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www.labthroughput.com845-425-9711845-270-8449
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©
LLTTP P is a software company dedicated to improving workflow efficiency and productivity in the clinical laboratory
LLTTP P Products: Automate results verification, review, follow-up actions
and disposition for Hematology, Coagulation, Chemistry & Immunochemistry, and Urinalysis
Optimize by monitoring workflow in real-time and retrospectively
Provide real-time Quality Control compliance Allow you to expand your hematology services to
automate BALBAL and other fluid analyses
2
©
What LLTTPP does
How LLTTPP worksHow the LLTTPP review-criteria optimization
process works
How LLTTPP reduces operating costs/improves profitability
What LLTTPP products are available products are available3
©
LLTTPP ACHIEVERACHIEVER™™
LLTTPP OPTIMIZEROPTIMIZER™™
LLTTPP BALBAL/HEMATOLOGY/HEMATOLOGY™™
4
LLTTPP QC SENTINELQC SENTINEL™™
LabLabThroughThroughPutPut ™™
GlobaLab Efficiency Products
LLTTPP MIDDLEWAREMIDDLEWARE™ ™ SYSTEM SYSTEM ConfigurationConfiguration
©
LLTTPP ACHIEVERACHIEVER™™
LLTTPP OPTIMIZEROPTIMIZER™™
LLTTPP BALBAL/HEMATOLOGY/HEMATOLOGY™™
LLTTPP GlobaLabGlobaLab ™ ™ Products Products
5
LLTTPP HEMATOLOGYHEMATOLOGY™™
LLTTPP COAGULATIONCOAGULATION™™ LLTTPP CHEMISTRYCHEMISTRY™™ LLTTPP URINALYSISURINALYSIS™™
LLTTPP HEMATOLOGYHEMATOLOGY™™
LLTTPP COAGULATIONCOAGULATION™™ LLTTPP CHEMISTRYCHEMISTRY™™ LLTTPP URINALYSISURINALYSIS™™
LLTTPP QC SENTINELQC SENTINEL™™
©
LLTTPP ACHIEVERACHIEVER is a system that optimizes results processing in the laboratory and improves productivity
ACHIEVER MODULESACHIEVER MODULES
◼ SYSTEM SETUP and SECURITY
◼ INSTRUMENT MANAGER
◼ EVALUATOR
◼ PROCESSOR
◼ ENDSHIFT
◼ MONITOR
6
LLTTPP ACHIEVERACHIEVER™™
©
LLTTPP ACHIEVERACHIEVER is a system that optimizes results processing in the laboratory and improves productivity
ACHIEVER MODULE ACHIEVER MODULE Functionality◼ SYSTEM SETUP and SECURITY
Provides for Defining: access level heirarchy, user/password control, parameters, review rules, edit/display order, and Shift report content and distribution
◼ INSTRUMENT MANAGERControls data transmission: receives data from analyzers and
LIS, transmits to analyzers and LIS; monitors connectivity
◼ EVALUATOR Evaluates results by autoverification of User Rules: assigns
samples to worklists and locates them for tech data entry screens, provides disposition of results
7
LLTTPP ACHIEVERACHIEVER™™
©
LLTTPP ACHIEVERACHIEVER is a system that optimizes results processing in the laboratory and improves productivity
ACHIEVER MODULE ACHIEVER MODULE Functionality PROCESSOR
Provides for all operations: label printing, data entry/modification, Supervisory review/approval, tracks current status and audit trail of results, and provides for archive and retrieval
ENDSHIFTCloses Instrument Manager at defined end of shift times;
creates, distributes and saves End of Shift Reports
MONITORChecks Instrument Manager and Evaluator continually, in the
background, for proper functioning of data entry/modification
8
LLTTPP ACHIEVERACHIEVER™™
©
WHAT LLTTPP ACHIEVERACHIEVER DOES LLTTPP ACHIEVERACHIEVER is a complete results
processing system.◼ Auto-verifies analyzer results◼ Issues follow-up worklists along with procedures ◼ Provides data entry screens for necessary results
changesOn-screen diffpad for microscopic observation entry
◼ Determines final disposition◼ Transmits results to the host computer system for
release◼ Stores every state of every specimen record in a
database; maintains audit trail◼ Self-monitors and diagnoses system operations◼ Produces activity and productivity reports
9
LLTTPP ACHIEVERACHIEVER™™
©
Functions User-definable setup of:
Review Rules Instrument and Lab-defined parameters to receive Parameters to be displayed/edited by techs, including
display order Parameters to be transmitted to LIS User names/passwords Access levels to system functions Shift Report contents and E-mail recipients
Features User defines which parameter value fields can be
edited by tech, and under which circumstances Parameter field background colors are user-
definable for clarity10
SYSTEM SETUP & SECURITY MODULESYSTEM SETUP & SECURITY MODULE
LLTTPP ACHIEVERACHIEVER™™
©
LLTTPP SYSTEM SETUP SCREENSSYSTEM SETUP SCREENS
©
LLTTPP SYSTEM SETUP REVIEW CRITERIA REPORTSYSTEM SETUP REVIEW CRITERIA REPORT
©
Functions Receives data from analyzers and LIS Transmits data to analyzers and LIS
