Causes of Mesothelioma

Causesof

mesothelioma

Asbestos

Asbestos is the commercial name for a group of hydrated silicate fibrous materials.

1

Chrysotile Amosite

Crocidolite

Tremolite

Serpentine Amphibole

Anthophyllite

Actinolite

Asbestos is the commercial name for a group of hydrated silicate fibrous materials.

1

there aretwo types

of asbestos

2

11 million

exposed people between 1940-783

11 million

exposed people between 1940-783

expected latency period after exposure

25-50 years

11 million

exposed people between 1940-783

expected latency period after exposure

25-50 years

sharp increase in mesothelioma cases in the US

1970s – 1990s

leveled off in1992

11 million

exposed people between 1940-783

expected latency period after exposure

25-50 years

sharp increase in mesothelioma cases in the US

1970s – 1990s

asbestos regulations were passed1980s

11 million

exposed people between 1940-783

expected latency period after exposure

25-50 years

sharp increase in mesothelioma cases in the US

1970s – 1990s

asbestos regulations were passed1980s

trace amounts of asbestos may still be allowed legally

11 million

exposed people between 1940-783

expected latency period after exposure

25-50 years

sharp increase in mesothelioma cases in the US

1970s – 1990s

asbestos regulations were passed1980s

trace amounts of asbestos may still be allowed legally

some developing countries still continue to use asbestos

11 million

exposed people between 1940-783

expected latency period after exposure

25-50 years

sharp increase in mesothelioma cases in the US

1970s – 1990s

asbestos regulations were passed1980s

trace amounts of asbestos may still be allowed legally

some developing countries still continue to use asbestos

All of this add up to the persistence of mesothelioma in the coming years

Country Production (metric

tons)

Russia 1,000,000

China 400,000

Brazil 270,000

Kazakhstan 214,000

Canada 100,000

Major Producers of Asbestos5

Asbestos cement sheets

Fire rated doors

Asbestos cement pipes

Low density insulating boards

Brake pads

replacedsince 1995

Vinyl floor tiles

Fireproofing

Acoustic ceilings

Gaskets

Drilling fluid additives

also in: Mining Ship building Paper milling Railroad repair Ceramics

also in: Mining Ship building Paper milling Railroad repair Ceramics

Sourcesof

Asbestos

Sourcesof

Asbestos

Carbon Nanotubes

Carbon nanotubes are allotropes of carbon with awide array of applications in electronics, optics

4

AnimalModels

only

similar dimensions and chemical property as asbestos

Carbon nanotubes are allotropes of carbon with awide array of applications in electronics, optics

4

AnimalModels

onlySingle-walled

Multi-walled

Nanotorus

Nanobud

Grafinated

Nitrogen doped

Peapod

Extreme

Cup-stacked

There aredifferent

types

What are the current applications of carbon nanotubes?

Wind turbines

Marine paints

Ice hockey sticks

Surf boards

Baseball bats

Maritime vessels

Handlebars

Seat posts

Scaffolding for bone growth

Golf clubs

Simian Virus 40

SV-40 is the 50s & 60s polio vaccine contaminant

MixedReviews

SV-40 is the 50s & 60s polio vaccine contaminant

MixedReviews

10-30 million people exposed to SV-40 contaminated polio vaccines

1955-63

BAP1 gene defects

Official Name: BRCA1 Associated Protein-1Regulate key histones and transcription factors related to tumor development

BAP1 gene is located on chromosome 3

OtherPotentialCauses

Radiation therapy

Radiation to supradiaphragmatic fields

OtherPotentialCauses

Radiation therapy

Radiation to supradiaphragmatic fields

Intrapleural thorium dioxide

OtherPotentialCauses

Radiation therapy

Radiation to supradiaphragmatic fields

Intrapleural thorium dioxide

Zeolites

OtherPotentialCauses

An example is erionite which is common in Turkey

References

1. Daniel H Sterman, MD, et al. Epidemiology of malignant mesothelioma. UpToDate version 19.3

1. Daniel H Sterman, MD, et al. Epidemiology of malignant mesothelioma. UpToDate version 19.3

2. Wikipedia, the free encyclopedia. Mesothelioma 2. Wikipedia, the free encyclopedia. Mesothelioma

3. National Institute of Health3. National Institute of Health

4. Wikipedia, the free encyclopedia. Carbon nanotubes4. Wikipedia, the free encyclopedia. Carbon nanotubes

5. U.S. Geological Survey, Mineral Commodity Summariesupdated March, 2013

5. U.S. Geological Survey, Mineral Commodity Summariesupdated March, 2013

What Next?What Next?

What are the symptoms of mesothelioma?What are the symptoms of mesothelioma?

How is mesothelioma diagnosed?How is mesothelioma diagnosed?

What is the survival rate of mesothelioma?What is the survival rate of mesothelioma?

How is mesothelioma treated?How is mesothelioma treated?

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