Dr Patrick Dixon Chairman Global Change LtdFellow, Centre for Management Development, London Business School

FutureofHealthandthetruthaboutlifeexpectancy

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RANDOMCUTANDPASTE

The future is aboutEMOTION

85% of world population will be living in emerging

markets in 10 years

1% owns 50% of wealth

Europe Dying 4 couples to produce single great-grand child

1 million in Italy over 90 years old by 2026

Title Text• Body Level One

– Body Level Two

• Body Level Three

– Body Level Four

» Body Level Five

!18

• 125,000 stents or carotid surgery a year in US

Read your genes in 2 hours for

£1200

•Pigsteethgrowninsiderats•Micegrownewteethfromnervecells/gum>ssue

Grow New Teeth

Repair Heart / Brain / Retina / Spine

Rod photoreceptors (in green) within a "mini retina" derived from human induced Pluripotent Stem Cells in the lab. Courtesy of Johns Hopkins Medicine

An6-Ageingwillbeaglobal

obsession-withrapidprogress

Want to look better - $200bn pa by 2020

may be

Want to think better......

•20%studentsinUS/UKusememorydrugstopassexams

7mechanismsofageinginanimalandhumancells

•Celllossoratrophywithoutreplacement•Nuclearmuta>onsandepimuta>onsthatcausecancer•Mitochondrialmuta>ons•Cellsenescence(deathresistance)•Junkinsidecells•Junkoutsidecells•Cross-linksbetweencells(egelas>n)

Worn out Mitochondria – Energy Boost

R-alpha-lipoic acidAcetyl-L-carnitine

Treatment which restores and maintains the youthful elasticity of

hardened arteries – and helps wrinkled skin. Global sales?

Low blood pressure and total body lift

Alteon

Monkeysondietlivelonger•AGer20years-80%alivev50%onnormalcalories• Lesscancer,diabetes,heartdisease,strokes,braindecay

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Slow or no ageing is a reality

• Rockfish, Turtles, some Whales

• No signs of getting old

Rougheye rockfish (Sebastes aleutianus) — 205 years Aldabra Giant Tortoise — 255 years Lobsters are believed to live 100 or more years Ocean Quahog clam — 405 years

Some animals do not “age” in normal way

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40 years old today - 82 projection

Every year adds 3% to pension deficit

40 years old today - 82 projection82 + 5 (middle class)

Every year adds 3% to pension deficit

40 years old today - 82 projection82 + 5 (middle class) 87 + 10 (1 year in 4: 40 years)

Every year adds 3% to pension deficit

40 years old today - 82 projection82 + 5 (middle class) 87 + 10 (1 year in 4: 40 years)97 + 5 (therapies in 30 years)

Every year adds 3% to pension deficit

40 years old today - 82 projection82 + 5 (middle class) 87 + 10 (1 year in 4: 40 years)97 + 5 (therapies in 30 years)102 + 5 (therapies in next 30 years)

Every year adds 3% to pension deficit

40 years old today - 82 projection82 + 5 (middle class) 87 + 10 (1 year in 4: 40 years)97 + 5 (therapies in 30 years)102 + 5 (therapies in next 30 years)107 new average life expectancy

Every year adds 3% to pension deficit

Dr Patrick Dixon Chairman Global Change Ltd

Increasedlifeexpectancywillimpacteveryna>onandevery

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