Features Analyzer/Instrument Manager connectivity
diagnostics Host/Instrument Manager connectivity
diagnostics Issue connectivity alerts audibly, via E-mail and via text
messaging
13
INSTRUMENT MANAGER MODULEINSTRUMENT MANAGER MODULE
LLTTPP ACHIEVERACHIEVER™™
©
LLTTPP INSTRUMENT MANAGER SCREENINSTRUMENT MANAGER SCREEN
©
EVALUATOR Features: Follow-up procedure worklists are created based
on User criteria Special follow-up options include automatic
replacement of instrument parameter values by values obtained on the instrument by other means; e.g. WIC/WOC or analyte dilution results
Audit trail maintenance: Database archival of up to 1,000,000 specimen records Every state of every record is stored in a database All changes made to results are recorded/audit trailed
– WHO, WHEN and WHY any change was made– WHAT Method used to make the change
Final disposition state for each specimen record is recorded
15
LLTTPP ACHIEVERACHIEVER™™
EVALUATOR MODULEEVALUATOR MODULE
©
LLTTPP EVALUATOR MODULE SCREENEVALUATOR MODULE SCREEN
©
PROCESSOR Features: Open architecture supports simultaneous
analysis of any combination of:Multiple SpeciesAnalyzer manufacturers/models Body fluid types
Analyzes specimen results on-line in real-time, using your verification criteria. Special verification options include:
– Activation/de-activation of individual rules within a set– Advanced delta-check techniques – Color coding for: Rerun, Diff needed, Spun Hct– Tech ID, data entry, results and workstation tracked
17
LLTTPP ACHIEVERACHIEVER™™
PROCESSOR MODULEPROCESSOR MODULE
©
18
ENDSHIFT MODULEENDSHIFT MODULE
Endshift Features The Endshift process is entirely automatic
Stops Instrument Manager and Evaluator automatically
Restarts Instrument Manager and Evaluator automatically when Endshift process is completed
Endshift Report contents and recipients are User definable
Endshift will not occur if LLTTPP detects that specimens are still being processed
Endshift times can vary by day and shift Multiple Endshifts per day can be programmed Number of Endshift retries and retry intervals are
user definable
LLTTPP ACHIEVERACHIEVER™™
©
MONITOR Features: Monitors Evaluator and Instrument Manager for
functional compliance Starts automatically at beginning of shift and runs
in the background Restarts application(s) if fault is detected Maintains an all inclusive event Log
19
LLTTPP ACHIEVERACHIEVER™™
MONITOR MODULEMONITOR MODULE
©
LLTTPP MONITOR MODULE SCREEN MONITOR MODULE SCREEN
©
WHAT LLTTPP OPTIMIZER OPTIMIZER DOES LLTTPP OPTIMIZER OPTIMIZER ™ helps you optimize
specimen results throughput in the laboratory Uses your results-verification criteria to measure
the overall specimen-result review rate in the laboratory
Determines the frequency of follow-ups based on each criterion, and the frequency of each follow-up procedure; eg. analyzer reruns or manual differentials
Allows readjustment of criteria and re-analyzes the results to optimize criteria and improve throughput
Provides database query capability
21
LLTTPP OPTIMIZEROPTIMIZER™™
©
WHAT LLTTP P OPTIMIZER OPTIMIZER DOESOPTIMIZER Features
LLTTP P OPTIMIZEROPTIMIZER™ provides review rates: For all specimens combined Based on individual review criterion Based on instrument, for multiple-instrument
systems Based on instrument model, for labs using more
than one analyzer model (open architecture) Based on body fluid type, for labs running whole
blood samples and other body fluids Based on species, for veterinary labs
22
LLTTPP OPTIMIZEROPTIMIZER™™
©
Functions Queries either the live or archival database for
performance parameters Productivity summary by analyzer or by operator # of specimens analyzed over time interval per species,
analyzer, tech, body fluid type, etc. # of specimens work-listed per rule, per species, per
analyzer, per body fluid type # of follow-up actions per rule, per species, per analyzer, per
body fluid type
Features Analysis of archived results based on rules applied
live Analysis of archived results using modified review
rules23
LLTTPP OPTIMIZER OPTIMIZER QUERY MODULEQUERY MODULE
LLTTPP OPTIMIZEROPTIMIZER™™
©
WHAT LLTTPP ACHIEVERACHIEVER/HEMATOLOGY/HEMATOLOGY™ ™ DOES LLTTPP ACHIEVERACHIEVER/HEMATOLOGY /HEMATOLOGY is a complete
results processing system. Auto-verifies hematology analyzer results Issues follow-up worklists along with procedures Provides data entry screens for necessary results
changesOn-screen diffpad
Determines final disposition Transmits results to the host computer system for
