction (ODE) Modeling Beta Cells in pancreas (CBD) Simulation & Results. Outline. - PowerPoint PPT Presentation
Citation preview
The effect of food on triggering type II diabetes: modeling a CBD Pancreas
Mohamed Raef SmaouiApril 26th, 2012
School of Computer Science
1
Outline• Role of pancreas
• Type II diabetes
• Modeling pancreas reaction (ODE)
• Modeling Beta Cells in pancreas (CBD)
• Simulation & Results
2
Outline• Role of pancreas
• Type II diabetes
• Modeling pancreas reaction (ODE)
• Modeling Beta Cells in pancreas (CBD)
• Simulation & Results
3
What happens when you eat?
4
Role of pancreas
5
Role of pancreas
6
Outline• Role of pancreas
• Type II diabetes
• Modeling pancreas reaction (ODE)
• Modeling Beta Cells in pancreas (CBD)
• Simulation & Results
7
Type II diabetes
8
Type II diabetes (beta cells)
9
Type II diabetes (amyloids)
10
Glucose / Insulin in Diabetes
11
Pancreas
Beta-Cells
INSULIN
GLUCOSE
Outline• Role of pancreas
• Type II diabetes
• Modeling pancreas reaction (ODE)
• Modeling Beta Cells in pancreas (CBD)
• Simulation & Results
12
Pancreas reaction ODE
13
Victor Bolie, Coefficients of normal blood glucose regulation, J of Applied Physiology 61
Glucose / Insulin in Diabetes
14
INSULIN
GLUCOSE
Glucose / Insulin in Diabetes
15
INSULIN
GLUCOSE
Beta-Cells
Pancreas
Outline• Role of pancreas
• Type II diabetes
• Modeling pancreas reaction (ODE)
• Modeling Beta Cells in pancreas (CBD)
• Simulation & Results
16
Simulation (demo)
• buildSystem.py
17
1700 Cal /day (400 breakfast, 900 lunch, 400 dinner)
18
2500 Cal /day (200 breakfast, 1300 lunch, 1000 dinner)
19
4000 Cal /day (650 breakfast, 3000 lunch, 350 dinner)
20
Conclusion
• Modelled Glucose / Insulin (ODE)• 100 Beta cells cooperate to produce insulin• Each Beta Cell can– produce variable insulin and amylin (Dirichlet dist)– Infect neighbors upon death
• Diet recommendation by myHealth.py
21
References• Westermark et al., Islet amyloid polypeptide, islet amyloid, and diabetes
mellitus, Physiol Rev (2009).• Marzban et al., Islet amyloid polypeptide and type 2 diabetes,
Experimental Gerontology (2003).• Lara and Vangheluwe, Atom3: a tool for multi-formalism meta-modeling,
ETAPS (2002).• Smaoui, A computational framework to create an ensemble of stable
amyloid fibrils, McGill University (2011).• Victor Bolie, Coefficients of normal blood glucose regulation, J of Applied
Physiology (1961).
22
Recommended