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The New England Journal of Medicine Downloaded from nejm.org at NIH on December 22, 2013. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

Replacement Therapy for Inherited Enzyme Deficiency

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The New England Journal of Medicine Downloaded from nejm.org at NIH on December 22, 2013. For personal use only. No other uses without permission.

Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at NIH on December 22, 2013. For personal use only. No other uses without permission.

Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at NIH on December 22, 2013. For personal use only. No other uses without permission.

Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at NIH on December 22, 2013. For personal use only. No other uses without permission.

Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at NIH on December 22, 2013. For personal use only. No other uses without permission.

Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at NIH on December 22, 2013. For personal use only. No other uses without permission.

Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at NIH on December 22, 2013. For personal use only. No other uses without permission.

Copyright © 1991 Massachusetts Medical Society. All rights reserved.