release Stores every state of every specimen record in a
database
24
LLTTPP ACHIEVERACHIEVER/HEMATOLOGY/HEMATOLOGY™™
©
HOW the LLTTPP review-criteria optimization process works
SETUP REVIEW CRITERIA & SECURITY ENTER (AND EDIT) REVIEW CRITERIA
REVIEW-CRITERIA BATCH SCREEN REVIEW-CRITERION EDITOR
Review specimen record data Examine results of specimen record
review Edit review criteria and re-analyze data
25
LLTTPP HEMATOLOGYHEMATOLOGY™™
©
Functions User-definable setup of:
Review Rules Instrument and Lab-defined parameters to receive Parameters to be displayed/edited by techs, including
display order Parameters to be transmitted to LIS User names/passwords Access levels to system functions Shift Report contents and E-mail recipients
Features User defines which parameter value fields can be
edited by tech, and under which circumstances Parameter field background colors are user-
definable for clarity26
SYSTEM SETUP & SECURITY MODULESYSTEM SETUP & SECURITY MODULE
LLTTPP HEMATOLOGYHEMATOLOGY™™
©
LLTTPP HEMATOLOGY HEMATOLOGY SYSTEM SETUP SCREENSSYSTEM SETUP SCREENS
©
LLTTPP HEMATOLOGY HEMATOLOGY SYSTEM SETUP REVIEW CRITERIA REPORTSYSTEM SETUP REVIEW CRITERIA REPORT
©
LLTTPP HEMATOLOGY HEMATOLOGY REVIEW CRITERION SETUP SCREENREVIEW CRITERION SETUP SCREEN
©
Review criteria are grouped. A set (“batch”) of criteria is entered for each combination of instrument type/body fluid type/species (see slide 12)
Multiple sets can be active simultaneously, but only one set at a time can be active for each combination of instrument type/body fluid type/species
Sets and individual criteria can be de-activated
Specimens not matching any set are flagged Sets can be printed
30
ENTER/EDIT REVIEW CRITERIAENTER/EDIT REVIEW CRITERIA
LLTTPP HEMATOLOGYHEMATOLOGY™™
©
Review criteria include Limits
Parameter values Products of 2 parameter values Ratios of 2 parameter values Sums of 2 parameter values Differences of 2 parameter values % differences of 2 parameter values
Morphology Flags Presence Severity
System Operational Alerts Presence Severity
(CONTINUED ON NEXT SLIDE)
31
ENTER/EDIT REVIEW CRITERIAENTER/EDIT REVIEW CRITERIA
LLTTPP HEMATOLOGYHEMATOLOGY™™
©
Review criteria include: Demographics
Age Gender
Blanked resultsDelta Checks (Apply to any combination of parameters listed
above under limits) Difference Absolute difference % difference Absolute % difference Rate of delta for any of the above, by:
– Day, Week or Month
32
ENTER/EDIT REVIEW CRITERIAENTER/EDIT REVIEW CRITERIA
LLTTPP HEMATOLOGYHEMATOLOGY™™
©
INSTRUMENT TYPE
SPECIES
SPECIMEN TYPE
33
LLTTPP HEMATOLOGY HEMATOLOGY REVIEW CRITERIA BATCH SCREENREVIEW CRITERIA BATCH SCREEN
©
FORMULAS
34
LLTTPP HEMATOLOGY REVIEW CRITERION EDITOR SCREENHEMATOLOGY REVIEW CRITERION EDITOR SCREEN
CRITERIONACTION
PARAMETER THAT IS RE-ANALYZED AFFECTED PARAMETER(S)
©
PARAMETER LIST
35
LLTTPP HEMATOLOGY HEMATOLOGY REVIEW CRITERION EDITOR SCREENREVIEW CRITERION EDITOR SCREEN
©
MORPHOLOGY FLAG LIST
36
LLTTPP HEMATOLOGY REVIEW CRITERION EDITOR SCREENHEMATOLOGY REVIEW CRITERION EDITOR SCREEN
©
SYSTEM OPERATIONAL ALERTS
37
LLTTPP HEMATOLOGY HEMATOLOGY REVIEW CRITERION EDITOR SCREENREVIEW CRITERION EDITOR SCREEN
©
OPERATORS
38
LLTTPP HEMATOLOGY REVIEW CRITERION EDITOR SCREENHEMATOLOGY REVIEW CRITERION EDITOR SCREEN
©
RELATIONAL OPERATORS
39
LLTTPP HEMATOLOGY REVIEW CRITERION EDITOR SCREENHEMATOLOGY REVIEW CRITERION EDITOR SCREEN
©
LIST OF ACTIONS
40
LLTTPP HEMATOLOGY REVIEW CRITERION EDITOR SCREENHEMATOLOGY REVIEW CRITERION EDITOR SCREEN
©
EVALUATOR Features Follow-up procedure worklists are created based
on your criteria Special follow-up options include automatic
replacement of instrument parameter values by values obtained on the instrument by other means; e.g. WIC/WOC
Audit trail maintenance: Database archival of up to 500,000 specimen records Every state of every record is stored in a database All changes made to results are recorded/audit trailed
– WHO, WHEN and WHY any change was made– WHAT Method used to make the change
Final disposition state for each specimen record is recorded
41
LLTTPP HEMATOLOGYHEMATOLOGY™™
EVALUATOR MODULEEVALUATOR MODULE
©
LLTTPP HEMATOLOGY HEMATOLOGY EVALUATOR MODULE SCREENEVALUATOR MODULE SCREEN
©
Functions Provides for all operations: label printing, data
entry/modification, Supervisory review/approval, tracks current status and audit trail of results, and provides for archive and retrieval
