Ectrims focused workshop environmental, modifiable risk factors for MS 2016 final programme

3 – 4 March 2016, Florence, Italy

ectrIMSFocUSeD WorKShoP

WELCOME TO FLORENCE

Dear friends and colleagues,

Welcome to Florence for the occasion of the 4th ECTRIMS Focused Workshop on “Environmental, modifiable risk factors for multiple sclerosis”. This year’s workshop follows the previous focused workshops on “MS and Gender”, “New technologies in MS care”, “Immunology of multiple sclerosis—from a human point of view” in 2013, 2014 and 2015.

Why arrange a meeting specifically addressing environmental modifiable risk factors for MS?

As other complex disorders, MS is most probably caused by interaction of genetic factors--largely elucidated--and environmental factors that are now better investigated and recognized, thanks to a great deal of research performed in this field over the past two decades.

In recent years, formidable biochemical, bio-informatic, technological and epidemiological tools have been involved to move on research into the causes of MS. In our view, the MS landscape has been irreversibly transformed by this progress.

Are we now in a time when we can speak of reducing the risk of MS by removing some risk factors, modifying subject lifestyle, working at potential preventive strategies? Are we able to mitigate the severity of the disease course-- not only with appropriate therapies-- by also modifying some of these factors? A few identified factors, in fact, may act not only as risk factors that increase the susceptibility to the disease, but, at the same time, as factors that influence the disease course and prognosis.

During the workshop, we will review current scientific knowledge in the area, coming from epidemiological studies, clinical trials and basic research. Moreover, we will address potential biological mechanisms underlying the association between MS and these factors. Then, we will discuss whether –at the present stage—from the body of available knowledge, there are any implications for improving patient counselling and management.

Lastly, and most importantly, “where are we headed”? The workshop will help identify the most important perceived gaps in knowledge and avenues for future research in this field. Improving our understanding of the environmental factors involved in MS risk and prognosis can in fact lead to new and more-effective approaches to prevention and management of this disease.

We hope that you will enjoy a fruitful and enlightening meeting that will result in the exchange and discussion of the most recent knowledge about the etio-pathogenesis of multiple sclerosis.

Florence has been selected as the venue for this year’s meeting, and we hope that you will enjoy the beauty of the location with its fascinating history and artistic treasures.

Yours sincerely,

Maria Pia Amato Xavier Montalban David Miller Workshop Organiser ECTRIMS President ECTRIMS Vice-President

FOCUSED WORKSHOP PROGRAMME

THURSDAY, 3 MARCH 2016

09.00 – 09.15 Welcome and Introduction San Michele X. Montalban (Barcelona, ES), M.P. Amato (Florence, IT) 09.15 – 10.30 Session 1: Gene-environment interactions San Michele Chair: X. Montalban (Barcelona, ES), M.P. Amato (Florence, IT)

09.15 Insights about the concept of risk M.P. Amato (Florence, IT)

09.30 Gene-environment interactions in inflammatory disease other than MS: the model of celiac disease L. Sollid (Oslo, NO)

10.00 Gene-environment interactions in MS T. Olsson (Stockholm, SE)

10.30 – 11.00 Coffee Break Tower Bar / I Salotti

11.00 – 13.00 Session 2: Infections and vaccines San Michele Chairs: P. Soelberg Sørensen (Copenhagen, DK) 11.00 The hygienic hypothesis in MS J. Correale (Buenos Aires, AR) 11.30 Infectious agents as risk factors I. Steiner (Petach Tikva, IL)

12.00 Epstein Barr Virus: epidemiological evidence J. Lünemann (Zurich, CH)

12.30 Epstein Barr Virus: experimental and pathological evidence, potential mechanisms of action

C. Münz (Zurich, CH)

13.00 – 14.30 Lunch Break Stemma (First Floor) 14.30 – 15.30 Session 2: Infections and vaccines (continued) San Michele Chairs: G. Giovannoni (London, UK), M. Salvetti (Rome, IT)

