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2008

Nanomaterial Self-Assembly

1 m

Cell-Biomaterial Interactions

100 m

Microfluidics & Microreactors

Nano-Micro-Bio ThemesNano-Micro-Bio Themes

2 m

Tool BoxTool Box

1 mAlcohol

Nanoparticles in Aqueous Droplet

Self-Assembled Microspheres

TimeDiffusion

(NH4)2SO4 (aq)

Oil

BaCl2 (aq)

BaSO4

Nanoparticles

Micromixing

Emulsion

Nucleation

NanoparticleProduction

Confined Self-Assembly

Layer-by-Layer Self-Assembly

Soft Lithography

2 m

Negatively Charged Particles

Positively Charged Polyelectrolytes

+ + + ++ + + +- - - - -- - - - -+ + + ++ + + +- - - - -- - - - -+ + + ++ + + +

-- -- -- -- -- ---- -- -- -- -- -- --

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-- -- -- -- -- -- --+ + + ++ + + +

-- -- -- -- -- ---- -- -- -- -- -- --

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-- -- -- -- -- -- --+ + + ++ + + +

-- -- -- -- -- ---- -- -- -- -- -- --

-- -- -- -- -- -- ---- -- -- -- -- ----

-- -- -- -- -- -- --

--

+ + + ++ + + +

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Microfluidic Device Fabrication and Imaging

S. epidermidisCells

Osteoblast Cells

ProjectsProjects

• Application: On-demand chemical synthesis using micro-structured reactors

• Goal: Develop a catalyst coating process to infiltrate and immobilize commercially available catalyst particles

• Team: Dr. H. Qiu, Prof. A. Lawal• Funding: DOE, NJCST

Catalyst Infiltration & Immobilization

Substrate

Yb2O3

SiO2

ParticleAssembly

Viscous/ReactiveSintering

Yb2SiO5

Substrate

• Application: Next-generation gas turbine components above 1300˚C

• Goal: Develop a new Yb2SiO5 coating process for complex shape components

• Team: Dr. Y.-F. Su• Funding: ONR

High-Temperature Ceramic Coating

~10 mRDX+PolymerMicrosphere

~100 nmRDX

Nanocrystals

PolymerCoating

Bullet Hole

“Insensitive 155 Projectile”

• Application: RDX nanocrystals for insensitive munitions

• Goal: Develop a manufacturing process for producing and coating RDX nanocrystals with reduced safety and health concerns

• Team: Dr. Greenberg, Dr. R. Halder, Dr. H. Qiu, Prof. Koven, Prof. Libera from Stevens and V. Stepanov, Dr. P. Anderson, and A. DiStasio from U.S. Army

• Funding: ARDEC

Nano-Energetic Materials

Physiological Framework of Microenvironment

ECM Protein

S. epidermidis

Therapeutic

Host DefenseOsteoblast

Biomaterial

Device Functions• Microfluidic Multiplexing• Nontransparent Biomaterial• Time-lapsed Imaging

• Application: Predictable in vitro infection model for biomedical devices

• Goal: Image cell interactions with clinically relevant biomaterial under controlled microenvironment

• Team: J.H. Lee, A. Ihnen, T. Boyd (Technogenesis Scholar), Prof. Wang, Prof. Libera

• Funding: NSF-NIRT Subgroup

Bacteria-Eukaryotic Cell-Biomaterial Interactions

10 m

10 nm

New Jersey Center for MicroChemical SystemsNew Jersey Center for

MicroChemical Systems

2008 ChE Senior Design:Fast-Acting Ibuprofen

D. Kandl, M. Abdul-Adziz, M. Muchnik, I. Handel

Flow

Nanostructured Surfaces

Engineered Microenvironment

New NanoscaleMaterials and Phenomena

MicrostructuredDevices

Systems (“Good”)Engineering

Chemical and BiologicalSystems of Future

DARPA

$12M Stevens-led teams since 2002 with partners & sponsors