Features Auto-verifies analyzer results Issues follow-up worklists along with procedures Provides data entry screens for necessary results
changesOn-screen diffpad or microscopic observation entry
Determines final disposition Stores every state of every specimen record in a
database
43
PROCESSOR MODULEPROCESSOR MODULE
LLTTPP HEMATOLOGYHEMATOLOGY™™
©
PROCESSOR Features Open architecture supports any combination of:
Analyzer manufacturers/models Body fluid types Species
Analyzes specimen results on-line in real-time, using your verification criteria. Special verification options include:
– Activation/de-activation of individual rules within a set– Advanced delta-check techniques – Color coding for: Rerun, Diff needed, Spun Hct– Tech ID, data entry, results and workstation tracked
44
PROCESSOR MODULEPROCESSOR MODULE
LLTTPP HEMATOLOGYHEMATOLOGY™™
©
LLTTPP HEMATOLOGY HEMATOLOGY PROCESSOR SCREENPROCESSOR SCREEN
©
LLTTPP HEMATOLOGY HEMATOLOGY PROCESSOR SCREENPROCESSOR SCREEN
©
MORE SPECIMENINFORMATION
47
LLTTPP HEMATOLOGY HEMATOLOGY REVIEW SPECIMEN RECORD DATA SCREENREVIEW SPECIMEN RECORD DATA SCREEN
©
REVIEW RATE BY ACTION
48
LLTTPP HEMATOLOGY HEMATOLOGY REVIEW SPECIMEN RECORD DATA SCREENREVIEW SPECIMEN RECORD DATA SCREEN
©
LLTTPP HEMATOLOGY HEMATOLOGY PROCESSOR SCREENPROCESSOR SCREEN
©
50
ENDSHIFT MODULEENDSHIFT MODULE
LLTTPP HEMATOLOGYHEMATOLOGY™™
FunctionsCloses Instrument Manager and
Evaluator at predetermined times during the day
Creates shift reports that include Overall workshift output Technologist productivity Analyzer outputs by table and graphical
display Review rules analysis
Saves reports on system server and emails reports to designated addresses
©
51
ENDSHIFT MODULEENDSHIFT MODULE
LLTTPP HEMATOLOGYHEMATOLOGY™™
Features Endshift times can vary by day and shift Multiple Endshifts per day can be programmed Report contents and recipients are user definable The Endshift process is entirely automatic
Stops Instrument Manager and Evaluator automatically
Restarts Instrument Manager and Evaluator automatically when Endshift process is completed
Endshift will not occur if LLTTPP detects that specimens are still being processed
Number of Endshift retries and retry intervals are user definable
©
LLTTPP ENDSHIFT REPORTED RESULTSENDSHIFT REPORTED RESULTS
YOUR LAB ADDRESS, ETC
©
LLTTPP ENDSHIFT PENDING RESULTSENDSHIFT PENDING RESULTS
YOUR LAB ADDRESS, ETC
©
LLTTPP ENDSHIFT CUMULATIVE INSTRUMENT REPORTENDSHIFT CUMULATIVE INSTRUMENT REPORT
YOUR LAB ADDRESS, ETC
©
LLTTPP ENDSHIFT INSTRUMENT MANAGER REPORTENDSHIFT INSTRUMENT MANAGER REPORT
YOUR LAB ADDRESS, ETC
©
LLTTPP ENDSHIFT INSTRUMENT MANAGER REPORTENDSHIFT INSTRUMENT MANAGER REPORT
YOUR LAB ADDRESS, ETC
©
LLTTPP ENDSHIFT INSTRUMENT MANAGER REPORTENDSHIFT INSTRUMENT MANAGER REPORT
YOUR LAB ADDRESS, ETC
©
LLTTPP ENDSHIFT INSTRUMENT MANAGER REPORTENDSHIFT INSTRUMENT MANAGER REPORT
YOUR LAB ADDRESS, ETC
©
WHAT LLTTPP OPTIMIZER OPTIMIZER DOES LLTTPP OPTIMIZEROPTIMIZER/HEMATOLOGY/HEMATOLOGYTM TM is
software that helps you optimize specimen results throughput in the laboratory It uses your results-verification criteria to
measure the overall specimen-result review rate in the laboratory
It determines the frequency of follow-ups based on each criterion, and the frequency of each follow-up procedure such as analyzer reruns or manual differentials
It allows you to adjust the criteria and re-analyze the results so that you can optimize your criteria and improve throughput
59
LLTTPP OPTIMIZER/OPTIMIZER/HEMATOLOGYHEMATOLOGY™™
©
WHAT LLTTPP OPTIMIZER OPTIMIZER DOESFeatures
LLTTPP OPTIMIZEROPTIMIZER/HEMATOLOGY/HEMATOLOGYTM TM
provides review rates: For all specimens combined Based on individual review criterion Based on instrument, for multiple-instrument
systems Based on instrument model, for labs using
more than one analyzer model (open architecture)
Based on body fluid type, for labs running whole blood samples and other body fluids
Based on species, for veterinary labs
60
LLTTPP OPTIMIZEROPTIMIZER/HEMATOLOGY/HEMATOLOGY™™
©
Functions Queries either the live or archival database for
performance parameters Productivity summary by analyzer or by operator # of specimens analyzed over time interval per species,
analyzer, tech, body fluid type, etc. # of specimens work-listed per rule, per species, per
analyzer, per body fluid type # of follow-up actions per rule, per species, per analyzer,
per body fluid type
Features Analysis of archived results based on rules applied
live Analysis of archived results using modified review