14.30 Vaccines and the risk of MS/MS relapses: a review of the evidence (or lack of)

S. Vukusic (Lyon, FR)

15.00 Discussion: “Infectious agents and vaccines. What are the implications for prevention and treatment?”

Facilitator: G. Giovannoni (London, UK)

15.30 – 16.00 Coffee Break Tower Bar / I Salotti 16.00 – 18.00 Session 3: Vitamin D San Michele Chairs: A. Ascherio (Boston, US), M. Trojano (Bari, IT)

16.00 Vitamin D: Epidemiological evidence R.M. Lucas (Canberra, AU)

16.30 Vitamin D: Experimental evidence and potential mechanisms of action J. Smolders (Maastricht, NL)

17.00 Results of therapeutic trials A. Ascherio (Boston, US)

17.30 Discussion: Vitamin D. What are the implications for prevention and treatment? What is the most appropriate dose?

Facilitator: E. Waubant (San Francisco, US)

18.00 – 18.15 Wrap Up San Michele 19.15 Focused Workshop Dinner (Meeting point at hotel lobby, Dinner starts at 19.30h)

FRIDAY, 4 MARCH 2016

09.00 – 10.30 Session 4: Other risk factors: epidemiological and San Michele Experimental evidence, potential mechanisms of action Chairs: R. Liblau (Toulouse, FR), T. Riise (Bergen, NO)

09.00 Cigarette smoking P. Sundström (Umea, SE)

09.30 Body Mass Index

M. Pugliatti (Ferrara, IT)

10.00 High dietary salt

R. Linker (Erlangen, DE)

10.30 – 11.00 Coffee break Tower Bar / I Salotti

11.00 – 13.00 Session 4: Other risk factors: epidemiological and San Michele experimental evidence, potential mechanisms of action (continued) Chairs: D. Miller (London, UK), T. Derfuss (Basel, CH)

11.00 Alcohol and caffeine intakes L. Alfredsson (Stockholm, SE); T. Olsson (Stockholm, SE)

11.30 Stress A. Miller (Haifa, IS)

12.00 Modifiable comorbidities; a missed opportunity? H. Tremlett (Vancouver, CA)

12.30 A common pathway for environmental risk factors in MS? The microbiome – gut-brain axis H. Wekerle (Munich, DE)

13.00 – 14.00 Lunch break Stemma (First Floor)

14.00 – 14.30 Session 4: Other risk factors: epidemiological and San Michele experimental evidence, potential mechanisms of action (continued) Chairs: D. Miller (London, UK), T. Derfuss (Basel, CH)

14.00 Discussion: Other risk factors: what are the implications for prevention and treatment?

Facilitator: R. Liblau (Toulouse, FR) 14.30 – 14.45 Wrap-up, state-of-the art and future directions San Michele M.P. Amato (Florence, IT)

ACCOMODATION AND LECTURE ROOM

Hotel Brunelleschi

Piazza Santa Elisabetta, 3

50122 Florence / Italy

Phone +39 05527370

INFORMATION FOR SPEAKERS

The lecture room “San Michele” is equipped with a lectern at which you can hold your presentation. A projector and screen are at your disposal to display your Power Point presentation.

Please bring your presentation on an USB stick or external hard drive and upload it on the presentation laptop in the lecture room before your presentations. A technician will be in the room during the whole time to assist you with any problems that may arise.

FOCUSED WORKSHOP DINNER

The Focused Workshop Dinner on Thursday, 3 March 2016 will take place at the

Restaurant Il Locale.

