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6×4
1. ③ !
!
! ③③
A.
B.
C.
D.
2. The structure of HClO4•H2O was proved to be H3O+ClO4-. The following statement that can
BEST support this structure of HClO4•H2O is:
A HClO4•H2O is a strong acid
B HClO4•H2O is a strong oxidant
C HClO4•H2O decomposes at high temperature
D Four identical bonds are present in HClO4•H2O
3. ③
!
2
A B C
4.
! −OBs −OC6H4Br
A. B. C. D.
!
3
5. Bullvalene Cope
13C
etc
A. 1 B. 6 C. 12 D. 45
6. Calicheamicin DNA “
Calicheamicin
~
A. B. C. D.
16
1. ③ DNA
2. EDTA EDTA
EDTA ③
EDTA EDTA
3. Nature
III 2b CO2 !
!
4
4.
DNA
DNA T U
60
1. 6,8- -1,3- DHP RV 1 1
pH ) pH
RV DHP
!!
!!
!!
!!
!!
!
5
1.1
1.2 pH
2. 》
2.1 C-O (
(
2.2
2.3 -OCH3 -NO2
3. Ingenol SI-15 Hecker Euphorbia ingens
in, out-[4.4.1]
HIV FDA
ingenol 2- -2-
ingenol “ 2013
Scripps P. S. Baran (+)- (+)-ingenol
14
3.1 ingenol in, out
3.2 SI-10 SI-11
BF3
3.3 1999 ingenol
vinylogous retro-pinacol rearrangement
!
6
4.
!
③
1,2-
A 4.1 A
2
4.1
4.2 A
4.3 A
4.4 4.2
4.1 A 4.2 A
5. DHFR Glu17 Ile115
4- -L- 1 L-(7- -4- )
2
!
7
5.1 1 2
5.2 DHFR
5.1 DHFR
mRNA ! ; DHFR 。
DHFR
1 2 Glu17 Ile115 DHFR 6
5.2 5.3 DHFR
0.5 µM pH = 8.0
Glu17
1 2
1 DHFR I DHFR1
2 DHFR II DHFR2
DHFR3 DHFR4 DHFR
Ile115
!
8
5.2 I DHFR1 280 nm II DHFR I 280 nm
III IV DHFR 4 340 nm 280 nm
5.3 I DHFR3 II DHFR2 III DHFR II 280 nm
5.3 5.5
5.3 1 2
5.4 DHFR I DHFR II 280 nm DHFR
5.5 , 5.2 II 5.3 III 4
I
II
III
IV
I
II
III
!
9
DHFR I DHFR II
5.6 TMP DHFR DHFR
DHFR II
6.4 TMP DHFR II
I II III IV TMP 0 2 4 6 µM
280 nm 5.3 5.5
TMP DHFR II
DHFR
I
II III
IV