rules61
LLTTPP OPTIMIZER OPTIMIZER QUERY MODULEQUERY MODULE
LLTTPP OPTIMIZEROPTIMIZER/HEMATOLOGY/HEMATOLOGY™™
©
LLTTPP OPTIMIZER OPTIMIZER QUERY CATEGORIES SCREENQUERY CATEGORIES SCREEN
©
LLTTPP OPTIMIZER OPTIMIZER QUERY RESULTS SCREENQUERY RESULTS SCREEN
©
HOW LLTTPP REDUCES OPERATING COSTS
Redeployment of skilled results-review staff
Eliminates erroneous specimen record handling decisions
Optimizes review criteria/follow-up processes
Provides audit trail
64
LLTTPP HEMATOLOGYHEMATOLOGY™™
©
LLTTPP BALBAL/HEMATOLOGY/HEMATOLOGY™™
Hematology Products
LLTTPP HEMATOLOGYHEMATOLOGY™™
65
LLTTPP QCQC SENTINELSENTINEL/HEMATOLOGY/HEMATOLOGY™™
LLTTPP MOUSE MOUSE BALBAL™™ LLTTPP RAT RAT BALBAL™™ LLTTPP GUINEA PIG GUINEA PIG BALBAL™™
LLTTPP MONKEY MONKEY BALBAL™™
©
WHAT LLTTPP BAL/HEMATOLOGY DOES LLTTPP BAL/HEMATOLOGY is software that
automates BAL fluid specimen analyses on ADVIA 120/2120 No sample preparation Reduces sample analysis time to approximately 1
minute/sample Reports results in XL spreadsheet format
WBC #,%Neuts #,%Eos #,% Mononuclear cells
Does NOT affect or alter ADVIA 120/2120 software
66
LLTTPP BALBAL/HEMATOLOGY/HEMATOLOGY™™
©
WHAT LLTTPP BAL/HEMATOLOGY DOES Product Features
WBC count @20 cells/µL Differential @50 cells/µL No RBC interference in WBC analysis Species supported
Mouse allergic model and smoke inhalation modelRat allergic model and smoke inhalation modelCynomolgus monkey allergic modelGuinea pig allergic model
Does NOT affect or alter ADVIA 120/2120 software
67
LLTTPP BALBAL/HEMATOLOGY/HEMATOLOGY™™
©
Mouse
Whole Blood
Mouse BAL
Eos Model
Whole Blood Archetype
Mouse BAL
Eos Model
BAL Archetype
WBC
(/uL)
%N %E %L %MNC
MAN 103 7.0 55.7 6.7 30.7
WB ARCH
180 12.6 38.7 32.8
15.9
BAL
ARCH100 0.0 50.0 10.
040.0
Comparative Results
Eos
Lymphs
MNCLipid
MN
PMN
68
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
LLTTPP MOUSE MOUSE BALBAL™™
©
Mouse BAL
EOS + Neuts Model
Whole Blood Archetype
Mouse BAL
Eos + Neuts Model
BAL Archetype
WBC
(/uL)
%N %E %L %MNC
MAN No Manual
31 8 3 58
WB ARCH
NA 16.2 13.8 25.2 43.9
BAL
ARCHNA 37.8 8.9 13.3 40.0
Comparative Results
69
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
Mouse
LLTTPP MOUSE MOUSE BALBAL™™
©
Mouse BAL
Smoke Inhalation
Negative Control
Whole Blood Archetype
Mouse BAL
Smoke Inhalation
Negative Control
BAL Archetype
WBC
(/uL)
%N %MNC
MAN 12.5 0.5 99.5
WB
ARCH
70 28.3 47.2
BAL ARCH
20 0 100
Comparative Results
70
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
Mouse
LLTTPP MOUSE MOUSE BALBAL™™
©
Mouse BAL
Smoke Inhalation
Positive CTRL
Whole Blood Archetype
Mouse BAL
Smoke Inhalation
Positive CTRL
BAL Archetype
WBC
(/uL)
%N %MNC
MAN 142.5 43.5 56.5
WB
ARCH
460 50.9 32.0
BAL
ARCH
120 50 50
Comparative Results
Debris
71
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
Mouse
LLTTPP MOUSE MOUSE BALBAL™™
©
Mouse BAL
Smoke Inhalation
Drug-Treated
Whole Blood Archetype
Mouse BAL
Smoke Inhalation
Drug-Treated
BAL Archetype
WBC
(/uL)
%N %MNC
MAN 70 28 72
WB ARCH
190 28.5 47.8
BAL
ARCH
58 31 69
Comparative Results
72
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
Mouse
LLTTPP MOUSE MOUSE BALBAL™™
©
Rat
Whole Blood
BAL
Allergic Model
Negative Control
Whole Blood Archetype
BAL
Allergic Model
Negative Control
BAL Archetype
WBC
(/uL)
%N %E %MNC
MAN 133 8 5 87
WB
ARCH
140 36.6 3.6 59.9
BAL ARCH
130 13.8 1.5 84.6
Comparative Results
MN
PMN
MNC
LymphsNeuts
Eos
Debris
73
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
LLTTPP RAT RAT BALBAL™™
©
Rat
Rat BAL
Allergic Model
Positive Control
Whole Blood Archetype
Rat BAL
Allergic Model
Positive Control
BAL Archetype
WBC
(/uL)
%N %E %MNC
MAN 450 34 29 37
WB
ARCH
460 40.7 26.9 30.8
BAL ARCH
421 45.6 21.1 33.3
Comparative Results
74
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
LLTTPP RAT RAT BALBAL™™
©
Rat BAL
Allergic Model
Drug-Treated
Whole Blood Archetype
Rat BAL
Allergic Model
Drug-Treated
BAL Archetype
WBC
(/uL)
%N %E %MNC
MAN 623 25 65 10
WB
ARCH
620 14.3 70.0 15.5
BAL ARCH
576 24.8 59.5 15.6
Comparative Results
75
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
Rat
LLTTPP RAT RAT BALBAL™™
©
CynomolgusMonkeyWhole Blood
Cyno Monkey BAL
Allergic Model
Negative Control
Whole Blood Archetype
Cyno Monkey
Allergic Model
Negative Control
BAL Archetype
WBC
(/uL)
%N %E %MNC
MAN 100 1 1 98
WB ARCH
190 39.7 1.3 59
BAL ARCH
92 7.5 6 86.5
Comparative Results
MN PMN
Debris
MNC
Lymphs
Neuts
Eos
76
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