Please find the details of the evening below

Date: Thursday, 3 March 2016

Meeting Time: 19.15 hrs

Meeting Point: Hotel Lobby

FOCUSED WORKSHOP PARTICIPANTS

First Name Name City Country Email

Alfredsson Lars Stockholm SE Lars.Alfredsson@ki.se

Aloisi Luca Rome IT francesca.aloisi@iss.it

Amato Maria Pia Florence IT mariapia.amato@unifi.it

Ascherio Alberto Boston US aascheri@hsph.harvard.edu

Bjørnevik Kjetil Bergen NO Kjetil.Bjornevik@uib.no

Comabella Manuel Barcelona ES manuel.comabella@vhir.org

Correale Jorge Buenos Aires AR jcorreale@fleni.org.ar

Cortese Marianna Bergen NO Marianna.Cortese@uib.no

D'Alessandro Roberto Bologna IT roberto.dalessandro@ausl.bologna.it

Derfuss Tobias Basel CH tobias.derfuss@usb.ch

D'Hooghe Marie Brussels BE marie.dhooghe@mscenter.be

Ghezzi Angelo Milan IT angelo.ghezzi@aogallarate.it

Giovannoni Gavin London UK g.giovannoni@qmul.ac.uk

Hellwig Kerstin Bochum DE k.hellwig@klinikum-bochum.de

Hemmer Bernhard Munich DE hemmer@lrz.tum.de

Koch-Henriksen Nils Copenhagen DK koch-henriksen@stofanet.dk

Langer Gould Annette Pasadena US annette.m.langer-gould@kp.org

Liblau Roland Toulouse FR roland.liblau@inserm.fr

Linker Ralf Erlangen DE Ralf.Linker@uk-erlangen.de

Lolli Francesco Florence IT francesco.lolli@unifi.it

Lucas Robyn Canberra AUS robyn.lucas@anu.edu.au

Lünemann Jan Dirk Zurich CH jan.luenemann@uzh.ch

Magyari Melinda Copenhagen DK melinda_magyari@dadlnet.dk

Massacesi Luca Florence IT luca.massacesi@unifi.it

Miller David London UK david.h.miller@ucl.ac.uk

Miller Ariel Haifa IS milleras@netvision.net.il

Montalban Xavier Barcelona ES xavier.montalban@cem-cat.org

Monteyne Philippe Rixensart BE philippe.monteyne@gmail.com

Morley Pamela London UK member@pmorley.fsnet.co.uk

Mowry Ellen Baltimore US emowry1@jhmi.edu

Münz Christian Zurich CH christian.muenz@uzh.ch

Nielsen Nette Copenhagen DK nmn@ssi.dk

Olsson Tomas Stockholm SE Tomas.Olsson@ki.se

Oreja-Guevara Celia Madrid ES orejacbn@gmail.com

Otero Susana Barcelona ES sotero@cem-cat.org

Pugliatti Maura Ferrara IT mpugliatti@yahoo.com

Reingold Stephen Salibury US scra.llc@earthlink.net

Riise Trond Bergen NO trond.riise@igs.uib.no

Robertson Neil Cardiff UK robertsonnp@cardiff.ac.uk

Salvetti Marco Rome IT marco.salvetti@uniroma1.it

Sidhom Youssef Paris FR youssef.sidhom@gmail.com

Siracusa Gianfrano Florence IT siracusag@ao-careggi.toscana.it

Smolders Joost Maastricht NL smolders@gmail.com

FOCUSED WORKSHOP PARTICIPANTS

First Name Name City Country Email

Soelberg Sørensen Per Copenhagen DK per.soelberg.soerensen@rh.regionh.dk

Sollid Ludvig Oslo NO l.m.sollid@medisin.uio.no

Steiner Israel Petach Tikva IL israels@ekmd.huji.ac.il

Stenager Egon Aarhus DK egon.stenager@shs.regionsyddanmark.dk

Sundström Peter Umeå SE peter.sundstrom@umu.se

Taylor Bruce Hobart AUS bruce.taylor@utas.edu.au

Tremlett Helen Vancouver CA helen.tremlett@ubc.ca

Trojano Maria Bari IT maria.troiano@uniba.it

Uccelli Antonio Genova IT auccelli@neurologia.unige.it

Vukusic Sandra Lyon FR sandra.vukusic@chu-lyon.fr

Waubant Emmanuelle San Francisco US Emmanuelle.Waubant@ucsf.edu

Wekerle Hartmut Munich DE hwekerle@neuro.mpg.de

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