LLTTPP MONKEY MONKEY BALBAL™™
©
Cyno Monkey BAL
Allergic Model
Positive Control
Whole Blood Archetype
Cyno Monkey BAL
Allergic Model
Positive Control
BAL Archetype
WBC
(/uL)
%N %E %MNC
MAN 346 7.3 49.0 43.7
WB
ARCH
440 52.0 12.0 36.0
BAL ARCH
342 4.5 39.7 55.7
Comparative Results
77
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
CynomolgusMonkey
LLTTPP MONKEY MONKEY BALBAL™™
©
Guinea Pig
Whole Blood
Guinea Pig BAL Allergic Model
Positive Control
Whole Blood Archetype
Guinea Pig BAL Allergic Model
Positive Control
BAL Archetype
WBC
(/uL)
%Neut %Eos %MNC
Man 2900 36.5 45.5 18.0
WB
Arch
2950 46.4 29.4 24.2
BAL Arch
2950 31.0 45.5 23.5
Comparative Results
Debris
Eos
NMC
Neuts
78Debris
LLTTPP BALBAL/HEMATOLO/HEMATOLO
GYGY™™
LLTTPP GUINEA PIG GUINEA PIG BALBAL™™
©
HOW LLTTPP REDUCES OPERATING COSTS
Automate time intensive manual process Provide standardized objective criteria Reduces specimen analysis time Allows redeployment of skilled staff
79
LLTTPP BALBAL/HEMATOLOGY/HEMATOLOGY™™
©
LLTTPP ACHIEVERACHIEVER/COAGULATION/COAGULATION™™
LLTTPP OPTIMIZEROPTIMIZER/COAGULATION/COAGULATION™™
Coagulation Products
LLTTPP COAGULATIONCOAGULATION™™
80
LLTTPP QCQC SENTINELSENTINEL/COAGULATION/COAGULATION™™
©
WHAT LLTTPP ACHIEVERACHIEVER DOES LLTTPP ACHIEVERACHIEVER /COAGULATION /COAGULATION is a
complete results processing system. Auto-verifies coagulation analyzer results Issues follow-up worklists along with procedures Provides data entry screens for necessary results
changes Determines final disposition Transmits results to the host computer system for
release Stores every state of every specimen record in a
database
81
LLTTPP ACHIEVERACHIEVER/COAGULATION/COAGULATION™™
©
WHAT LLTTPP ACHIEVERACHIEVER DOESFeatures
Open architecture supports any combination of:Analyzer manufacturers/models Body fluid types Species
Analyzes specimen results on-line in real-time, using your verification criteria. Special verification options include:
– Activation/de-activation of individual rules within a set– Advanced delta-check techniques – Rerun-only criteria
82
LLTTPP ACHIEVERACHIEVER/COAGULATION/COAGULATION™™
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WHAT LLTTPP ACHIEVERACHIEVER DOES Features
Follow-up procedure worklists are created based on your criteria
Audit trail maintenance: Database archival of up to 500,000 specimen records Every state of every record is stored in a database All changes made to results are recorded/audit trailed
– WHO, WHEN and WHY any change was made
– WHAT Method used to make the change
Final disposition state for each specimen record is recorded
83
LLTTPP ACHIEVERACHIEVER/COAGULATION/COAGULATION™™
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WHAT LLTTPP OPTIMIZEROPTIMIZER DOES LLTTPP OPTIMIZEROPTIMIZER /COAGULATION /COAGULATION ™ is
software that helps you optimize specimen results throughput in the laboratory It uses your coagulation results-verification
criteria to measure the overall specimen-result review rate in the laboratory
It determines the frequency of follow-ups based on each criterion, and the frequency of each follow-up procedure such as analyzer reruns or prolonged clotting times
It allows you to adjust the criteria and re-analyze the results so that you can optimize your criteria and improve throughput
84
LLTTPP OPTIMIZER/OPTIMIZER/COAGULATIONCOAGULATION™™
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WHAT LLTTPP OPTIMIZEROPTIMIZER DOESFeatures
LTP OPTIMIZEROPTIMIZER /COAGULATION /COAGULATION ™ provides review rates:
For all specimens combined Based on individual review criterion Based on instrument, for multiple-instrument
systems Based on instrument model, for labs using
more than one analyzer model (open architecture)
Based on body fluid type, for labs running whole blood samples and other body fluids
Based on species, for veterinary labs
85
LLTTPP OPTIMIZEROPTIMIZER/COAGULATION/COAGULATION™™
©
LLTTPP ACHIEVERACHIEVER/CHEMISTRY/CHEMISTRY™™
LLTTPP OPTIMIZEROPTIMIZER/CHEMISTRY/CHEMISTRY™™
Chemistry Products
LLTTPP CHEMISTRYCHEMISTRY™™
86
LLTTPP QCQC SENTINELSENTINEL/CHEMISTRY/CHEMISTRY™™
©
WHAT LLTTPP ACHIEVERACHIEVER DOES LLTTPP ACHIEVERACHIEVER/CHEMISTRY /CHEMISTRY is a complete
results processing system. Auto-verifies chemistry analyzer results Issues follow-up worklists along with procedures Provides data entry screens for necessary results
changes Determines final disposition Transmits results to the host computer system for
release Stores every state of every specimen record in a
database
87
LLTTPP ACHIEVERACHIEVER/CHEMISTRY/CHEMISTRY™™
©
WHAT LLTTPP ACHIEVERACHIEVER DOESFeatures
Open architecture supports any combination of:Analyzer manufacturers/models Body fluid types Species
Analyzes specimen results on-line in real-time, using your verification criteria. Special verification options include:
– Activation/de-activation of individual rules within a set– Advanced delta-check techniques – Rerun-only criteria
88
LLTTPP ACHIEVERACHIEVER/CHEMISTRY/CHEMISTRY™™
©
WHAT LLTTPP ACHIEVERACHIEVER DOES Features
Follow-up procedure worklists are created based on your criteria
Audit trail maintenance: Database archival of up to 500,000 specimen records Every state of every record is stored in a database All changes made to results are recorded/audit trailed
– WHO, WHEN and WHY any change was made
– WHAT Method used to make the change
Final disposition state for each specimen record is recorded
89
LLTTPP ACHIEVERACHIEVER/CHEMISTRY/CHEMISTRY™™
©
WHAT LLTTPP OPTIMIZEROPTIMIZER DOES LLTTPP OPTIMIZEROPTIMIZER/CHEMISTRY /CHEMISTRY ™ is software
that helps you optimize specimen results throughput in the laboratory It uses your chemistry results-verification criteria
to measure the overall specimen-result review rate in the laboratory
It determines the frequency of follow-ups based on each criterion, and the frequency of each follow-up procedure such as analyzer reruns, below detection limit or dilutions needed.
It allows you to adjust the criteria and re-analyze the results so that you can optimize your criteria and improve throughput
90
LLTTPP OPTIMIZER/OPTIMIZER/CHEMISTRYCHEMISTRY™™
©
WHAT LLTTPP OPTIMIZER OPTIMIZER DOESFeatures
LLTTPP OPTIMIZER OPTIMIZER /CHEMISTRY /CHEMISTRY ™ provides review rates:
For all specimens and parameters combined Based on your individual review criterion Based on instrument, for multiple-instrument
systems Based on instrument model, for labs using
more than one analyzer model (open architecture)
Based on body fluid type, for labs running whole blood samples and other body fluids
Based on species, for veterinary labs
91
LLTTPP OPTIMIZEROPTIMIZER/CHEMISTRY/CHEMISTRY™™
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LLTTPP ACHIEVERACHIEVER/URINALYSIS/URINALYSIS™™
LLTTPP OPTIMIZEROPTIMIZER/URINALYSIS/URINALYSIS™™
Urinalysis Products
LLTTPP URINALYSISURINALYSIS™™
92
LLTTPP QCQC SENTINELSENTINEL/URINALYSIS/URINALYSIS™™
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WHAT LLTTPP ACHIEVERACHIEVER DOES LLTTPP ACHIEVERACHIEVER/URINALYSIS /URINALYSIS is a complete
results processing system. Auto-verifies urinalysis analyzer results Issues follow-up worklists along with procedures Provides data entry screens for necessary results
changesOn-screen microscopic observation data entry pad
Determines final disposition Transmits results to the host computer system for
release Stores every state of every specimen record in a
database93
LLTTPP ACHIEVERACHIEVER/URINALYSIS/URINALYSIS™™
©
WHAT LLTTPP ACHIEVERACHIEVER DOESFeatures:
Open architecture supports any combination of:Analyzer manufacturers/models Body fluid types Species
Analyzes specimen results on-line in real-time, using your verification criteria. Special verification options include:
– Activation/de-activation of individual rules within a set– Advanced delta-check techniques – Rerun-only criteria
94
LLTTPP ACHIEVERACHIEVER/URINALYSIS/URINALYSIS™™
©
WHAT LLTTPP ACHIEVERACHIEVER DOES Features
Follow-up procedure worklists are created based on your criteria
Audit trail maintenance: Database archival of up to 500,000 specimen records Every state of every record is stored in a database All changes made to results are recorded/audit trailed
– WHO, WHEN and WHY any change was made
– WHAT Method used to make the change
Final disposition state for each specimen record is recorded
95
LLTTPP ACHIEVERACHIEVER/URINALYSIS/URINALYSIS™™
©
WHAT LLTTPP OPTIMIZEROPTIMIZER DOES LLTTP P OPTIMIZER/OPTIMIZER/URINALYSISURINALYSIS™ ™ is software
that helps you optimize specimen results throughput in the laboratory It uses your urinalysis results-verification criteria
to measure the overall specimen-result review rate in the laboratory
It determines the frequency of follow-ups based on each criterion, and the frequency of each follow-up procedure such as analyzer reruns or microscopic element types (eg. crystals)
It allows you to adjust the criteria and re-analyze the results so that you can optimize your criteria and improve throughput
96
LLTTPP OPTIMIZER/OPTIMIZER/URINALYSISURINALYSIS™™
©
WHAT LLTTP P OPTIMIZEROPTIMIZER DOES Features
provides review rates: For all specimens combined Based on your individual review criterion Based on instrument, for multiple-instrument
systems Based on instrument model, for labs using
more than one analyzer model (open architecture)
Based on body fluid type, for labs running whole blood samples and other body fluids
Based on species, for veterinary labs
97
LLTTPP OPTIMIZEROPTIMIZER/URINALYSIS/URINALYSIS™™
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LabLabThroughThroughPutPut ™™ Products Products
98
LLTTPP HEMATOLOGYHEMATOLOGY™™
LLTTPP COAGULATIONCOAGULATION™™ LLTTPP CHEMISTRYCHEMISTRY™™ LLTTPP URINALYSISURINALYSIS™™
LLTTPP QCQC SENTINELSENTINEL™™
Quality Control Module
QC SENTINELQC SENTINEL MODULEMODULE
IS PRESENTLY UNDER IS PRESENTLY UNDER DEVELOPMENTDEVELOPMENT
©
99
WITHOUT LLTTPP MIDDLEWAREMIDDLEWARE
General LIS ConfigurationGeneral LIS Configuration
An LIS LIS has multiple connections multiple connections and interfaces, in multiple categoriesAnalyzer – LIS
A different interface for each analyzer brand
Numerous Data Entry WorkstationsPrinters
©
MainServer
BackupServer
SLIDES SLIDES SLIDES SLIDES
A4
BC PRT
PRT
SLIDES DIFFS DIFFS DIFFSDIFFS DIFFS DIFFS DIFFS DIFFS
A1
A2
A3
A5
A6
CD4
CD3
A7
CD2
A8
CD1
A14
A9
A10
A11
A12
A13
SupWS3
SupWS2
SupWS1
ANTRIM
External Storage
SLIDES = slide-making workstations
DIFFS = Diff-reader workstations
PRT = Printer
BC PRT = Barcode printer
SUP WS1-3 = Supervisor workstations
InstMgr12 = Instrument Manager workstation
External Storage = Terabyte drive
A1-A14 = ADVIA 120 Analyzers
CD1-CD4 = CellDyn 3500 Analyzers
Notes:
1. Server-to-Server connection by dedicated NICs.
2. InstMgr-to-Analyzer and InstMgr-to-ANTRIM connections via serial ports.
3. Analyzer-to-ANTRIM failsafe direct serial port connections not shown.
4. Circled numbers are hub connection #s
General LIS Configuration
1-6 8-15
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101
WITH WITH LLTTPP MIDDLEWAREMIDDLEWARE
LLTTPP MIDDLEWAREMIDDLEWARE™ ™ SYSTEM SYSTEM ConfigurationConfiguration
The LIS LIS has only a single connection single connection to LLTTPP Middleware Middleware
LLTTPP Middleware Middleware is responsible for interfacing to the various categories of devices
LLTTPP Middleware Middleware unburdens the LIS LIS of interfacing with multiple laboratory devices, each with its own interface specification
Bidirectional LLTTPP Middleware – Middleware – LIS LIS interfaces follow standards such as ASTM1381/1395 or HL7
©
MainServer
BackupServer
SLIDES SLIDES SLIDES SLIDES
A4
BC PRT
PRT
SLIDES DIFFS DIFFS DIFFSDIFFS DIFFS DIFFS DIFFS DIFFS
A1
A2
A3
A5
A6
CD4
CD3
A7
CD2
A8
CD1
A14
A9
A10
A11
A12
A13
LLTTPPInstMgr
SupWS3
SupWS2
SupWS1
ANTRIM
External Storage
SLIDES = slide-making workstations
DIFFS = Diff-reader workstations
PRT = Printer
BC PRT = Barcode printer
SUP WS1-3 = Supervisor workstations
InstMgr12 = Instrument Manager workstation
External Storage = Terabyte drive
A1-A14 = ADVIA 120 Analyzers
CD1-CD4 = CellDyn 3500 Analyzers
Notes:
1. Server-to-Server connection by dedicated NICs.
2. InstMgr-to-Analyzer and InstMgr-to-ANTRIM connections via serial ports.
3. Analyzer-to-ANTRIM failsafe direct serial port connections not shown.
4. Circled numbers are hub connection #s
DSL
Hub
1-67
8-15
16-1920
21 22
LLTTPP Middleware System Configuration
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103
LLTTPP System Backup System Backup
LLTTPP MIDDLEWAREMIDDLEWARE™ ™ SYSTEMSYSTEM
LLTTPP MIDDLEWAREMIDDLEWARE automatically copies the system environment, including applications and DB, to External Media daily
LLTTPP MIDDLEWARE MIDDLEWARE also continually replicates the environment to a Backup Server
The LLTTPP Backup Server automatically takes over if the Main Server fails
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104
LLTTPP MIDDLEWAREMIDDLEWARE™ ™ SYSTEMSYSTEM
LLTTPP TECHNICAL SUPPORT Available whenever the laboratory is in
operation Lab personnel can call a telephone number
and speak directly with support staff Support staff have remote access to the
middleware system which enables them to quickly diagnose a problem and to make any necessary changes
LLTTPP System Technical Support System Technical Support
©
Thank YouThank You
for your attention.for your attention.
105
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